Sedentary Behaviour—A Target for the Prevention and Management of Cardiovascular Disease
Abstract
:1. Introduction
- a)
- The association of total sedentary time and patterns of accumulating sedentary time with CVD risk markers, CVD incidence and mortality;
- b)
- Experimental evidence regarding the acute effects of reducing and breaking up sedentary time on CVD risk markers; and,
- c)
- The effectiveness of interventions targeting sedentary behaviour on CVD risk.
2. Associations of Sedentary Behaviour with Cardiovascular Disease Risk Markers
2.1. Total Sedentary Time
2.2. Sedentary Time Bouts and Breaks
3. Sedentary Behaviour and Cardiovascular Disease Incidence and Mortality
3.1. TV Viewing
3.2. Total Sedentary Time and Independence from Physical Activity
4. Effects of Breaking up Sedentary Time on Cardiovascular Risk Markers
4.1. Effects of Breaking up Sedentary Time on Postprandial Glucose and Insulin
4.2. Effects of Breaking up Sitting on Postprandial Lipids
4.3. Effects of Breaking up Sitting on Blood Pressure
5. Effects of Reducing and Breaking up Sitting in Free-Living Conditions
6. Interventions to Reduce Sedentary Behaviour and Improve Cardiovascular Health
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Stewart, J.; Manmathan, G.; Wilkinson, P. Primary prevention of cardiovascular disease: A review of contemporary guidance and literature. JRSM Cardiovasc. Dis. 2017, 6, 2048004016687211. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- World Health Organization. Cardiovascular Diseases (CVDs). 2017. Available online: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (accessed on 1 February 2022).
- British Heart Foundation. Heart and Circulatory Disease Statistics 2022. Available online: https://www.bhf.org.uk/-/media/files/research/heart-statistics/bhf-statistics-compendium-2022.pdf?rev=79c10677e14141ee886970ac9808f1db&hash=79A256DC5330081D89E5D5124E1F60EC (accessed on 15 August 2022).
- Scott, J. Pathophysiology and biochemistry of cardiovascular disease. Curr. Opin. Genet. Dev. 2004, 14, 271–279. [Google Scholar] [CrossRef] [PubMed]
- Marchio, P.; Guerra-Ojeda, S.; Vila, J.M.; Aldasoro, M.; Victor, V.M.; Mauricio, M.D. Targeting early atherosclerosis: A focus on oxidative stress and inflammation. Oxidative Med. Cell. Longev. 2019, 2019, 8563845. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bellettiere, J.; LaMonte, M.J.; Evenson, K.R.; Rillamas-Sun, E.; Kerr, J.; Lee, I.-M.; Di, C.; Rosenberg, D.E.; Stefanick, M.L.; Buchner, D.M.; et al. Sedentary behavior and cardiovascular disease in older women: The Objective Physical Activity and Cardiovascular Health (OPACH) Study. Circulation 2019, 139, 1036–1046. [Google Scholar] [CrossRef] [PubMed]
- Powell, C.; Herring, M.P.; Dowd, K.P.; Donnelly, A.E.; Carson, B.P. The cross-sectional associations between objectively measured sedentary time and cardiometabolic health markers in adults—A systematic review with meta-analysis component. Obes. Rev. 2018, 19, 381–395. [Google Scholar] [CrossRef]
- Wilmot, E.G.; Edwardson, C.L.; Achana, F.A.; Davies, M.J.; Gorely, T.; Gray, L.J.; Khunti, K.; Yates, T.; Biddle, S.J.H. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: Systematic review and meta-analysis. Diabetologia 2012, 55, 2895–2905. [Google Scholar] [CrossRef]
- Mozaffarian, D.; Wilson, P.W.; Kannel, W.B. Beyond established and novel risk factors: Lifestyle risk factors for cardiovascular disease. Circulation 2008, 117, 3031–3038. [Google Scholar] [CrossRef] [Green Version]
