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Review

The Roles of MADS-Box Genes from Root Growth to Maturity in Arabidopsis and Rice

by
Liaqat Shah
1,2,
Amir Sohail
1,
Rafiq Ahmad
3,
Shihua Cheng
1,
Liyong Cao
1,4,* and
Weixun Wu
1,*
1
China National Center for Rice Improvement, China National Rice Research Institute, Hangzhou 310006, China
2
Department of Agriculture, Mir Chakar Khan Rind University, Sibi 82000, Pakistan
3
Department of Botany, Mir Chakar Khan Rind University, Sibi 82000, Pakistan
4
Northern Center of China National Rice Research Institute, Hangzhou 310006, China
*
Authors to whom correspondence should be addressed.
Agronomy 2022, 12(3), 582; https://doi.org/10.3390/agronomy12030582
Submission received: 28 December 2021 / Revised: 13 February 2022 / Accepted: 21 February 2022 / Published: 26 February 2022
(This article belongs to the Section Crop Breeding and Genetics)
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Abstract

:
Rice (Oryza sativa L.) and Arabidopsis thaliana (L.) life cycles involve several major phase changes, throughout which MADS-box genes have a variety of functions. MADS-box genes are well recognized for their functions in floral induction and development, and some have multiple functions in apparently unrelated developmental stages. For example, in Arabidopsis, AGL15 and AGL6 play roles in both vegetative development and floral transition. Similarly, in rice, OsMADS1 is involved in flowering time and seed development, and OsMADS26 is expressed not only in the roots, but also in the leaves, shoots, panicles, and seeds. The roles of other MADS-box genes responsible for the regulation of specific traits in both rice and Arabidopsis are also discussed. Several are key components of gene regulatory networks involved in root development under diverse environmental factors such as drought, heat, and salt stress, and are also involved in the shift from vegetative to flowering growth in response to seasonal changes in environmental conditions. Thus, we argue that MADS-box genes are critical elements of gene regulation that underpin diverse gene expression profiles, each of which is linked to a unique developmental stage that occurs during root development and the shift from vegetative to reproductive growth.

1. Introduction

MADS-box genes are a family of transcription factors initially discovered in eukaryotes [1]. All MADS-box proteins have a DNA-binding MADS domain that is ~60 amino acids in length [2]. There are two types of MADS-domain proteins: Type I and Type II. The functions of Type I proteins in plants are mostly unclear [3]. Type II proteins (also known as MIKC-type proteins) are distinguished by the presence of four different domain structures known as the MADS, keratin-like, intervening, and C-terminal domains [4]. MIKC-type MADS-box genes are known to play roles in plant development from vegetative growth to reproduction and to function in various stress responses [5].
The conserved MADS (M) domain and a substantial variable area at the C-terminus are found in Type I proteins, also known as the M-type [6]. In addition to the MADS DNA binding activity, the M domain contains an I domain, a K domain, and a C domain in Type II proteins [7]. The I domain is required for DNA dimerization and specificity [8], whereas the K domain is required for both dimer formation and tetramerization [9,10]. The C domain, a highly variable and largely unstructured domain based on secondary structure prediction, is important in transcriptional activation and the development of higher-order transcription factor (TF) complexes. The C domain also contributes to MADS-box protein–protein interactions [10,11]. Based on the ABCDE model, M-type MADS-box genes have been reported to be involved in plant reproduction, specifically the development and functioning of female gametophytes, the embryo, and the endosperm; MIKC-type MADS-box genes are involved in meristem differentiation, flowering, the determination of floral organ identity, and fruit development [11].
Genetic studies in rice and Arabidopsis have revealed the functions of several MADS-box genes in plant development. The majority of these studies have shown that MADS-box genes are engaged in a variety of important morphological and physiological functions, including gametophyte cell division, root development, the floral transition, and floral organ control [12,13,14]. A typical dicot flower is divided into four parts (whorls): petals, sepals, pistils, and stamens. The generally accepted ABCDE model of floral organs is based on research in dicot species such as Antirrhinum majus and Arabidopsis [15,16]. Different floral organ identities are regulated by various gene combinations, namely A + E (sepals), A + B + E (petals), B + C + E (stamens), C + E (carpels), and D + E (ovules). A great majority of these genes encode MADS-box TF that have been linked to floral organ development [17,18,19,20,21].
In Arabidopsis and rice, MADS-box genes play roles in a variety of developmental processes, including root development and elongation, meristem specification, the flowering transition from vegetative to reproductive stage, endosperm and seed formation, flower development and fertility, and fruit ripening. Several published reviews have reported on their functions from vegetative transition to reproductive development [1,11,22,23,24,25,26,27,28].

