Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Identification of Proteins
2.2. Determination of Glycosylated Haemoglobin (HbA1c), Glucose, Insulin and Inflammatory Markers
2.3. Ethics
2.4. Statistical Analysis
3. Results
Changes in Inflammatory Markers vs. the Proteome
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Baseline (mean ± SEM) | 6 Months Post-MBS (mean ± SEM) | 12 Months Post-MBS (mean ± SEM) | p Value (Baseline × 6 Months) | p Value (Baseline × 12 Months) | |
---|---|---|---|---|---|
BMI | 54.9 ± 3.26 | 41.8 ± 2.20 | 38.6 ± 1.60 | <0.0001 * | <0.0001 * |
HbA1c | 56.0 ± 4.46 | 40.0 ± 1.70 | 36.44 ± 1.01 | 0.002 * | 0.004 * |
IL6 | 6.29 ± 1.19 | 4.8 ± 0.96 | 4.57 ± 1.10 | 0.160 | 0.029 * |
TNFα | 5.98 ± 0.70 | 5.27 ± 1.20 | 4.59 ± 0.67 | 0.689 | 0.245 |
CRP | 9.07 ± 2.45 | 7.14 ± 1.71 | 5.11 ± 1.88 | 0.226 | 0.180 |
HOMA-IR | 0.56 ± 0.17 | 0.48 ± 0.19 | 0.36 ± 0.08 | 0.741 | 0.380 |
HOMA-B | 331.86 ± 83.69 | 413.85 ± 104.60 | 376.43 ± 72.88 | 0.443 | 0.734 |
Protein (Gene Symbol) | Fold Change ± SEM at 6 Months | Fold Change ± SEM at 12 Months |
---|---|---|
Heat shock protein 4 (HSPA4) | 0.7648 ± 0.10156 | N/S |
Serpin family F member 1 (SERPINF1) | 0.7906 ± 0.06724 | N/S |
Galectin 3 binding protein (LGALS3BP) | N/S | 0.7074 ± 0.08600 |
Heat shock protein 90 Beta family member 1 (HSP90B1) | N/S | 0.7858 ± 0.07666 |
Angiotensin-converting enzyme (ACE) | N/S | 0.7888 ± 0.07232 |
Epoxide hydrolase 2 (EPHX2) | N/S | 0.7587 ± 0.07564 |
Sex hormone-binding globulin (SHBG) | N/S | 6.1816 ± 1.83129 |
L1 cell adhesion molecule (L1CAM) | N/S | 1.6862 ± 0.22992 |
Alpha-1-microglobulin/Bikunin precursor (AMBP) | N/S | 1.3137 ± 0.11014 * |
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Fachim, H.A.; Iqbal, Z.; Gibson, J.M.; Baricevic-Jones, I.; Campbell, A.E.; Geary, B.; Syed, A.A.; Whetton, A.; Soran, H.; Donn, R.P.; et al. Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery. Cells 2021, 10, 2798. https://doi.org/10.3390/cells10102798
Fachim HA, Iqbal Z, Gibson JM, Baricevic-Jones I, Campbell AE, Geary B, Syed AA, Whetton A, Soran H, Donn RP, et al. Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery. Cells. 2021; 10(10):2798. https://doi.org/10.3390/cells10102798
Chicago/Turabian StyleFachim, Helene A., Zohaib Iqbal, J. Martin Gibson, Ivona Baricevic-Jones, Amy E. Campbell, Bethany Geary, Akheel A. Syed, Antony Whetton, Handrean Soran, Rachelle P. Donn, and et al. 2021. "Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery" Cells 10, no. 10: 2798. https://doi.org/10.3390/cells10102798