- Tremblay, M.S.; Aubert, S.; Barnes, J.D.; Saunders, T.J.; Carson, V.; Latimer-Cheung, A.E.; Chastin, S.F.M.; Altenburg, T.M.; Chinapaw, M.J.M. Sedentary behavior research network (SBRN)–terminology consensus project process and outcome. Int. J. Behav. Nutr. Phys. Act. 2017, 14, 1–17. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bailey, D.P.; Hewson, D.J.; Champion, R.B.; Sayegh, S.M. Sitting time and risk of cardiovascular disease and diabetes: A systematic review and meta-analysis. Am. J. Prev. Med. 2019, 57, 408–416. [Google Scholar] [CrossRef]
- Dunstan, D.W.; Dogra, S.; Carter, S.E.; Owen, N. Sit less and move more for cardiovascular health: Emerging insights and opportunities. Nat. Rev. Cardiol. 2021, 18, 637–648. [Google Scholar] [CrossRef]
- Grøntved, A.; Hu, F.B. Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: A meta-analysis. JAMA 2011, 305, 2448–2455. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Patterson, R.; McNamara, E.; Tainio, M.; Hérick de Sá, T.; Smith, A.D.; Sharp, S.J.; Edwards, P.; Woodcock, J.; Brage, S.; Wijndaele, K. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: A systematic review and dose response meta-analysis. Eur. J. Epidemiol. 2018, 33, 811–829. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ekelund, U.; Brown, W.J.; Steene-Johannessen, J.; Fagerland, M.W.; Owen, N.; Powell, K.E.; Bauman, A.E.; Lee, I.-M. Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850,060 participants. Br. J. Sports Med. 2019, 53, 886–894. [Google Scholar] [CrossRef] [PubMed]
- Duran, A.T.; Romero, E.; Diaz, K.M. Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease? Curr. Cardiol. Rep. 2022, 24, 393–403. [Google Scholar] [CrossRef]
- Brocklebank, L.A.; Falconer, C.L.; Page, A.S.; Perry, R.; Cooper, A.R. Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review. Prev. Med. 2015, 76, 92–102. [Google Scholar] [CrossRef] [Green Version]
- Chau, J.Y.; Grunseit, A.; Midthjell, K.; Holmen, J.; Holmen, T.L.; Bauman, A.E.; van der Ploeg, H.P. Cross-sectional associations of total sitting and leisure screen time with cardiometabolic risk in adults. Results from the HUNT Study, Norway. J. Sci. Med. Sport 2014, 17, 78–84. [Google Scholar] [CrossRef]
- Thorp, A.A.; Healy, G.N.; Owen, N.; Salmon, J.; Ball, K.; Shaw, J.E.; Zimmet, P.Z.; Dunstan, D.W. Deleterious associations of sitting time and television viewing time with cardiometabolic risk biomarkers: Australian Diabetes, Obesity and Lifestyle (AusDiab) study 2004–2005. Diabetes Care 2010, 33, 327–334. [Google Scholar] [CrossRef] [Green Version]
- Chastin, S.; Culhane, B.; Dall, P. Comparison of self-reported measure of sitting time (IPAQ) with objective measurement (activPAL). Physiol. Meas. 2014, 35, 2319. [Google Scholar] [CrossRef] [Green Version]
- Bauman, A.; Ainsworth, B.E.; Bull, F.; Craig, C.L.; Hagströmer, M.; Sallis, J.F.; Pratt, M.; Sjöström, M. Progress and Pitfalls in the Use of the International Physical Activity Questionnaire (IPAQ) for Adult Physical Activity Surveillance. J. Phys. Act. Health 2009, 6, S5–S8. [Google Scholar] [CrossRef] [Green Version]
- Chastin, S.F.; Dontje, M.L.; Skelton, D.A.; Čukić, I.; Shaw, R.J.; Gill, J.M.R.; Greig, C.A.; Gale, C.R.; Deary, I.J.; Der, J.; et al. Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL). Int. J. Behav. Nutr. Phys. Act. 2018, 15, 1–12. [Google Scholar] [CrossRef]
- Celis-Morales, C.A.; Perez-Bravo, F.; Ibañez, L.; Salas, C.; Bailey, M.E.S.; Gill, J.M.R. Objective vs. self-reported physical activity and sedentary time: Effects of measurement method on relationships with risk biomarkers. PLoS ONE 2012, 7, e36345. [Google Scholar] [CrossRef] [PubMed]