2. MADS-Box Gene Expression Profiles during Root Development

MADS-box genes are involved in various components of root development [29], affecting the formation of primary and lateral roots, root density, and root elongation. More than 50 MADS-box genes have been reported to be expressed in Arabidopsis roots [30]. However, little is known about their role in root growth and development during environmental stress exposure. In Arabidopsis, many MADS-box genes of the MIKC type, specifically AGL17-like clade genes, regulate root formation [31,32]. Three members of the AGL17-like clade, namely AGL17, AGL21, and ANR1, are dominantly expressed in Arabidopsis roots [30,33,34,35]. Expression of the nitrate transporter gene NRT2.1 is reduced in the roots of an anr1 mutant line, demonstrating that ANR1 is a positive regulator of NRT2.1 in Arabidopsis [36]. ANR1 stimulates lateral root elongation and increases the fresh weight of shoots in the presence of nitrate by promoting lateral meristem activity [33,37]. In contrast, AtAGL21 increases auxin biosynthesis in the absence of nitrate, promoting lateral root development and elongation [33,37,38]. Intriguingly, ANR1 expression was drastically reduced in nrt1.1 mutants, and these mutants displayed reduced root elongation in nitrate-rich conditions compared with ANR1-knockout plants [33,39]. These findings demonstrate that NRT1.1 functions upstream of ANR1 in local nitrate-induced lateral root development. The key roles of ANR1 in shoot development and in response to nitrate stress remain to be investigated. Overexpression of miR444a decreases shoot development at the seedling stage [40]. Future research should also focus on miR444a and ANR1 may work cooperatively or independently to understand the function of ANR1 under nitrate stress exposure in processes such as shoot development at the seedling stage. The MADS-box TF AGL16 functions as a negative regulator under saline conditions. The agl16 mutants are salt stress-resistant concerning root elongation in comparison to wild-type plants [41]. In Arabidopsis, AGL42 expression has been utilized as a marker for quiescent center identity cells [42], which are the cells at the apices of stele and cortex histogens. However, the loss-of-function mutant has no clear abnormal phenotype in the root, demonstrating that its role in root elongation is unknown. Furthermore, it has been shown that upregulation of AGL42 in the quiescent center and the stele depends on expression of the Brassinosteroid receptor BRI1 on epidermal cells [43].
In rice, AGL17-like clade genes such as OsMADS57 regulate root growth and elongation [29,44,45]. OsMADS57 promotes seminal and adventitious root elongation as well as root to shoot nitrate translocation by influencing the expression of NRT2 [46,47], whereas overexpression of OsMADS57 in rice increases the rate of seed germination and root elongation in response to salt stress conditions [48]. It remains to be determined whether OsMADS57 overexpression promotes tolerance to other environmental stress factors such as drought or heat. Additional research should be conducted to understand the OsMADS57-mediated stress signaling pathway to ultimately strengthen crop tolerance to adverse environmental factors through genome editing technology.
OsMADS50/OsSOC1 (Oryza Sativa SUPPRESSOR OF OVEREXPRESSION OF CO 1) was shown to be important in the control of crown root growth [49]. Plants overexpressing ANR1 showed increased lateral root density and longer lateral roots under control conditions and high nitrogen levels [37]. Furthermore, the rice ANR1 gene family members OsMADS27, OsMADS25, and OsMADS61 are expressed in the root vasculature, and their transcription is modulated differentially in response to NO3− deficiency, NO3− re-supplementation, and a variety of environmental conditions [35,44]. In the presence of nitrate, OsMADS25-overexpression lines showed increases in the number and density of lateral roots while producing significantly larger primary roots; knocking down OsMADS25 had the opposite effect on transgenic rice plants. In addition, OsMADS25 is involved in the regulation of nitrogen transporter genes, demonstrating that this TF is a key regulator of primary and lateral root formation in rice [29]. In the absence of NO3−, overexpression of OsMADS25 resulted in increased lateral root number and primary root length in Arabidopsis compared with wild-type plants. OsMADS27-overexpression lines of rice produced more lateral roots but had shorter primary roots in a NO3− dependent manner. Surprisingly, OsMADS27 overexpression improved salt tolerance, most likely via changes in ABA signaling [50]. Similarly, phosphate deficit and phosphorus supplementation decreased the expression of OsMADS23, OsMADS25, and OsMADS27, but sulphur deficiency increased the expression of these genes significantly [35]. In a yeast two-hybrid experiment, OsMADS27 was shown to bind to a protein implicated in ABA signaling (ABI5; [50]). OsMDP1 encodes a rice AG-like MADS-box protein found in vegetative tissues such as the coleoptile, mature leaf, culm internode, root-elongation zone, and most significantly, the joining area between the leaf blade and the sheath [51]. These findings indicate that several MADS-box genes are critical in root development in many species, and that they respond to environmental conditions through complicated regulatory mechanisms.
Expression of the XAANTAL1 (XAL1; formerly known as AGL12) ortholog OsMADS26 increases with age in rice, and overexpression of this MADS-box gene produces a variety of stress-related responses, including decreased root growth and development [52]. Furthermore, another XAL1 ortholog, LOC_Os08g02070, is expressed preferentially in the rhizome tips in another rice species, Oryza longistaminata [53]. Analysis of the root transcriptome in wild emmer wheat (Triticum turgidum ssp. dicoccoides (Körn.) Thell.) showed that the OsMADS26 ortholog MADS26 was upregulated in a drought-resistant genotype compared to a drought-susceptible line, implying that XAL1 homologs contribute to varying degrees to stress responses and plant development [54]. XAL1 is expressed during the development of various organs, suggesting that it is a key component in complex networks that affect multiple aspects of plant development. Furthermore, it is likely to be implicated in both vegetative and reproductive epidermal cell patterning under different environmental circumstances. However, additional research is required to test this hypothesis. Future research should also focus on protein–protein interactions to understand the function of XAL1 in processes such as root growth.

