Photoredox-Catalyzed Acylation/Cyclization of 2-Isocyanobiaryls with Oxime Esters for the Synthesis of 6-Acyl Phenanthridines
Round 1
Reviewer 1 Report
Dear Authors:
This paper, presented a very interesting report for Photoredox-Catalyzed Acylation/Cyclization of 2‑Isocyanobiaryls with Oxime Esters for the Synthesis of 6-Acyl Phenanthridines. The overall structure and writing indeed require a significant improvement. I really would like to see this article in Catalysts after major revisions.
1. The abstract section is poor and should be re-written. An abstract should be included a brief summary of article about “experiment conditions”, “results” and “advantages” (no any discussions and no any conclusions), then it help the reader quickly ascertain the paper's purpose.
2. The number of keywords should be at least 5.
3. In the introduction, it is better to provide references about recently used photocatalysts.
4. In table 1, entries 1 and 26, explain what is meant by none? Solvent-free or catalyst-free, etc.? Entries 23, 24 and 25 also need full explanations.
5. Tables 2 and 3 need the melting point of synthesized compounds.
6. It should also be noted whether the yield is isolated or not.
7. Apart from N2, you should also check the reaction in Argon and air oxygen and present the results in the Table 1.
Best Regards
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
Li and co-workers developed a methodology for the synthesis of 6-acyl penanthridines using photoredox catalysis. This methodology was successfully applied to a wide range of substrates.
Comments/questions:
Page 2, line 67: Change "To our delighted" to To our delight
Page 3, line 88: Consider using term "large-scale" for 1 mmol scale
Page 4, line 107: Change "could be obtain" to could be obtained
Page 6, lines 139,140: = −1.73 versus SCE and −1.45 versus SCE what is the unit V?
Page 7, line 177: which solvent did you use? hexane or PE?
Page 7, line 178: Change "80:1 to 60:1" to 80:1 to 40:1
Page 7, line 188: The HRMS data do not match with the structure. Copy/paste error?
Author Response
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Author Response File: Author Response.pdf
Reviewer 3 Report
Thank you Liu and coworkers for presenting the interesting work, which shows a general method for activate the isocyanobiaryls. I suggest to accept this work after revises. The term “blue LED” is quite general, please also mention the wavelength range and provide the spectra for better reproducibility. When considering the optimization of the catalysts, please also mention its overlap with the light source. Some catalysts are harming the reaction, please give reasonings. Table 2 seems have incorrect drawing one R1 and R2 positions.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Dear Authors
I read the revised manuscript. In my opinion, the manuscript is now accepted for publication in the journal.
Best Regards