- Healy, G.N.; Wijndaele, K.; Dunstan, D.W.; Shaw, J.E.; Salmon, J.; Zimmet, P.Z.; Owen, N. Objectively measured sedentary time, physical activity, and metabolic risk: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 2008, 31, 369–371. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Henson, J.; Yates, T.; Biddle, S.J.H.; Edwardson, C.L.; Khunti, K.; Wilmot, E.G.; Gray, L.J.; Gorely, T.; Nimmo, M.A.; Davies, M.J. Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health. Diabetologia 2013, 56, 1012–1020. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Healy, G.N.; Matthews, C.E.; Dunstan, D.W.; Winkler, E.A.H.; Owen, N. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06. Eur. Heart J. 2011, 32, 590–597. [Google Scholar] [CrossRef] [Green Version]
- Maher, C.; Olds, T.; Mire, E.; Katzmarzyk, P.T. Reconsidering the sedentary behaviour paradigm. PLoS ONE 2014, 9, e86403. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Buman, M.P.; Winkler, E.A.; Kurka, J.M.; Hekler, E.B.; Baldwin, C.M.; Owen, N.; Ainsworth, B.E.; Healy, G.N.; Gardiner, P.A. Reallocating time to sleep, sedentary behaviors, or active behaviors: Associations with cardiovascular disease risk biomarkers, NHANES 2005–2006. Am. J. Epidemiol 2014, 179, 323–334. [Google Scholar] [CrossRef]
- Farrahi, V.; Kangas, M.; Kiviniemi, A.; Puukka, K.; Korpelainen, R.; Jämsä, T. Accumulation patterns of sedentary time and breaks and their association with cardiometabolic health markers in adults. Scand. J. Med. Sci. Sports 2021, 31, 1489–1507. [Google Scholar] [CrossRef]
- Healy, G.N.; Dunstan, D.W.; Salmon, J.; Cerin, E.; Shaw, J.E.; Zimmet, P.Z.; Owen, N. Breaks in sedentary time: Beneficial associations with metabolic risk. Diabetes Care 2008, 31, 661–666. [Google Scholar] [CrossRef] [Green Version]
- Huang, B.H.; Hamer, M.; Chastin, S.; Pearson, N.; Koster, A.; Stamatakis, E. Cross-sectional associations of device-measured sedentary behaviour and physical activity with cardio-metabolic health in the 1970 British Cohort Study. Diabet. Med. 2021, 38, e14392. [Google Scholar] [CrossRef]
- Cooper, A.R.; Sebire, S.; Montgomery, A.A.; Peters, T.J.; Sharp, D.J.; Jackson, N.; Fitzsimons, K.; Dayan, C.M.; Andrews, R.C. Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes. Diabetologia 2012, 55, 589–599. [Google Scholar] [CrossRef]
- Chastin, S.F.M.; Egerton, T.; Leask, C.; Stamatakis, E. Meta-analysis of the relationship between breaks in sedentary behavior and cardiometabolic health. Obesity 2015, 23, 1800–1810. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Morris, J.N.; Crawford, M.D. Coronary heart-disease and physical activity of work. Lancet 1953, 262, 1111–1120. [Google Scholar] [CrossRef] [PubMed]
- Dunstan, D.W.; Barr, E.L.M.; Healy, G.N.; Salmon, J.; Shaw, J.E.; Balkau, B.; Magliano, D.J.; Cameron, A.J.; Zimmet, P.Z.; Owen, N. Television viewing time and mortality: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Circulation 2010, 121, 384–391. [Google Scholar] [CrossRef] [Green Version]
- Wijndaele, K.; Brage, S.; Besson, H.; Khaw, K.-T.; Sharp, S.J.; Luben, R.; Bhaniani, A.; Wareham, N.J.; Ekelund, U. Television viewing and incident cardiovascular disease: Prospective associations and mediation analysis in the EPIC Norfolk Study. PLoS ONE 2011, 6, e20058. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Stamatakis, E.; Hamer, M.; Dunstan, D.W. Screen-based entertainment time, all-cause mortality, and cardiovascular events: Population-based study with ongoing mortality and hospital events follow-up. J. Am. Coll. Cardiol. 2011, 57, 292–299. [Google Scholar] [CrossRef]
- Syed, I.A.A.; Khan, W.A. Glycated haemoglobin—A marker and predictor of cardiovascular disease. JPMA-J. Pak. Med. Assoc. 2011, 61, 690. [Google Scholar]