3. MADS-Box Gene Expression Profiles during Leaf Development in Rice

It has been shown that OsMADS22 and OsMADS55 encode negative regulators of brassinosteroid responses, although their functions differ significantly by developmental stage. OsMADS47 is expressed at high levels in seedling leaves, whereas the transcription of OsMADS55 is highest in mature leaves. As a result of these contrasting expression patterns, OsMADS55 and OsMADS47 are the primary negative regulators of brassinosteroid responses in leaves [55]. In the lamina joint of flag leaves in osmads22 osmads47 osmads55 triple mutant plants, two genes downstream of brassinosteroid synthesis (OsXTR1 and OsBLE3) were upregulated, whereas expression of two brassinosteroid biosynthesis genes (DWARF2 and BRD1) did not significantly change. These findings suggest that genes in the short vegetative phase group interfere with the downstream signaling of OsXTR1 and OsBLE3. Further studies into the interactions between proteins encoded by brassinosteroid-responsive genes and downstream target genes are needed to verify this hypothesis. Transgenic plants with reduced levels of OsMADS55 or OsMADS47 expression show brassinosteroid-related aberrant phenotypes [51].
Gibberellic acid (GA) plays an important role in the regulation of seed germination, leaf shape, and flowering. The gibberellic acid response element, the P-box, is present in the promoter region of PvSOC1, but not in the promoters of SOC1/AGL20 or OsSOC1. The expression of PvSOC1, from the bamboo Phyllostachys violascens, was found to be higher in the leaves of seedlings after GA treatment, indicating a positive response to GA. PvSOC1 appears to be a multifunctional gene that influences leaf development and flowering [56]. PvSOC1 over-expression in Arabidopsis and rice resulted in early flowering, abnormal floral organs, and deformed leaves. However, further research is required to identify the function of PvSOC1 in rice and Arabidopsis.

4. MADS-Box Genes Are Responsible for Inflorescence Branching

The molecular processes driving the evolutionary and developmental dynamics of inflorescences are largely unknown. This is in contrast to the relatively well-understood genetic foundation of floral diversity, where MADS-box TFs have been revealed to play a key role in reproductive processes [57,58]. Grasses (Poaceae), which include cereal crops such as rice, have a different inflorescence design than eudicots such as Arabidopsis. Spikelets, which are physically separate structural components, make up the inflorescence in grasses. In Arabidopsis, it has been reported that both APETALA1 (AP1; formerly known as AGL7) and LEAFY (LFY) inhibit inflorescence branching through interaction with the TERMINAL FLOWER1 (TFL1) gene [59,60,61]. Furthermore, two AP1 homologs, CAULIFLOWER (CAL) and FRUITFULL (FUL; formerly known as AGL8) repress the expression of TFL1. This was verified in ap1 cal ful triple mutants, in which TFL1 functions in conversion of floral meristems into inflorescences [62]. Four MADS-box TFs, SOC1, SVP, AGL24, and SEPALLATA 4 (SEP4), suppress inflorescence branching by directly inhibiting TFL1 expression in Arabidopsis [63]. It was further demonstrated that SVP, SOC1, AGL24, and SEP4 orthologs in rice control panicle branching by modulating TFL1-like genes. These findings demonstrate the existence of a conserved genetic mechanism in flowering plants that determines inflorescence morphology. Studies of the gene expression programs downstream from LFY and AP1 have shown that LFY and AP1 share several target genes and frequently bind to contiguous locations in the Arabidopsis genome [59,64,65,66,67]. The findings of a meta-analysis of existing genome-wide data sets for the two TFs confirmed a common set of target genes [66]. LFY and AP1 regulate the expression of ~200 genes, many of which are known regulators of floral development and branching. These common targets most likely form the molecular foundation of the partial redundancy observed between AP1/CAL and LFY in floral development. However, it is still unknown whether LFY and AP1/CAL work independently or cooperatively in regulating the common target genes. MADS-box genes reported participating in different developmental processes of Arabidopsis are tabulated in Table 1.
TFL1 has an apparently conserved function; mutant rice plants ectopically expressing TFL1 orthologs exhibit massive inflorescence branching [63,68]. It is therefore unknown how TFL1-like genes are expressed in flowering plants to define specific types of inflorescence design. In eudicots and monocots, TFL1-like genes are needed for meristem indeterminacy [68,69,70,71]. Upregulation of the TFL1 homologs RCN1 and RCN2 in rice and ZCN1 to ZCN6 in maize results in a branched inflorescence [68,70]. Future research should examine the relationships between these MADS-box genes and other inflorescence characteristics. For example, a study of OsMADS34, FLORAL ORGAN NUMBER4 (FON4), and LAX PANICLE1 (LAX1) showed superior phenotypes of osmads34 fon4 and osmads34 lax1 double mutants compared with the single mutants; OsMADS34 interacts with LAX1 and FON4 to regulate many features of inflorescence shape, branching, and meristem activity. Furthermore, a double mutant combining the sterile lemma-defective and osmads34 mutants had longer and wider sterile lemmas, indicating that ELONGATED EMPTY GLUME (ELE) and OsMADS34 work together to control sterile lemma development. OsMADS34 and OsMADS15 may also cooperate to control the development of sterile lemmas [72].
Table
Table 1. Roles of MADS-box genes in the development of Arabidopsis thaliana (L.).
Table 1. Roles of MADS-box genes in the development of Arabidopsis thaliana (L.).
GeneLocus IDFunctionReference
STK/AGL11At4g09960Ovule development [19,30]
XAL1/AGL12At1g71692Root development; transition to flowering[73]
AGL15AT5g13790Embryogenesis; sepal and petal longevity; flowering repressor with AGL18; fruit maturation[74,75,76]
AGL18At3g57390Flowering repressor with AGL15[77]
AGL16At3g57230Number and distribution of stomata[78]
AGL17At2g22630Root formation; Flowering activator[31,32,79]
AGL6At2g45650Flowering activator; lateral organ development[80]
FLC/AGL25At5g10140Juvenile-to-adult transition; flowering repressor; flowering initiation, flower organ development[81,82]
MAF2/AGL31At5g65050Flowering repressor[83]
AGL19At4g22950Flowering activator[84]
FUL/AGL8At5g60910Meristem identity specification; annual life cycle regulator with SOC1; fruit development[62,85]
AP1/AGL7At1g69120Homeotic A-class gene; meristem identity specification[62]
AGL24At4g24540Flowering activator[86]
AGL23At1g65360Embryo sac development[87]
AGL28At1g01530Flowering activator[88]
AGL42At5g62165A marker for quiescent center identity cells[42]
AGL62At5g60440Central cell development[89]

