The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment
The tumor microenvironment (TME) is a complex and dynamic ecosystem that influences tumor progression, invasion, metastasis, and treatment response. It is composed of cancer cells, stromal cells, immune cells, and various components of the extracellular matrix and recent research indicates that these components communicate with each other via extracellular vesicles (EVs). EVs are small membrane-bound vesicles released by almost all cells, including cancer cells, and are known to carry various bioactive molecules, such as proteins, nucleic acids, and lipids. This topic is dedicated to the emerging understanding of how EVs contribute to the modulation of the TME. Hereby, we focus on a variety of EV-related aspects, including, but not limited to, EVs as modulators of intercellular communication, the role of EVs in remodeling the extracellular matrix, the immunomodulatory effects of EVs, and EVs as biomarkers and therapeutic targets. We hope that this topic will provide further insights into the complex role of EVs in modulating the TME and will accelerate the development of novel EV-based therapeutic strategies.
Dr. Nils Ludwig
Dr. Miroslaw J Szczepanski
- extracellular vesicles
- tumor microenvironment
- intercellular communication
|Journal Name||Impact Factor||CiteScore||Launched Year||First Decision (median)||APC|
|5.5||8.3||2011||19.2 Days||CHF 2700||Submit|
Current Issues in Molecular Biologycimb
|3.1||2.4||1999||16.5 Days||CHF 2000||Submit|
|2.5||6.4||1930||21.7 Days||CHF 1000||Submit|
|5.2||7.4||2009||18.2 Days||CHF 2900||Submit|
|2.6||2.6||1994||18.4 Days||CHF 2200||Submit|
|6.0||9.0||2012||18.8 Days||CHF 2700||Submit|
Preprints is a platform dedicated to making early versions of research outputs permanently available and citable. MDPI journals allow posting on preprint servers such as Preprints.org prior to publication. For more details about reprints, please visit https://www.preprints.org.