- Miller, M. Dyslipidemia and cardiovascular risk: The importance of early prevention. QJM Int. J. Med. 2009, 102, 657–667. [Google Scholar] [CrossRef] [Green Version]
- O’Keefe, J.H.; Bell, D.S.H. Postprandial Hyperglycemia/Hyperlipidemia (Postprandial Dysmetabolism) Is a Cardiovascular Risk Factor. Am. J. Cardiol. 2007, 100, 899–904. [Google Scholar] [CrossRef]
- Champion, R.B.; Smith, L.R.; Smith, J.; Hirlav, B.; Maylor, B.D.; White, S.L.; Bailey, D.P. Reducing prolonged sedentary time using a treadmill desk acutely improves cardiometabolic risk markers in male and female adults. J. Sports Sci. 2018, 36, 2484–2491. [Google Scholar] [CrossRef] [Green Version]
- Pulsford, R.M.; Blackwell, J.; Hillsdon, M.; Kos, K. Intermittent walking, but not standing, improves postprandial insulin and glucose relative to sustained sitting: A randomised cross-over study in inactive middle-aged men. J. Sci. Med. Sport 2017, 20, 278–283. [Google Scholar] [CrossRef]
- Dunstan, D.W.; Kingwell, B.A.; Larsen, R.; Healy, G.N.; Cerin, E.; Hamilton, M.T.; Shaw, J.E.; Bertovic, D.A.; Zimmet, P.Z.; Salmon, J.; et al. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 2012, 35, 976–983. [Google Scholar] [CrossRef]
- Saunders, T.J.; Atkinson, H.F.; Burr, J.; MacEwen, B.; Skeaff, C.M.; Peddie, M.C. The Acute Metabolic and Vascular Impact of Interrupting Prolonged Sitting: A Systematic Review and Meta-Analysis. Sports Med. 2018, 48, 2347–2366. [Google Scholar] [CrossRef]
- Chrismas, B.C.; Taylor, L.; Cherif, A.; Sayegh, S.; Rizk, N.; El-Gamal, A.; Allenjawi, S.H.; Bailey, D.P. Postprandial insulin and triglyceride concentrations are suppressed in response to breaking up prolonged sitting in Qatari females. Front. Physiol. 2019, 10, 706. [Google Scholar] [CrossRef] [PubMed]
- Peddie, M.C.; Bone, J.L.; Rehrer, N.J.; Skeaff, C.M.; Gray, A.G.; Perry, T.L. Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: A randomized crossover trial. Am. J. Clin. Nutr. 2013, 98, 358–366. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bailey, D.P.; Broom, D.R.; Chrismas, B.C.R.; Taylor, L.; Flynn, E.; Hough, J. Breaking up prolonged sitting time with walking does not affect appetite or gut hormone concentrations but does induce an energy deficit and suppresses postprandial glycaemia in sedentary adults. Appl. Physiol. Nutr. Metab. 2016, 41, 324–331. [Google Scholar] [CrossRef] [Green Version]
- Bailey, D.P.; Locke, C.D. Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not. J. Sci. Med. Sport 2015, 18, 294–298. [Google Scholar] [CrossRef] [PubMed]
- Mul, J.D.; Stanford, K.I.; Hirshman, M.F.; Goodyear, L.J. Exercise and Regulation of Carbohydrate Metabolism. Prog. Mol. Biol. Transl. Sci. 2015, 135, 17–37. [Google Scholar] [PubMed] [Green Version]
- Latouche, C.; Jowett, J.B.M.; Carey, A.L.; Bertovic, D.A.; Owen, N.; Dunstan, D.W.; Kingwell, B.A. Effects of breaking up prolonged sitting on skeletal muscle gene expression. J. Appl. Physiol. (1985) 2013, 114, 453–460. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Maylor, B.D.; Zakrzewski-Fruer, J.K.; Stensel, D.J.; Orton, C.J.; Bailey, D.P. Effects of Frequency and Duration of Interrupting Sitting on Cardiometabolic Risk Markers. Int. J. Sports Med. 2019, 40, 818–824. [Google Scholar] [CrossRef] [Green Version]
- Dempsey, P.C.; Larsen, L.N.; Sethi, P.; Sacre, J.W.; Straznicky, N.E.; Cohen, N.D.; Cerin, E.; Lambert, G.W.; Owen, N.; Kingwell, B.A.; et al. Benefits for type 2 diabetes of interrupting prolonged sitting with brief bouts of light walking or simple resistance activities. Diabetes Care 2016, 39, 964–972. [Google Scholar] [CrossRef] [Green Version]