5. Communicating Role from Vegetative to Flowering Transition

One of the most basic developmental alterations in the life cycle of flowering plant species is the change from the vegetative to the reproductive stage [90]. Several investigations have shown that flower growth in higher eudicot angiosperms is controlled by a hierarchical network of regulatory genes [91]. Late- and early-flowering genes, which are regulated by diverse environmental factors such as light quality, day length, and heat, are at the top of the hierarchy. These genes may regulate the conversion from vegetative to flowering development by activating meristem identity genes in response to environmental factors.
In Arabidopsis, SPLs are upstream activators and downstream targets of the floral-transition MADS-box genes. Photoperiod strongly affects transcription of three miR156-targeted SPLs (SPL3, SPL4, and SPL5), which are downregulated in short-day (SD) conditions and upregulated in long-day (LD) conditions [92]. Another study demonstrated that SPL3, SPL4, and SPL5 act in a dependent manner upon two related BELL1-like homeodomain proteins, PENNYWISE (PNY) and POUND-FOOLISH (PNF), which act to specify floral meristems through downregulation of miR156 [93]. This effect was verified in pny pnf double mutants, in which expression levels of AP1 and three SPLs were drastically reduced and plants were not able to produce flowers in response to inductive conditions. Further research is needed to determine whether miR156 regulation of flowering is dependent on the expression of PNY and PNF. SPL3 is regulated directly by SOC1 [94]; SPL4 expression is greatly decreased in soc1 ful double mutants in the SAM [94,95]. This interconnected feed-forward loop may promote the transition from vegetative to reproductive development. The reduction in miR156 accumulation in agl15 agl18 double mutants demonstrates that AGL15 and AGL18 function as co-regulators with miR156 in the determination of flowering time in Arabidopsis. AGL15 and AGL18 interact with putative CArG motifs in the MIR156 promoter both in vitro and in vivo [96,97,98].
In Arabidopsis, GA enhances the transition from vegetative to flowering development by degrading transcriptional repressors DELLAs. However, the underlying processes are still unknown. DELLA proteins interact with microRNA156-targeted SPL TFs to repress transcriptional activation of MADS-box genes such as AP1, SOC1, and FUL, plant-specific LEAFY (LFY) TFs, and miR172 [99,100,101,102].
In rice, the MADS protein family has 75 members, which are mainly divided into five categories: MIKCC, MIKC, Mα, Mβ, and Mγ. Most are involved in regulating the formation of floral organs [103] but MADS-box TFs are also related to several processes in vegetative plant growth and development. There have been no reports of rice genes with substantial similarity to FLOWERING LOCUS C (FLC; formerly known as AGL25) outside of the MADS genes; however, the MADS-box gene OsMADS50/OsSOC1 has a similar sequence to that of AtSOC1. It has been shown that OsMADS50/OsSOC1 is transcribed at a somewhat higher level during the floral transition than during vegetative growth, and that OsMADS50/OsSOC1 over-expression causes transgenic Arabidopsis plants to flower early [104].
OsMADS50 and OsMADS56 encode MIKCC-type proteins that are homologs of Arabidopsis SOC1, and the expression of both is affected by the circadian clock [105,106]. Under LD conditions, OsMADS50 and OsMADS56 have opposing effects on flowering time in rice. OsMADS56 is a flowering suppressor gene, whereas OsMADS50 can promote flowering. In Arabidopsis, SOC1 is a downstream target gene of CONSTANS (CO), whereas OsMADS50 and OsMADS56 are upstream of the flowering time regulatory network in rice. In addition, expression analyses and interaction experiments for related genes have shown that they also control flowering in rice by forming an antagonistic complex to regulate the common downstream gene OsLFL1-Ehd1 (Early heading date 1). They are also independent of flowering regulation by Hd1, SE5, and RID1/OsId1/Ehd2 [107].
Rice flowering time is determined by the expression levels of three additional SEP-like MADS-box genes, OsMADS7, OsMADS5, and OsMADS8 [108,109]. TaMADS1, a wheat homolog of rice OsMADS24, regulates floral development, and ectopic expression of TaMADS1 induces early flowering in Arabidopsis [5]. Overexpression of TaMADS1 also induces early flowering and abnormal floral organ development in Arabidopsis [110]. Furthermore, TaAGL6 overexpression also promotes early flowering in Arabidopsis [111]. Several studies have shown that specific MADS-box genes in wheat affect flowering; however, compared to species such as Arabidopsis and rice, there is still a great deal to be uncovered.
OsMADS14, OsMADS15, and OsMADS18 are all AP1/FUL genes that encode flowering promoting factors that function downstream of OsMADS50 [105,112]. RNAi-mediated suppression of these three genes results in a slight delay in the reproductive transition [112]. OsMADS51 and OsMADS65 are MADS-box genes of the MIKCC type, and OsMADS51 encodes a TF that promotes flowering under SD conditions [113].

