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Cells
Volume 11
Issue 6
10.3390/cells11061030
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Article
Peer-Review Record

Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer’s Disease

Cells 2022, 11(6), 1030; https://doi.org/10.3390/cells11061030
by Magdalena Mroczek 1, Christopher Clark 2, Loïc Dayon 3,4, Gene L. Bowman 5,6,7 and Julius Popp 1,2,8,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cells 2022, 11(6), 1030; https://doi.org/10.3390/cells11061030
Submission received: 22 February 2022 / Revised: 12 March 2022 / Accepted: 14 March 2022 / Published: 18 March 2022
(This article belongs to the Special Issue Alzheimer's Disease: Molecular Mechanisms and Novel Treatment Strategies)

Round 1

Reviewer 1 Report

General comment

This is a novel study investigating CSF changes related to neuro in AD, using an unbiased proteomic approach. Although detecting biomarkers in the CSF is an invasive procedure, it identifies potential biomarkers to be investigated in blood. The study is longitudinal (42 months), with appropriate sample size (87 samples) and cognitive and neuropsychiatric assessment was done using established assessments and questionnaires.

In total 27 proteins were associated with NPS. It is interesting to note that the proteins identified are at least partly distinct from AD status and suggests separate pathological processes. The same is true for single psychiatric domains, where proteins and pathways related to AD were identified specifically for apathy and depression.

 

Specific comments

 

The manuscript overall reads very well and Figure 3 is very clear. Page 9 relating to Figure 4 is more complex and for Figure 4, it might be informative to have the proteins identified for each ROC curve included in the figure.

Author Response

We thank the Reviewer for her/his quick response.
We agree with the suggested changes regarding Figure 4 and added names of the proteins.
Additionally, to improve clarity, we added names of the proteins to the Figure 2.
We proofread the mansucript and corrected typos and small language errors.

Reviewer 2 Report

The manuscript entitled “Cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease” provided alternated profiles of CSF proteome associated with neuropsychiatric symptoms in MCI and AD. I think that the data are highly valuable for the readers of cells journal. I do not have any substantial amendments to suggest.

Author Response

We thank the Reviewer for her/his quick response.
To improve clarity of the Figures, we added names of the proteins to the Figure 2 and Figure 4.
We proofread the mansucript and corrected typos and small language errors.

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