- Charlett, O.P.; Morari, V.; Bailey, D.P. Impaired postprandial glucose and no improvement in other cardiometabolic responses or cognitive function by breaking up sitting with bodyweight resistance exercises: A randomised crossover trial. J. Sports Sci. 2021, 39, 792–800. [Google Scholar] [CrossRef] [PubMed]
- Binzen, C.A.; Swan, P.D.; Manore, M.M. Postexercise oxygen consumption and substrate use after resistance exercise in women. Med. Sci. Sports Exerc. 2001, 33, 932–938. [Google Scholar] [CrossRef] [PubMed]
- Yates, T.; Edwardson, C.L.; Celis-Morales, C.; Biddle, S.J.H.; Bodicoat, D.; Davies, M.J.; Esliger, D.; Henson, J.; Kazi, A.; Khunti, K.; et al. Metabolic effects of breaking prolonged sitting with standing or light walking in older South Asians and white Europeans: A randomized acute study. J. Gerontol. Ser. A 2020, 75, 139–146. [Google Scholar] [CrossRef] [Green Version]
- Benatti, F.B.; Larsen, S.A.; Kofoed, K.; Nielsen, S.T.; Harder-Lauridsen, N.M.; Lyngbæk, M.P.; Eriksen, D.; Karstoft, K.; Krogh-Madsen, R.; Pedersen, B.K.; et al. Intermittent Standing but not a Moderate Exercise Bout Reduces Postprandial Glycemia. Med. Sci. Sports Exerc. 2017, 49, 2305–2314. [Google Scholar] [CrossRef] [PubMed]
- Miyashita, M.; Park, J.-H.; Takahashi, M.; Suzuki, K.; Stensel, D.; Nakamura, Y. Postprandial lipaemia: Effects of sitting, standing and walking in healthy normolipidaemic humans. Int. J. Sports Med. 2013, 34, 21–27. [Google Scholar] [CrossRef]
- Buffey, A.J.; Herring, M.P.; Langley, C.K.; Donnelly, A.E.; Carson, B.P. The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis. Sports Med. 2022, 52, 1765–1787. [Google Scholar] [CrossRef]
- Crespo, N.C.; Mullane, S.L.; Zeigler, Z.S.; Buman, M.P.; Gaesser, G.A. Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose. Med. Sci. Sports Exerc. 2016, 48, 2503–2511. [Google Scholar] [CrossRef]
- Thorp, A.A.; Kingwell, B.A.; Sethi, P.; Hammond, L.; Owen, N.; Dunstan, D.W. Alternating bouts of sitting and standing attenuate postprandial glucose responses. Med. Sci. Sports Exerc. 2014, 46, 2053–2061. [Google Scholar] [CrossRef] [Green Version]
- Henson, J.; Davies, M.J.; Bodicoat, D.H.; Edwardson, E.C.; Gill, J.M.R.; Stensel, D.J.; Tolfrey, K.; Dunstan, D.W.; Khunti, K.; Yates, T. Breaking Up Prolonged Sitting with Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study. Diabetes Care 2016, 39, 130–138. [Google Scholar] [CrossRef] [Green Version]
- Homer, A.R.; Fenemor, S.P.; Perry, T.L.; Rehrer, N.J.; Cameron, C.M.; Skeaff, C.M.; Peddie, M.C. Regular activity breaks combined with physical activity improve postprandial plasma triglyceride, nonesterified fatty acid, and insulin responses in healthy, normal weight adults: A randomized crossover trial. J. Clin. Lipidol. 2017, 11, 1268–1279.e1. [Google Scholar] [CrossRef] [PubMed]
- Miyashita, M.; Burns, S.F.; Stensel, D.J. Accumulating short bouts of brisk walking reduces postprandial plasma triacylglycerol concentrations and resting blood pressure in healthy young men. Am. J. Clin. Nutr. 2008, 88, 1225–1231. [Google Scholar] [PubMed]
- Miyashita, M. Effects of continuous versus accumulated activity patterns on postprandial triacylglycerol concentrations in obese men. Int. J. Obes. 2008, 32, 1271–1278. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hamilton, M.T.; Hamilton, D.G.; Zderic, T.W. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 2007, 56, 2655–2667. [Google Scholar] [CrossRef] [Green Version]
- Greiwe, J.S.; Holloszy, J.O.; Semenkovich, C.F. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. J. Appl. Physiol. (1985) 2000, 89, 176–181. [Google Scholar] [CrossRef] [Green Version]