6. Molecular Events at the Shoot Apical Meristem in Response to Photoperiodic Induction

Arabidopsis Florigen gene FLOWERING LOCUS T (FT) transcription and migration of the encoded protein to the apical meristem are induced by inductive photoperiods, which alter the regulation of genes involved in inflorescence formation. The FT–FD complex in Arabidopsis shoot apical meristems is directed to the promoter of AP1, which encodes a MADS-box TF required for flowering initiation and flower development [114]. Additional MADS-box TFs that are necessary for FT-stimulated flowering, such as SOC1, is upregulated early in the floral conversion. In Arabidopsis, SOC1 is regulated by two flowering regulators, CO and FLC, which function as a floral activator and repressor, respectively [100,115,116]. Other genes, such as FD PARALOGUE (FDP), may share FD function [114,117]. TWIN SISTER OF FT (TSF) and FD activation by N6-benzylaminopurine treatments and physical interaction between TSF and FD or FDP proteins [118] demonstrated that a TSF/FD(P) complex is involved in promoting flowering [119]. Expression levels of both TSF and FDP increased simultaneously in the leaves after N6-benzylaminopurine application, suggesting that the TSF/FD complex may function in leaves. This was a surprising finding because FD is primarily expressed in Arabidopsis root and shoots apices [114,117]. However, it has also been reported that FD is necessary for FT to increase gene expression in leaves [120], and the FD homolog SPGB (an AG-box factor called SPGB with a specific 14-3-3 adapter protein) is expressed in both leaves and shoot apices in tomato [121]. The discovery of the TSF protein in phloem sap [122] demonstrates that it could be a systemic signal. This indicates that N6-benzylaminopurine initiates flowering by promoting transcription of TSF, which then travels to the meristem and stimulates SOC1 and AP1 transcription by contact with FD or FDP. Prior to the floral transition, flowering repressors are also present in the meristem. FLC and SVP encode MADS-box proteins that significantly delay flowering [99,123,124,125]. These proteins form a heterodimer that is hypothesized to suppress SOC1 transcription [126,127]. However, a study revealed that the flowering time was increased in flc svp double mutants compared with either single mutant, implying that these proteins have both unique and overlapping functions. Both proteins delay flowering by suppressing FT and TSF or SOC1 transcription in the leaf and meristem, respectively [118,128,129]. The MADS-box floral activator FUL functions redundantly with SOC1, as demonstrated by the phenotypes of soc1 and ful single mutants [62,85,95]. The soc1 ful double mutants had increased abnormalities in floral initiation and reproductive growth maintenance.
Both Hd3a and OsFD1 expression are necessary in rice protoplasts to stimulate the expression of OsMADS15, a homolog of AP1. The hd3a mutants that cannot bind to 14-3-3 proteins and 14-3-3 knockouts are unable to stimulate OsMADS15 transcription [130]. Rice has a counterpart to SOC1 that is regulated by OsMADS50 and has been found to be necessary for flowering induction [105]. The MADS-box genes OsMADS14, OsMADS18, and OsMADS34 are required for normal inflorescence development, and their expression is elevated in the SAM during the flowering transition [112]. These findings point to the presence of a conserved floral initiation strategy in plant apical meristems, in which florigens interact with FD-like TFs to induce transcription of several MADS-box genes slightly earlier in the transition from vegetative growth to flowering. This core developmental plan is linked to additional regulatory layers in order to fine-tune and sustain the floral transition [131,132]. Figure 1 includes several MADS-box genes responsible for root, seedling, flowering, ovule, and pollen grain development of Arabidopsis.

