Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism
Abstract
:1. Introduction
2. ROS and Radioresistance
3. OXPHOS and Radioresistance
4. Oncometabolites and Radioresistance
5. Apoptosis and Radioresistance
6. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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OXPHOS Inhibitor | Identifier | Phase | Cancer Type | ECT Target | Ref. |
---|---|---|---|---|---|
Metformin | NCT04275713, NCT04414540, NCT04945148, NCT04387630 | II, II, II, II | Cervical cancer, head and neck squamous cell carcinoma, glioblastoma (IDH-wildtype), breast cancer | Complex I | [92] |
Phenformin | NCT03026517 | I | Melanoma | Complex I | [92] |
Arsenic Trioxide | NCT02066870, NCT03503864 | I, II | Non-small-cell lung cancer, neuroblastoma | Complex I | [93] |
Papaverine | NCT05136846, NCT03824327 | I, I | Locally advanced or unresectable non-small-cell lung cancer | Complex I | [95] |
Atovaquone | NCT04648033, NCT02628080 | I, I | Locally advanced non-small-cell lung cancer, non-small-cell lung cancer | Complex III | [96] |
Proguanil | N.A. | N.A. | Acts synergistically with atovaquone | Complex I | [97] |
Pyrvinium Pamoate | NCT05055323 | I | Resectable pancreatic ductal adenocarcinoma | Complex I | [98] |
Vitamin E | NCT01871454 | II | Non-small-cell lung cancer | Complex II | [99] |
ONC201 | NCT04055649 | II | Platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, diffuse midline gliomas | Complex I, II | [100] |
Mitoxantrone | NCT04927481, NCT03839446, NCT03258320, NCT04718402 | II, II, I, I | Breast cancer, acute myeloid leukemia, prostate cancer patients, advanced gastric carcinoma | Complex V | [101] |
Ivermectin | N.A. | N.A. | Induces the death of renal cancer cells, chronic myeloid leukemia cells, and glioblastoma cells * | Complex I | [102] |
Anonacin | N.A. | N.A. | Delays the growth of pancreatic cancer cells * | Complex I | [103] |
Trifluoperazine | N.A. | N.A. | Induces pancreatic ductal adenocarcinoma cell death in combination with bortezomib * | Mitochondrial Stress | [104] |
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Bian, C.; Zheng, Z.; Su, J.; Wang, H.; Chang, S.; Xin, Y.; Jiang, X. Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism. Antioxidants 2022, 11, 2202. https://doi.org/10.3390/antiox11112202
Bian C, Zheng Z, Su J, Wang H, Chang S, Xin Y, Jiang X. Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism. Antioxidants. 2022; 11(11):2202. https://doi.org/10.3390/antiox11112202
Chicago/Turabian StyleBian, Chenbin, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, and Xin Jiang. 2022. "Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism" Antioxidants 11, no. 11: 2202. https://doi.org/10.3390/antiox11112202