- Altenburg, T.M.; Rotteveel, J.; Dunstan, D.W.; Salmon, J.; Chinapaw, M.J.M. The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults. J. Appl. Physiol. (1985) 2013, 115, 1751–1756. [Google Scholar] [CrossRef]
- Miyashita, M.; Edamoto, K.; Kidokoro, T.; Yanaoka, T.; Kashiwabara, K.; Takahashi, M.; Burns, S. Interrupting sitting time with regular walks attenuates postprandial triglycerides. Int. J. Sports Med. 2016, 37, 97–103. [Google Scholar] [CrossRef]
- Kashiwabara, K.; Kidokoro, T.; Yanaoka, T.; Burns, S.F.; Stensel, S.; Miyashita, M. Different patterns of walking and postprandial triglycerides in older women. Med. Sci. Sports Exerc. 2018, 50, 79. [Google Scholar] [CrossRef] [Green Version]
- Maylor, B.D.; Zakrzewski-Fruer, J.K.; Orton, C.J.; Bailey, D.P. Beneficial postprandial lipaemic effects of interrupting sedentary time with high-intensity physical activity versus a continuous moderate-intensity physical activity bout: A randomised crossover trial. J. Sci. Med. Sport 2018, 21, 1250–1255. [Google Scholar] [CrossRef]
- Bailey, D.P.; Orton, C.J.; Maylor, B.D.; Zakrzewski-Fruer, J.K. Cardiometabolic response to a single high-intensity interval exercise session versus breaking up sedentary time with fragmented high-intensity interval exercise. Int. J. Sports Med. 2019, 40, 165–170. [Google Scholar] [CrossRef]
- Wheeler, M.J.; Dunstan, D.W.; Ellis, K.A.; Cerin, E.; Phillips, S.; Lambert, G.; Naylor, L.H.; Dempsey, P.C.; Kingwell, B.A.; Green, D.J. Effect of morning exercise with or without breaks in prolonged sitting on blood pressure in older overweight/obese adults: Evidence for sex differences. Hypertension 2019, 73, 859–867. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Dempsey, P.C.; Sacre, J.W.; Larsen, R.N.; Straznicky, N.E.; Sethi, P.; Cohen, N.D.; Cerin, E.; Lambert, G.W.; Owen, N.; Kingwell, B.A.; et al. Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes. J. Hypertens. 2016, 34, 2376–2382. [Google Scholar] [CrossRef] [PubMed]
- Zeigler, Z.S.; Mullane, S.L.; Crespo, N.C.; Buman, M.P.; Gaesser, G.A. Effects of standing and light-intensity activity on ambulatory blood pressure. Med. Sci. Sports Exerc. 2016, 48, 175–181. [Google Scholar] [CrossRef] [PubMed]
- Bhammar, D.M.; Sawyer, B.J.; Tucker, W.J.; Gaesser, G.A. Breaks in sitting time: Effects on continuously monitored glucose and blood pressure. Med. Sci. Sports Exerc. 2017, 49, 2119–2130. [Google Scholar] [CrossRef] [PubMed]
- Altenburg, T.M.; Rotteveel, J.; Serné, E.H.; Chinapaw, M.J.M. Standing is not enough: A randomized crossover study on the acute cardiometabolic effects of variations in sitting in healthy young men. J. Sci. Med. Sport 2019, 22, 790–796. [Google Scholar] [CrossRef] [Green Version]
- Paterson, C.; Fryer, S.; Stone, K.; Zieff, G.; Turner, L.; Stoner, L. The effects of acute exposure to prolonged sitting, with and without interruption, on peripheral blood pressure among adults: A systematic review and meta-analysis. Sports Med. 2021, 52, 1369–1383. [Google Scholar] [CrossRef]
- Carter, S.; Hartman, Y.; Holder, S.; Thijssen, D.H.; Hopkins, N.D. Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms. Exerc. Sport Sci. Rev. 2017, 45, 80–86. [Google Scholar] [CrossRef]
- Thosar, S.S.; Bielko, S.L.; Mather, K.J.; Johnston, J.D.; Wallace, J.P. Effect of prolonged sitting and breaks in sitting time on endothelial function. Med. Sci. Sports Exerc. 2015, 47, 843–849. [Google Scholar] [CrossRef] [Green Version]