7. Floret Pattern Initiation and Development

Although key aspects related to the genesis and diversity of flowers remain largely unknown, the genetic control of flower shape has been widely investigated in diverse crop species [139].
MADS-box proteins regulate inflorescence development by establishing a higher-order combination, and rice has a large number of MADS-box genes [140]. The four putative A-class genes in rice are OsMADS14, OsMADS18, OsMADS15, and OsMADS20 [140,141]. The double knockouts osmads14 osmads15 exhibit genuine homozygous genetic variation, with abnormalities in the first and second whorls. The A-class gene OsMADS15 has been demonstrated to be involved in palea development in a previous study [142]. Triple mutant osmads14 osmads15 osmads18 plants show no phenotypic changes in floral development [112]. Rice also has two B-class orthologs, OsMADS2 and OsMADS4. It was demonstrated that osmads4 mutant plants have normal lodicule and stamen characteristics, whereas transgenic plants in which OsMADS2 silenced show differences in the lodicules but not in the stamens. Instead of lodicules and carpel-like organs, transgenic plants lacking both OsMADS4 and OsMADS2 have palea-like structures [143,144,145,146]. The C-class gene OsMADS3 is associated with meristem function in early and late floral development [147], whereas the D-class gene OsMADS13 is required for ovule identity [148]. OsMADS3 is mainly involved in the presumptive region of stamen and ovule primordia just before the initiation of these organs [148]. Furthermore, OsMADS58 is upregulated in reproductive organs. However, loss-of-function mutants for OsMADS3 have abnormal stamens but normal carpel development. The osmads58 mutant has decreased floral meristem determinacy instead of floral organ abnormalities. When OsMADS3 and OsMADS58 were silenced, the male and female reproductive organs were homeotically transformed into palea/lemma-like organs and lodicules [148]. It is possible that differences in the proteins that interact with OsMADS3 and OsMADS58 resulted in functional diversity. The precise molecular mechanism behind the functional diversification of OsMADS3 and OsMADS58 remains an interesting subject for future study. Overexpression of SVP-group MADS-box genes produces flower deformities and floral reversion in Arabidopsis and barley [135,149], and Sentoku et al. [150] showed that OsMADS22-overexpressing plants exhibit comparable traits. Fertility and panicle length were also affected in OsMADS22-overexpressing plants. Similarly, OsMADS55 overexpression lines showed reduced fertility, shorter panicles, and malformed flowers [55].
OsMADS1, a SEP-like subfamily homolog, is expressed in the lemma and palea and affects floral meristem identity [151]. The interaction of OsMADS1 with B-, C-, and D-class proteins has been confirmed by yeast two-hybrid analysis; this interaction produces a heterodimeric complex that influences floral meristem determinacy. The interaction of OsMADS1 with OsMADS3 and OsMADS58 to determine stamen identity and prevent spikelet meristem reversion has been demonstrated both in vitro and in vivo. Furthermore, OsMADS1 is a positive regulator of OsMADS17 during floral development, whereas OsMADS1 and OsMADS13 function in meristem determinacy through partially independent pathways. These findings suggest that OsMADS1 collaborates with another unknown regulator to modulate meristem determinacy. OsMADS1 and OsMADS34 are involved in the development of the four whorls of the floral organs as well as the development of spikelet meristems [152]. This finding has been verified in osmads34 osmads1 double mutants, demonstrating that OsMADS34 determines rice floral organ identity in combination with OsMADS1.
The S-clade genes OsMADS62 and OsMADS63, as well as the P-clade gene OsMADS68, are MIKC-type genes in rice. All three MIKC-type genes were found to be expressed in the late developmental stages of pollen. Proteins from the different sub-clades form heterodimers, which is very similar to the process that occurs in Arabidopsis [153,154]. OsMADS62, OsMADS63, and OsMADS68 transcripts are found in pollen but not in the anther walls. These findings show that rice MIKC-type genes are only expressed in pollen at late developmental stages, implying that they participate in pollen maturation [153]. The osmads62 osmads63 osmads68 triple knockout mutants have a male-sterile phenotype [155], similar to that of the rice immature pollen 1 (rip1) mutant. RIP1 functions in normal pollen development, and rip1 mutants have a male-sterile phenotype and abnormal intine layers [156]. Furthermore, RIP1 is not expressed in osmads62 osmads63 osmads68 triple mutants. It has been predicted that RIP1 may function upstream of OsMADS62, OsMADS63, and OsMADS68, or in a different pathway containing those three MADS genes. Further study is required to verify this prediction. MADS-box genes reported participating in different developmental processes of rice are tabulated in Table 2.
In Arabidopsis, several genes play critical roles in floret development. TM5, FBP2, and other AGL2-like genes are expressed in the petals and stamens [133,157,158]. In addition, the AGL2-like genes serve as facilitators between the floral organ identity and floral meristem genes in Arabidopsis [133,134]. SEEDSTICK (STK; formerly known as AGL11), SHATTERPROOF (SHP) 1, and SHP2 are three D-class genes in Arabidopsis that have overlapping functions in regulating ovule development [19,159,160]. This redundancy has been verified through phenotyping single and triple mutants. XAL1/AGL12, the sole member of the subfamily in Arabidopsis, is expressed in flowers [34].
Table
Table 2. MADS-box genes have different functions in different parts of the rice plant.
Table 2. MADS-box genes have different functions in different parts of the rice plant.
GeneGenomic IdentityFunctionReference
OsMADS1LOC_Os03g11614Involved in the early stages of rice floret development[161]
OsMADS3LOC_Os01g10504Meristem function in early and late floral development, involved in the formation of stamens and ovules[147]
OsMADS5LOC_Os06g06750Expressed strongly across a broad range of reproductive stages and tissues[162]
OsMADS7LOC_Os08g41950Improves the stability of rice amylose content at high temperature[163]
OsMADS8LOC_Os09g32948Inflorescence branch meristems[152]
OsMADS13LOC_Os12g10540Ovule identity[148]
OsMADS14LOC_Os03g54160Flowering activator[112]
OsMADS15LOC_Os07g01820Flowering activator[112]
OsMADS16LOC_Os06g49840Regulation of floral organ development and pollen formation[164]
OsMADS17LOC_Os04g49150Regulates hormone signaling and floral identity[103]
OsMADS18LOC_Os07g41370Flowering activator[112]
OsMADS25LOC_Os04g23910OsMADS25 overexpression results in more lateral roots[29]
OsMADS26LOC_Os08g02070Expressed in rice leaves and inflorescences[165]
OsMADS27LOC_Os02g36924Produced more lateral roots[50]
OsMADS29LOC_Os02g07430Involved in programmed cell death (PCD) in the developing embryonic cell nuclear region[166,167]
OsMADS34LOC_Os03g54170Involved in development of the inflorescence[152]
OsMADS50LOC_Os03g03100Flowering activator[107]
OsMADS51LOC_Os01g69850Flowering activator[113]
OsMADS56LOC_Os10g39130Flowering suppressor[107]
OsMADS57LOC_Os02g49840Expressed in root vasculature[35,44]
OsMADS61LOC_Os04g38770Expressed in root vasculature[35,44]
OsMADS62LOC_Os08g38590Rice anther development[168]
OsMADS63LOC_Os06g11970Rice anther development[168]
OsMADS68LOC_Os11g43740Pollen development[153]
OsMADS77LOC_Os09g02780Endosperm development[169]
OsMADS87LOC_Os03g38610Endosperm development[170]
OsMADS89LOC_Os01g18440Endosperm development[170]

