Topic Editors

Department of Ecological and Biological Sciences (DEB), University of Tuscia, 00110 Viterbo, Italy
Department of Pediatrics, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan

Autism: Molecular Bases, Diagnosis and Therapies, 2nd Volume

Abstract submission deadline
31 March 2025
Manuscript submission deadline
31 May 2025
Viewed by
146

Topic Information

Dear Colleagues,

The causes of autism are still unknown today. More recent studies suggest that autism spectrum disorders may occur following the birth of abnormal neurons (neurobiological causes) that fail to create correct connections with the other nerve cells of the brain, to the point of causing incorrect the functioning of the entire organ. Neuronal networks are formed, above all, during the foetal development phase, allowing one to hypothesize that the cause of this disorder is due to a combination of genetic factors, congenital alterations, and environmental risk factors. There is evidence of familiarity, but also of individuals with autism as carriers of certain genetic diseases (Rett syndrome, Angelman syndrome, etc.), as well as learning disabilities such as dyslexia and dyscalculia, ADHD, Tourette's syndrome, etc. It is therefore necessary to gather more information on the possible causes of the onset of autism in order to better understand it, intervene, and propose targeted therapies. Unfortunately, the diagnosis is often made around the age of 6, when children begin to experience the first difficulties of the condition, with extremely variable symptoms both in extent and in severity. Diagnosis must not be based on psychological tests only, but also on genetic, biochemical and microbiological analysis. A list of possible biomarkers in the urine and blood to allow an early (from the first years of life) and accurate diagnosis is of fundamental importance in order to define the most appropriate therapy. Therapy must be multimodal, i.e., psychological but also pharmacological, especially when some symptoms are particularly debilitating, or present with particular associated pathologies. The outcome of this Special Issue will represent a further step in understanding the molecular mechanisms underlying autism spectrum disorder in order to achieve early diagnosis and provide researchers and clinicians with the most up-to-date information on possible biomarkers to help them understand how to implement therapeutic strategies for patients.

Prof. Dr. Lello Zolla
Prof. Dr. Kunio Yui
Topic Editors

Keywords

  • genetic causes of autism
  • genetic mutations
  • altered metabolism
  • environmental factors
  • gene-environment interactions
  • risk factors
  • microbiota-gut-brain-axis
  • diagnostic marker
  • therapeutic marker
  • metabolomics
  • proteomics
  • metagenomics
  • interactomics
  • neurotransmitter
  • molecular neuroscience

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
4.7 3.7 2013 15.4 Days CHF 2600 Submit
Brain Sciences
brainsci
3.3 3.9 2011 15.6 Days CHF 2200 Submit
Current Issues in Molecular Biology
cimb
3.1 2.4 1999 13.5 Days CHF 2200 Submit
Diagnostics
diagnostics
3.6 3.6 2011 20.7 Days CHF 2600 Submit
International Journal of Molecular Sciences
ijms
5.6 7.8 2000 16.3 Days CHF 2900 Submit
International Journal of Translational Medicine
ijtm
- - 2021 14.2 Days CHF 1000 Submit

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