- Barone Gibbs, B.; Kowalsky, R.J.; Perdomo, S.J.; Taormina, J.M.; Balzer, J.R.; Jakicic, J.M. Effect of alternating standing and sitting on blood pressure and pulse wave velocity during a simulated workday in adults with overweight/obesity. J. Hypertens. 2017, 35, 2411–2418. [Google Scholar] [CrossRef]
- Fernandes, D.C.; Araujo, T.L.S.; Laurindo, F.L.M.; Tanaka, L. Chapter 7—Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis. In Endothelium and Cardiovascular Diseases; Da Luz, P.L., Ed.; Academic Press: Cambridge, MA, USA, 2018; pp. 85–95. [Google Scholar]
- Duvivier, B.M.; Schaper, N.C.; Bremers, M.A.; van Crombrugge, G.; Menheere, P.P.C.A.; Kars, M.; Savelberg, H.H.C.M. Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous exercise (cycling) in sedentary subjects when energy expenditure is comparable. PLoS ONE 2013, 8, e55542. [Google Scholar] [CrossRef]
- Duvivier, B.M.; Schaper, N.C.; Koster, A.; van Kan, L.; Peters, H.P.F.; Adam, J.J.; Giesbrecht, T.; Kornips, E.; Hulsbosch, M.; Willems, P.; et al. Benefits of substituting sitting with standing and walking in free-living conditions for cardiometabolic risk markers, cognition and mood in overweight adults. Front. Physiol. 2017, 8, 353. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Duvivier, B.M.; Schaper, N.C.; Hesselink, M.K.C.; van Kan, L.; Stienen, N.; Winkens, B.; Koster, A.; Savelberg, H.H.C.M. Breaking sitting with light activities vs structured exercise: A randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes. Diabetologia 2017, 60, 490–498. [Google Scholar] [CrossRef] [PubMed]
- Bailey, D.P.; Stringer, C.A.; Maylor, B.D.; Zakrzewski-Fruer, J.K. Lower amounts of daily and prolonged sitting do not lower free-living continuously monitored glucose concentrations in overweight and obese adults: A randomised crossover study. Nutrients 2022, 14, 605. [Google Scholar] [CrossRef] [PubMed]
- Smith, J.A.; Savikj, M.; Sethi, P.; Platt, S.; Gabriel, B.M.; Hawley, J.A.; Dunstan, D.; Krook, A.; Zierath, J.R.; Näslund, E. Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity. Am. J. Physiol. Endocrinol. Metab. 2021, 321, E203–E216. [Google Scholar] [CrossRef] [PubMed]
- Blankenship, J.M.; Chipkin, S.R.; Freedson, P.S.; Staudenmayer, J.; Lyden, K.; Braun, B. Managing free-living hyperglycemia with exercise or interrupted sitting in type 2 diabetes. J. Appl. Physiol. (1985) 2019, 126, 616–625. [Google Scholar] [CrossRef]
- Hadgraft, N.T.; Healy, G.N.; Owen, N.; Winkler, E.A.H.; Lynch, B.M.; Sethi, P.; Eakin, E.G.; Moodie, M.; LaMontagne, A.D.; Wiesner, G. Office workers’ objectively assessed total and prolonged sitting time: Individual-level correlates and worksite variations. Prev. Med. Rep. 2016, 4, 184–191. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Maylor, B.D.; Edwardson, C.L.; Zakrzewski-Fruer, J.K.; Champion, R.B.; Bailey, D.P.; Bedford, U.K. Efficacy of a multi-component cluster randomised controlled trial to reduce workplace sedentary behaviour in office workers. J. Occup. Environ. Med. 2018, 60, 787–795. [Google Scholar] [CrossRef] [Green Version]
- Mainsbridge, C.P.; Cooley, P.D.; Fraser, S.P.; Pedersen, S.J. The effect of an e-health intervention designed to reduce prolonged occupational sitting on mean arterial pressure. J. Occup. Environ. Med. 2014, 56, 1189–1194. [Google Scholar] [CrossRef] [Green Version]
- Brierley, M.L.; Chater, A.M.; Smith, L.R.; Bailey, D.P. The Effectiveness of Sedentary Behaviour Reduction Workplace Interventions on Cardiometabolic Risk Markers: A Systematic Review. Sports Med. 2019, 49, 1739–1767. [Google Scholar] [CrossRef]