8. MADS-Box Genes Play an Important Role in Seed Setting and Development

There are several key reproductive phases in the life cycle of an angiosperm that lead to sufficient seed setting. Pollination and subsequent fertilization of the ovules in the flower are key events to produce viable seeds. A large number of MADS-box mutants in flowering plant species implies that members of this gene family perform important regulatory functions in diverse conditions during seed development [34,171]. AGL21 inhibits seed germination in Arabidopsis under osmotic stress conditions in addition to its function in lateral root development [172]. Seeds of AGL21 loss-of-function lines germinate at a lower rate than wild-type plants under salt stress (150 mM NaCl), severe osmotic stress (300 mM mannitol), and ABA treatment. AGL21 controls the activity of ABI5, which is required for ABA signaling, and ABI5 is required for AGL21-regulated seed germination. AGL15 is involved in seed formation, and overexpression lines show delayed silique maturity and seed desiccation [14].
In the rice genome, the MADS-box genes are members of a large TF family containing almost 75 members [103]. The majority have reported involvement in floral organ development, and some are important for endosperm development [63,173]. For example, OsMADS29 is involved in seed development [166,167,174]; OsMADS87 is involved in endosperm cellularization and seed size regulation [175]. Heat treatment (from moderate to severe) for 48 h after fertilization reduces the expression of three rice MADS-box genes, OsMADS82, OsMADS87, and OsMADS89, leading to reduced size and viability of rice seeds [175]. This observation led researchers to investigate OsMADS87 in mutant rice lines [175]. They discovered that RNAi lines maintained under ideal conditions showed increased endosperm cellularization (the process during which the endosperm exits the multi-nucleate stage and initiates cytokinesis) and decreased grain size due to reduced OsMADS87 expression. However, OsMADS87 overexpression was found to have no effect on endosperm cellularization but resulted in larger mature seeds. When heat-stressed plants (35 °C) were compared to control plants, the overexpression and wild-type lines had smaller seeds, but the RNAi lines were unaffected. It has also been reported that OsMADS87 expression is temperature sensitive and negatively associated with increased expression of OsFIE1, the only PRC2 complex member with heat sensitivity in ripening rice seeds [176]. The Arabidopsis homolog PHE1 is responsible for early endosperm development, although its role in seed size development is unknown. Moreover, rice plants with both stable amylose concentration at high temperatures and spikelet fertility can be obtained by inhibiting OsMADS7 function during endosperm development [163]. These findings suggest that OsMADS7 is a promising candidate gene for maintaining stable amylose contents in rice at high temperatures. Specifically reducing the expression of OsMADS7 during rice endosperm formation may be an effective strategy for breeding high-quality rice that is tolerant of temperature stress.
Several key genes are expressed in Arabidopsis during seed development. AGL62 controls the timing of endosperm cellularization; this process occurs prematurely in loss-of-function of agl62 mutants, limiting normal embryo development [89]. AGL23 has been linked to the formation of both female gametophytes and seeds. After megasporogenesis, agl23 mutant ovules are partially inhibited, implying that AGL23 plays a function in early embryo sac development [87]. AGL28 is a unique type I MADS-box gene because, in addition to the embryo sac development, it is expressed in a variety of organs during seed development [88].
It is worth mentioning that B-sister genes, a novel collection of MIKC MADS-box genes, are close relatives of B-type genes [31]. B-sister proteins are found in both gymnosperm and angiosperm species [166,177,178,179]. B-sister genes are important for ovule and seed establishment in Arabidopsis [31,180,181]. An Arabidopsis B-sister gene, ARABIDOPSIS BSISTER (ABS), controls endothelial growth and proanthocyanidin (PA) accumulation in the seed coat [181,182,183]. GORDITA (GOA), another Arabidopsis B-sister gene, regulates ovule coat production and fruit longitudinal development in a novel and non-redundant manner [184].
The MADS-domain TF STK is involved in ovule identity determination [183] and transmission tract development [185,186], and also plays a pivotal role in seed abscission [187,188]. The stk mutants are reported to have smaller seeds compared with wild-type plants [19]. STK increases cell cycle progression in seeds via E2Fa, a pathway that is considered critical for seed size regulation [189]. It has also been reported that STK is necessary for endothelium differentiation in conjunction with ABS [181]. In Arabidopsis thaliana, mutations in XYLOSIDASE1 (XYL1) have a significant impact on seed germination, seed size, and fruit development. The MADS-box TF STK regulates XYL1 expression, which is directly involved in developing seeds and fruit [190]. Figure 2 includes several MADS-box genes responsible for root, seedling, flowering, ovule, and pollen grain development of rice.

9. Concluding Remarks and Future Perspectives

Alterations in gene regulation are one of the most significant routes leading to phenotypic changes. Due to their capacity to affect gene expression, TFs can cause developmental shifts. TFs have also been shown to function in regulating responses to environmental stress throughout the plant life cycle. Furthermore, small changes in the expression of a few key TFs have been shown to impact the development of numerous processes and structures. Specific mutants have shown that TFs from the MADS-box gene family are important regulators of Arabidopsis development at all growth stages. Multiple studies have also shown that MADS-box genes play important roles in controlling plant responses and tolerance to a wide variety of abiotic stimuli, highlighting their relevance as integrators of environmental signals and endogenous hormones in a taxonomically diverse range of plant species.
Several functional investigations have been undertaken into the developmental roles of MADS-box genes in rice; however, a great deal remains unknown. Gene knockdown mutants (single and higher-order) should be identified to expose the functional characteristics of MADS-box genes throughout the development of rice plants. In addition, the interactions of MADS-domain proteins with other proteins will aid in determining the molecular functions of MADS-box genes in rice. The functional diversification process of duplicated MADS-box genes, including OsMADS2, OsMADS3, OsMADS4, and OsMADS58, should also be addressed. Such an investigation, along with analogous observations in other grass species, will contribute to the understanding of how grass flowers and inflorescences evolved and diversified.
The significance of MADS-box genes has mainly been investigated in the model plant Arabidopsis thaliana. The literature reviewed here, however, demonstrates that our understanding is quickly evolving with respect to MADS-box genes that govern flower development in rice due to the novel functional genomics methods now possible. The rapid advances in this area were primarily a result of knowledge gained in Arabidopsis [192]. Many mutant populations based on transposons and T-DNA insertions are accessible for functional investigations of rice genes [193,194]. CRISPR-Cas9 systems have been widely exploited today as tools for genome editing in a variety of plant species [195,196]. A technique that uses chemical mutagens such as ethyl methanesulfonate (EMS) can also be used to study gene function via reverse genetics [197,198,199].

Author Contributions

Conceptualization, L.S., A.S. and R.A.; supervision, W.W., L.C. and S.C.; writing original draft, L.S.; writing—review and editing, L.S. and W.W. All authors have read and agreed to the published version of the manuscript.

