The Impact of Genetic Polymorphisms on Anterior Cruciate Ligament Injuries in Athletes: A Meta-Analytical Approach
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Collection and Selection of Relevant Studies
2.2. Data Extraction and Evaluation
2.3. Study Quality Assessment
2.4. Statistical Analysis
3. Results
3.1. The COL1A1 (rs1107946) Allele and Genotype Distribution (ACL vs. Control)
3.2. The COL3A1 (rs1800255) Allele and Genotype Distribution (ACL vs. Control)
3.3. The COL5A1 (rs12722) Allele and Genotype Distribution (ACL vs. Control)
3.4. The COL12A1 (rs970547) Allele and Genotype Distribution (ACL vs. Control)
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Race | Name Genes (rs Number) | Total Athletes | Total Controls | Newcastle–Ottawa Scale | |||
---|---|---|---|---|---|---|---|---|
Sel | Com | Exp | Total | |||||
Mirghaderi et al. (2022) [22] | C | COL1A1 (rs1107946) | 200 | 200 | 3 | 2 | 3 | 8 |
Gibbon et al. (2020) [6] | A | COL1A1 (rs1107946) | 197 | 225 | 3 | 1 | 3 | 7 |
Ficek et al. (2013) [7] | E | COL1A1 (rs1107946) | 91 | 143 | 3 | 1 | 3 | 7 |
Perini et al. (2022) [21] | M | COL1A1 (rs1107946) | 146 | 192 | 3 | 2 | 3 | 8 |
Stepien-Slodkowska et al. (2017) [9] | E | COL1A1 (rs1107946) | 138 | 183 | 3 | 1 | 2 | 6 |
Sivertsen et al. (2018) [11] | E | COL1A1 (rs1107946) | 119 | 732 | 2 | 2 | 2 | 6 |
O’Connell et al. (2015) [15] | C | COL3A1 (rs1800255) | 311 | 356 | 3 | 2 | 3 | 8 |
Sivertsen et al. (2018) [11] | E | COL3A1 (rs1800255) | 119 | 732 | 2 | 2 | 2 | 6 |
Stepien-Slodkowska et al. (2015) [8] | E | COL3A1 (rs1800255) | 138 | 183 | 3 | 1 | 2 | 6 |
Alvarez-Romero et al. (2023) [22] | M | COL5A1 (rs12722) | 582 | 308 | 2 | 2 | 2 | 6 |
Lulińska-Kuklik et al. (2018) [16] | E | COL5A1 (rs12722) | 134 | 211 | 3 | 2 | 3 | 8 |
O’Connell et al. (2015) [15] | C | COL5A1 (rs12722) | 311 | 356 | 3 | 2 | 3 | 8 |
Sivertsen et al. (2018) [11] | E | COL5A1 (rs12722) | 119 | 732 | 2 | 2 | 2 | 6 |
Posthumus et al. (2009) [14] | A | COL5A1 (rs12722) | 129 | 216 | 3 | 2 | 3 | 8 |
Stepien-Slodkowska et al. (2015) [8] | E | COL5A1 (rs12722) | 138 | 183 | 3 | 1 | 2 | 6 |
Ficek et al. (2014) [23] | E | COL12A1 (rs970547) | 91 | 143 | 3 | 1 | 3 | 7 |
O’Connell et al. (2015) [15] | C | COL12A1 (rs970547) | 311 | 356 | 3 | 2 | 3 | 8 |
Sivertsen et al. (2018) [11] | E | COL12A1 (rs970547) | 119 | 732 | 2 | 2 | 2 | 6 |
Posthumus et al. (2009) [14] | A | COL12A1 (rs970547) | 129 | 216 | 3 | 2 | 3 | 8 |
Meta Analysis | Heterogeneity | Publ. Bias | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gene | n | MA | OR | Lower CI | Upper CI | p | I2 | Q (df) | p-Value of Q | Egger’s | |
Allele-based OR (95%Cl) | COL1A1 (rs1107946) | 6 | G | −0.27 | −0.42 | −0.12 | 0.001 *F | 87.22% | 39.135 | 0.001 | 0.094 |
COL3A1 (rs1800255) | 3 | G | 0.03 | −0.16 | 0.22 | 0.756 R | 14.36% | 2.018 | 0.365 | 0.245 | |
COL5A1 (rs12722) | 6 | T | 0.11 | −0.01 | 0.23 | 0.081 R | 22.59% | 5.270 | 0.384 | 0.050 | |
COL12A1 (rs970547) | 4 | A | 0.18 | 0.01 | 0.36 | 0.041 *R | 0% | 1.594 | 0.661 | 0.321 | |
DM-based OR (95%Cl) | COL1A1 (rs1107946) | 6 | G | −0.20 | −0.38 | −0.01 | 0.034 *F | 87.34% | 39.497 | 0.001 | 0.001 |
COL3A1 (rs1800255) | 3 | G | 0.11 | −0.15 | 0.37 | 0.402 R | 27.61% | 2.726 | 0.256 | 0.951 | |
COL5A1 (rs12722) | 6 | T | 0.14 | −0.02 | 0.31 | 0.088 R | 4.84% | 3.733 | 0.589 | 0.307 | |
COL12A1 (rs970547) | 4 | A | 0.19 | −0.01 | 0.39 | 0.062 R | 0% | 1.768 | 0.622 | 0.707 | |
RM-based OR (95%Cl) | COL1A1 (rs1107946) | 6 | G | 0.69 | 0.33 | 1.05 | 0.001 *F | 87.66% | 40.512 | 0.001 | 0.023 |
COL3A (rs1800255) | 3 | G | 0.18 | −0.26 | 0.62 | 0.417 F | 72.51% | 7.275 | 0.026 | 0.012 | |
COL5A1 (rs12722) | 6 | T | −0.24 | −0.48 | 0.01 | 0.059 R | 34.88% | 6.901 | 0.228 | 0.302 | |
COL12A1 (rs970547) | 4 | A | 0.19 | −0.28 | 0.65 | 0.432 R | 0% | 1.881 | 0.598 | 0.522 |
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Bulbul, A.; Ari, E.; Apaydin, N.; Ipekoglu, G. The Impact of Genetic Polymorphisms on Anterior Cruciate Ligament Injuries in Athletes: A Meta-Analytical Approach. Biology 2023, 12, 1526. https://doi.org/10.3390/biology12121526
Bulbul A, Ari E, Apaydin N, Ipekoglu G. The Impact of Genetic Polymorphisms on Anterior Cruciate Ligament Injuries in Athletes: A Meta-Analytical Approach. Biology. 2023; 12(12):1526. https://doi.org/10.3390/biology12121526
Chicago/Turabian StyleBulbul, Alpay, Erdal Ari, Necdet Apaydin, and Gokhan Ipekoglu. 2023. "The Impact of Genetic Polymorphisms on Anterior Cruciate Ligament Injuries in Athletes: A Meta-Analytical Approach" Biology 12, no. 12: 1526. https://doi.org/10.3390/biology12121526