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Curr. Issues Mol. Biol., Volume 5, Issue 3 (July 2003) – 3 articles

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699 KiB  
Review
Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends
by Lynne Cassimeris and Robert V. Skibbens
Curr. Issues Mol. Biol. 2003, 5(3), 99-112; https://doi.org/10.21775/cimb.005.099 - 01 Jul 2003
Viewed by 309
Abstract
Chromosome segregration and cell division requires the regulated assembly of the mitotic spindle apparatus. This mitotic spindle is composed of condensed chromosomes attached to a dynamic array of microtubules. The microtubule array is nucleated by centrosomes and organized by associated structural and motor [...] Read more.
Chromosome segregration and cell division requires the regulated assembly of the mitotic spindle apparatus. This mitotic spindle is composed of condensed chromosomes attached to a dynamic array of microtubules. The microtubule array is nucleated by centrosomes and organized by associated structural and motor proteins. Mechanical linkages between sister chromatids and microtubules are critical for spindle assembly and chromosome segregation. Defects in either chromosome or centrosome segregation can lead to aneuploidy and are correlated with cancer progression. In this review, we discuss current models of how centrosomes and chromosomes organize the spindle for their equal distribution to each daughter cell. Full article
697 KiB  
Review
Impact of Transgenic Technologies on Functional Genomics
by Cooduvalli S. Shashikant and Frank H. Ruddle
Curr. Issues Mol. Biol. 2003, 5(3), 75-98; https://doi.org/10.21775/cimb.005.075 - 01 Jul 2003
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Abstract
Gene transfer technologies in mammals are the focus of renewed interest owing to the recent emphasis on analyzing gene function in the postgenomic era. Three important developments in this area include transgenics, gene targeting and nuclear transfer or animal cloning. These technological innovations [...] Read more.
Gene transfer technologies in mammals are the focus of renewed interest owing to the recent emphasis on analyzing gene function in the postgenomic era. Three important developments in this area include transgenics, gene targeting and nuclear transfer or animal cloning. These technological innovations have enhanced our ability to analyze gene function at the level of the whole organism and have provided the means to modify gene expression. This review discusses the origins and current status of transgenic technologies. Various applications and technologies including chromosome engineering, stem cells, gene traps and modification of livestock are presented. The impact of mouse technologies and genomics on functional analyses is also discussed. Full article
617 KiB  
Review
Genomes and Genome Projects of Protozoan Parasites
by Klaus Ersfeld
Curr. Issues Mol. Biol. 2003, 5(3), 61-74; https://doi.org/10.21775/cimb.005.061 - 01 Jul 2003
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Abstract
Protozoan parasites are causing some of the most devastating diseases world-wide. It has now been recognised that a major effort is needed to be able to control or eliminate these diseases. Genome projects for the most important protozoan parasites have been initiated in [...] Read more.
Protozoan parasites are causing some of the most devastating diseases world-wide. It has now been recognised that a major effort is needed to be able to control or eliminate these diseases. Genome projects for the most important protozoan parasites have been initiated in the hope that the read-out of these projects will help to understand the biology of the parasites and identify new targets for urgently needed drugs. Here, I will review the current status of protozoan parasite genome projects, present findings obtained as a result of the availability of genomic data and discuss the potential impact of genome information on disease control. Full article
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