- Healy, G.N.; Eakin, E.G.; Owen, N.; Lamontagne, A.D.; Moodie, M.; Winkler, E.A.H.; Fjeldsoe, B.S.; Wiesner, G.; Willenberg, L.; Dunstan, D.W. A Cluster Randomized Controlled Trial to Reduce Office Workers’ Sitting Time: Effect on Activity Outcomes. Med. Sci. Sports Exerc. 2016, 48, 1787–1797. [Google Scholar] [CrossRef]
- Healy, G.N.; Winkler, E.A.H.; Eakin, E.G.; Owen, N.; Lamontagne, A.D.; Moodie, M.; Dunstan, D.W. A Cluster RCT to Reduce Workers’ Sitting Time: Impact on Cardiometabolic Biomarkers. Med. Sci. Sports Exerc. 2017, 49, 2032–2039. [Google Scholar] [CrossRef] [PubMed]
- Akksilp, K.; Koh, J.J.E.; Tan, V.; Tong, E.H.; Budtarad, N.; Xueying, G.; Dieterich, A.V.; Tai, B.C.; Müller, A.M.; Isaranuwatchai, W.; et al. The physical activity at work (PAW) study: A cluster randomised trial of a multicomponent short-break intervention to reduce sitting time and increase physical activity among office workers in Thailand. Lancet Reg. Health—Southeast Asia 2022, 100086. [Google Scholar] [CrossRef]
- Bailey, D.P.; Mugridge, L.H.; Dong, F.; Zhang, X.; Chater, A.M. Randomised Controlled Feasibility Study of the MyHealthAvatar-Diabetes Smartphone App for Reducing Prolonged Sitting Time in Type 2 Diabetes Mellitus. Int. J. Environ. Res. Public Health 2020, 17, 4414. [Google Scholar] [CrossRef] [PubMed]
- Brakenridge, C.J.; Gardiner, P.A.; Grigg, R.V.; Winkler, E.A.H.; Fjeldsoe, B.S.; Schaumberg, M.A.; Owen, N.; Eakin, E.G.; Biddle, S.J.H.; Moodie, M.; et al. Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ’OPTIMISE your health’ trial protocol. BMC Public Health 2022, 22, 929. [Google Scholar] [CrossRef] [PubMed]
- Syrjälä, M.B.; Bennet, L.; Dempsey, P.C.; Fharm, E.; Hellgren, M.; Jansson, S.; Nilsson, S.; Nordendahl, M.; Rolandsson, O.; Rådholm, K.; et al. Health effects of reduced occupational sedentary behaviour in type 2 diabetes using a mobile health intervention: A study protocol for a 12-month randomized controlled trial-the ROSEBUD study. Trials 2022, 23, 607. [Google Scholar] [CrossRef]
- Bailey, D.P.; Edwardson, C.L.; Pappas, Y.; Dong, F.; Hewson, D.J.; Biddle, S.J.H.; Brierley, M.L.; Chater, A.M. A randomised-controlled feasibility study of the REgulate your SItting Time (RESIT) intervention for reducing sitting time in individuals with type 2 diabetes: Study protocol. Pilot. Feasibility Stud. 2021, 7, 76. [Google Scholar] [CrossRef]
- van Bakel, B.M.A.; Kroesen, S.H.; Günal, A.; Scheepmaker, A.; Aengevaeren, W.R.M.; Willems, F.F.; Wondergem, R.; Pisters, M.F.; Dam, J.; Janssen, A.M.; et al. Sedentary Behaviour Intervention as a Personalised Secondary Prevention Strategy (SIT LESS) for patients with coronary artery disease participating in cardiac rehabilitation: Rationale and design of the SIT LESS randomised clinical trial. BMJ Open Sport Exerc. Med. 2022, 8, e001364. [Google Scholar] [CrossRef]
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Bell, A.C.; Richards, J.; Zakrzewski-Fruer, J.K.; Smith, L.R.; Bailey, D.P. Sedentary Behaviour—A Target for the Prevention and Management of Cardiovascular Disease. Int. J. Environ. Res. Public Health 2023, 20, 532. https://doi.org/10.3390/ijerph20010532
Bell AC, Richards J, Zakrzewski-Fruer JK, Smith LR, Bailey DP. Sedentary Behaviour—A Target for the Prevention and Management of Cardiovascular Disease. International Journal of Environmental Research and Public Health. 2023; 20(1):532. https://doi.org/10.3390/ijerph20010532
Chicago/Turabian StyleBell, Abbie C., Joanna Richards, Julia K. Zakrzewski-Fruer, Lindsey R. Smith, and Daniel P. Bailey. 2023. "Sedentary Behaviour—A Target for the Prevention and Management of Cardiovascular Disease" International Journal of Environmental Research and Public Health 20, no. 1: 532. https://doi.org/10.3390/ijerph20010532