Funding

This work was funded by the National Natural Science Foundation of China (grant numbers 31871604, 32071996, and 31961143016), the Fundamental Research Funds of Central Public Welfare Research Institutions (grant number CPSIBRF-CNRRI-202102), the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (grant number CAAS-ASTIP2013-CNRRI), and Hainan Yazhou Bay Seed Lab (grant number B21HJ0219).

Data Availability Statement

Not applicable.

Acknowledgments

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

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Figure 1. The biological roles of MADS-box genes in controlling the development of various vegetative and reproductive tissues of the model plant Arabidopsis thaliana. Many MADS-box genes mediate the transition to flowering. Some MADS-box genes are involved in flowering time, such as AGL2 [133,134], AGL6 [80], FUL/AGL8 [62,85], XAL1/AGL12 [73], AGL15 [74,75,76], AGL17 [79], AGL18 [77], AGL19 [84], SOC1/AGL20 [100], AGL24 [135], FLC/AGL25 [81,82], AGL28 [88], and MAF2/AGL31 [83]. MADS-box genes are also involved in root growth (e.g., XAL1/AGL12, AGL16, AGL17, AGL21, and AGL42) [31,32,42,73,78,79,136], pollen maturation and tube growth (AGL65/66/104) [137], ovule development (e.g., STK/AGL11, AGL23, AGL62) [19,30,87,89], and seed development (e.g., AGL23, AGL80) [87,138].
Figure 1. The biological roles of MADS-box genes in controlling the development of various vegetative and reproductive tissues of the model plant Arabidopsis thaliana. Many MADS-box genes mediate the transition to flowering. Some MADS-box genes are involved in flowering time, such as AGL2 [133,134], AGL6 [80], FUL/AGL8 [62,85], XAL1/AGL12 [73], AGL15 [74,75,76], AGL17 [79], AGL18 [77], AGL19 [84], SOC1/AGL20 [100], AGL24 [135], FLC/AGL25 [81,82], AGL28 [88], and MAF2/AGL31 [83]. MADS-box genes are also involved in root growth (e.g., XAL1/AGL12, AGL16, AGL17, AGL21, and AGL42) [31,32,42,73,78,79,136], pollen maturation and tube growth (AGL65/66/104) [137], ovule development (e.g., STK/AGL11, AGL23, AGL62) [19,30,87,89], and seed development (e.g., AGL23, AGL80) [87,138].
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Figure 2. The biological roles of MADS-box genes in controlling the development of various vegetative and reproductive structures in the rice plant. Many MADS-box genes mediate the transition to flowering induction (e.g., OsMADS1 [161], OsMADS3 [147], OsMADS5 [162], OsMADS7 [163], OsMADS8 [152], OsMADS14 [112], OsMADS15 [112], OsMADS17 [103], OsMADS18 [112], OsMADS26 [165], OsMADS34 [152], OsMADS50 [107], OsMADS51 [113], and OsMADS56 [107]). MADS-box genes involved in tiller development include OsMADS26 [191] and OsMADS57 [50]. Those involved in root development include OsMADS25 [44], OsMADS26 [191], OsMADS27 [50], OsMADS50 [49], OsMADS57, and OsMADS61 [38,44]; in ovule growth, OsMADS1 [161] and OsMADS13 [148]; in pollen grain maturation, OsMADS3 [147], OsMADS16 [164], OsMADS62, OsMADS63 [168], and OsMADS68 [153]; and in seed and endosperm development, OsMADS1 [161], OsMADS29 [166,167,174], OsMADS77 [169], OsMADS82 [175], OsMADS87 [170,175], and OsMADS89 [170,175].
Figure 2. The biological roles of MADS-box genes in controlling the development of various vegetative and reproductive structures in the rice plant. Many MADS-box genes mediate the transition to flowering induction (e.g., OsMADS1 [161], OsMADS3 [147], OsMADS5 [162], OsMADS7 [163], OsMADS8 [152], OsMADS14 [112], OsMADS15 [112], OsMADS17 [103], OsMADS18 [112], OsMADS26 [165], OsMADS34 [152], OsMADS50 [107], OsMADS51 [113], and OsMADS56 [107]). MADS-box genes involved in tiller development include OsMADS26 [191] and OsMADS57 [50]. Those involved in root development include OsMADS25 [44], OsMADS26 [191], OsMADS27 [50], OsMADS50 [49], OsMADS57, and OsMADS61 [38,44]; in ovule growth, OsMADS1 [161] and OsMADS13 [148]; in pollen grain maturation, OsMADS3 [147], OsMADS16 [164], OsMADS62, OsMADS63 [168], and OsMADS68 [153]; and in seed and endosperm development, OsMADS1 [161], OsMADS29 [166,167,174], OsMADS77 [169], OsMADS82 [175], OsMADS87 [170,175], and OsMADS89 [170,175].
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Shah, L.; Sohail, A.; Ahmad, R.; Cheng, S.; Cao, L.; Wu, W. The Roles of MADS-Box Genes from Root Growth to Maturity in Arabidopsis and Rice. Agronomy 2022, 12, 582. https://doi.org/10.3390/agronomy12030582

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Shah L, Sohail A, Ahmad R, Cheng S, Cao L, Wu W. The Roles of MADS-Box Genes from Root Growth to Maturity in Arabidopsis and Rice. Agronomy. 2022; 12(3):582. https://doi.org/10.3390/agronomy12030582

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Shah, Liaqat, Amir Sohail, Rafiq Ahmad, Shihua Cheng, Liyong Cao, and Weixun Wu. 2022. "The Roles of MADS-Box Genes from Root Growth to Maturity in Arabidopsis and Rice" Agronomy 12, no. 3: 582. https://doi.org/10.3390/agronomy12030582

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