Evaluation and Analysis of Absence of Homozygosity (AOH) Using Chromosome Analysis by Medium Coverage Whole Genome Sequencing (CMA-seq) in Prenatal Diagnosis
Round 1
Reviewer 1 Report
It is a well compiled article. I think it will contribute to the literature as a subject. There are minor typos. It is appropriate to publish them as a result of their correction.
Author Response
According to your suggestion, our manuscript has undergone extensive English revisions by AJE (http://www.aje.cn/)
Reviewer 2 Report
This is an interesting article but needs English editing
1-It would have been beneficial if you add a drawn algorithm to the study design
2-Reference 23 and 32 are incomplete, there is missing data
Author Response
According to your suggestion,
1. Our manuscript has undergone extensive English revisions by AJE (http://www.aje.cn/)
2. We draw a flow chart of development and validation of CMA-seq algorithm for AOH detection as Figure 1 in the Materials and Methods part.
3.Reference 23 and 32 are revised and complete now.
