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Medicina
Volume 59
Issue 3
10.3390/medicina59030631
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Case Report
Peer-Review Record

Programmed Death-Ligand 1-Positive Squamous Cell Carcinoma Spontaneously Regressed after Percutaneous Needle Biopsy

Medicina 2023, 59(3), 631; https://doi.org/10.3390/medicina59030631
by Masayuki Sasahara 1,2,*, Hiroki Takahashi 1, Takashi Ohchi 1, Naohiro Nomura 1, Kentaro Kodama 2, Kimiyuki Ikeda 2, Hirotaka Nishikiori 2, Kenzo Okamoto 3 and Hirofumi Chiba 2
Reviewer 1:
Angelo Carretta
Reviewer 2:
Goohyeon Hong
Medicina 2023, 59(3), 631; https://doi.org/10.3390/medicina59030631
Submission received: 15 February 2023 / Revised: 19 March 2023 / Accepted: 20 March 2023 / Published: 22 March 2023
(This article belongs to the Section Pulmonary)

Round 1

Reviewer 1 Report

In this Case report the Authors describe a spontaneous regression of a squamous cell lung cancer with PD-L1 expression after CT-guided percutaneous needle biopsy. This event has been reported only in few previous reports, most of which without an analysis of PD-L1 expression, and the manuscript could therefore be of interest. Th Authors should address some minor points:

It should be reported if any steroid therapy was administered along with the antimicrobial therapy

Since, as the Authors report, previous reports have shown in some cases re-growth of the lesion after temporary regression, a follow-up longer than 20 months is required to draw definite conclusions.

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This is a rare and interesting case report of spontaneously regressed after percutaneous needle biopsy of programmed death-ligand 1-positive squamous cell carcinoma in the lung. This case report would be may provide some useful information on the spontaneously regressed of NSCLC (squamous cell carcinoma). I have a few minor comments.

 

1. Has the patient had a history of malignancy? Please describe in detail.

 

2. Page 1, line 41-42. “And no 41 obvious metastasis to other organs or lymph nodes was observed.”

: Did you perform PET/CT in this patient for nodule which located in the S4 of the left lung? If you performed PET/CT, please add the image of PET/CT.

 

3. Authors presume that the mechanical stimulation induced by biopsy suppressed the interaction of PD-1 and PD-L1 via an immunological mechanism that mimics immune checkpoint inhibitors, resulting in the shrinkage of tumor.

: How do you think about the shrinkage of tumor mass without biopsy in other case reports? What kind of immune response can explain this case?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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