Flow Synthesis of Nature-Inspired Mitochondria-Targeted Phenolic Derivatives as Potential Neuroprotective Agents
Abstract
:1. Introduction
2. Materials and Methods
2.1. Two-Step Flow Procedure for the Synthesis of MITO Compounds SP1-7
2.2. Cell Cultures and Treatment
2.3. Cell Viability and Morphology
2.4. Cell Morphology
2.5. Statistical Analysis
3. Results and Discussion
3.1. Continuous Flow Synthesis of MITO Compounds SP1-7
3.2. Effects of the MITO Compounds SP1-7 on Neuronal Cell Viability
3.3. Biological Effects of the MITO Compounds SP1-7 on Neuronal Cells
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pecora, D.; Annunziata, F.; Pegurri, S.; Picone, P.; Pinto, A.; Nuzzo, D.; Tamborini, L. Flow Synthesis of Nature-Inspired Mitochondria-Targeted Phenolic Derivatives as Potential Neuroprotective Agents. Antioxidants 2022, 11, 2160. https://doi.org/10.3390/antiox11112160
Pecora D, Annunziata F, Pegurri S, Picone P, Pinto A, Nuzzo D, Tamborini L. Flow Synthesis of Nature-Inspired Mitochondria-Targeted Phenolic Derivatives as Potential Neuroprotective Agents. Antioxidants. 2022; 11(11):2160. https://doi.org/10.3390/antiox11112160
Chicago/Turabian StylePecora, Desirée, Francesca Annunziata, Sergio Pegurri, Pasquale Picone, Andrea Pinto, Domenico Nuzzo, and Lucia Tamborini. 2022. "Flow Synthesis of Nature-Inspired Mitochondria-Targeted Phenolic Derivatives as Potential Neuroprotective Agents" Antioxidants 11, no. 11: 2160. https://doi.org/10.3390/antiox11112160