Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes
Abstract
:1. Introduction
2. The HIFs Family
3. Redox Regulation of HIFs: Role of Diabetes-Related Stimuli
4. Modulation of Redox Homeostasis by HIFs in Response to Changes in Oxygen or Energy Substrate Availability
5. Dysregulated HIF Signaling and Redox Homeostasis in Cardiovascular and Renal Complications of Diabetes: Insights from Pharmacological HIF Modifiers and Perspectives for Future Research
5.1. PHD Inhibitors
5.2. Sirtuin-1 Activators
5.2.1. Resveratrol
5.2.2. Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Iacobini, C.; Vitale, M.; Haxhi, J.; Pesce, C.; Pugliese, G.; Menini, S. Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes. Antioxidants 2022, 11, 2183. https://doi.org/10.3390/antiox11112183
Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S. Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes. Antioxidants. 2022; 11(11):2183. https://doi.org/10.3390/antiox11112183
Chicago/Turabian StyleIacobini, Carla, Martina Vitale, Jonida Haxhi, Carlo Pesce, Giuseppe Pugliese, and Stefano Menini. 2022. "Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes" Antioxidants 11, no. 11: 2183. https://doi.org/10.3390/antiox11112183