New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications

Topic Information

Dear Colleagues,

Bioactive compounds are a group of components present in small amounts in plants and foods (such as fruits, vegetables, nuts, or oils) and induce activities in the human body that can promote health benefits. These bioactive compounds can be extracted from plants or other biomass products. Essential oils are a large group of bioactive compounds synthesized by plants with different applications. The bioactivity of essential oils can change depending on their origin and composition. Due to their properties, bioactive compounds are commonly used to functionalize and manufacture several products, such as pharmaceutic, cosmetics, and agriculture or food. Currently, conventional methods (e.g., hydrodistillation or using organic solvents) are used to perform the extraction of these bioactive compounds. However, hydrodistillation needs high times and temperature, which can promote chemical changes and negatively impact thermosensitive compounds. Soxhlet extraction uses toxic solvents and has long extraction times, causing thermal degradation of the extract. Thus, there is an increasing interest in nonconventional methods for extracting natural ingredients, such as supercritical fluid extraction, microwave hydrodiffusion and gravity, or using ionic liquids, which intend to increase the selectivity and preserve the substances of interest. The biovalorization of natural products using green extraction methodologies obtained from biomass can have a positive impact on health and the environment, and numerous applications are currently being studied and reported. In this context, this Topic, entitled “New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications", intends to collect studies and technologies on the extraction and refining of bioactive compounds using green and sustainable methodologies, as well as on novel applications of these compounds. We look forward to receiving your work. 

Dr. Isabel Maria Duque Martins
Dr. Madalena M. Dias
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Analytica analytica	-	-	2020	15.6 Days	CHF 1000	Submit
Foods foods	5.2	5.8	2012	13.1 Days	CHF 2900	Submit
Molecules molecules	4.6	6.7	1996	14.6 Days	CHF 2700	Submit
Processes processes	3.5	4.7	2013	13.7 Days	CHF 2400	Submit
Separations separations	2.6	2.5	2014	13.6 Days	CHF 2600	Submit

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Published Papers (3 papers)

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All Analytica Foods Molecules Processes Separations

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Supplementary material:
Supplementary File 1 (ZIP, 344 KiB)

15 pages, 1439 KiB  

Open AccessArticle

Supercritical CO₂ Extraction of Fatty Acids, Phytosterols, and Volatiles from Myrtle (Myrtus communis L.) Fruit

by Daniela Cvitković, Iva Škarica, Verica Dragović-Uzelac and Sandra Balbino

Molecules 2024, 29(8), 1755; https://doi.org/10.3390/molecules29081755 - 12 Apr 2024

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Abstract

Background: Myrtle (Myrtus communis L.) is a coastal Mediterranean aromatic medicinal plant rich in essential oil components, flavonoids, and phenolic acids. Studies highlight the potential health benefits of myrtle bioactive compounds with antioxidant and antiproliferative properties. Since limited research exists on myrtle [...] Read more.

Background: Myrtle (Myrtus communis L.) is a coastal Mediterranean aromatic medicinal plant rich in essential oil components, flavonoids, and phenolic acids. Studies highlight the potential health benefits of myrtle bioactive compounds with antioxidant and antiproliferative properties. Since limited research exists on myrtle fruit’s lipid fraction, the aim of this study was to apply supercritical CO₂ extraction to obtain bioactive compounds from myrtle berries focusing on the fatty acids, sterols, and essential oils. Methods: The optimization of the supercritical CO₂ extraction of myrtle fruit using CO₂ as solvent was carried out using the response surface methodology with Box–Behnken experimental design. The following conditions were tested: temperature (40, 50, and 60 °C), pressure (200, 300, and 400 bar), and flow rate (20, 30, and 40 g min⁻¹) on the yield of lipid extract as well as on the yield of fatty acids, phytosterols, and volatiles present in the extract and constituting its bioactive potential. Results: In the extracts examined, 36 fatty acids, 7 phytosterols, and 13 volatiles were identified. The average yield of the extract was 5.20%, the most abundant identified fatty acid was essential cis-linolenic acid (76.83%), almost 90% of the total phytosterols were β-sitosterol (12,465 mg kg⁻¹), while myrtenyl acetate (4297 mg kg⁻¹) was the most represented volatile compound. The optimal process conditions obtained allow the formulation of extracts with specific compositions. Full article

(This article belongs to the Topic New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications)

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11 pages, 283 KiB  

Open AccessArticle

Analysis of Essential Oil of Salix babylonica Collected in Vietnam: Phytochemical Components and Antibacterial and Anticancer Activity

by Phu Hiep Hoang, Thien Hien Tran and Van Khang Pham

Processes 2024, 12(1), 33; https://doi.org/10.3390/pr12010033 - 22 Dec 2023

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Abstract

This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds [...] Read more.

This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds were identified in essential oils of the leaves and bark, among which many chemical compositions were identified for the first time in this plant. Salix babylonica essential oils demonstrated antibacterial activities against Gram-negative strains such as Pseudomonas aeruginosa (PA) and Escherichia coli and Gram-positive strains such as Staphylococcus aureus (SA), and demonstrated anti-cancer activities against three cancer cell lines (HepG2, MCF-7 cell, and A549). The evaluation of the ability to inhibit three strains of microorganisms and inhibit the growth of three cancer cell lines was first conducted using essential oils extracted from the plant species S. babylonica collected in Asia, which will be the basis for using essential oils of this plant in medicine. Full article

(This article belongs to the Topic New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications)

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Supplementary material:
Supplementary File 1 (ZIP, 195 KiB)

19 pages, 12001 KiB  

Open AccessArticle

Moringa oleifera L. Screening: SFE-CO₂ Optimisation and Chemical Composition of Seed, Leaf, and Root Extracts as Potential Cosmetic Ingredients

by Júlia C. Kessler, Yaidelin A. Manrique, Isabel M. Martins, Alírio E. Rodrigues, Maria Filomena Barreiro and Madalena M. Dias

Separations 2023, 10(3), 210; https://doi.org/10.3390/separations10030210 - 17 Mar 2023

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Abstract

Moringa oleifera L. tree (Mo) has emerged as a rich alternative source of bioactive compounds to design cosmetic formulations. Supercritical carbon dioxide fluid extraction (SFE-CO₂) was successfully applied on the screening of Mo seed, leaf, and root extracts. The extraction yield [...] Read more.

Moringa oleifera L. tree (Mo) has emerged as a rich alternative source of bioactive compounds to design cosmetic formulations. Supercritical carbon dioxide fluid extraction (SFE-CO₂) was successfully applied on the screening of Mo seed, leaf, and root extracts. The extraction yield was evaluated by response surface methodology (RSM), for pressure and temperature ranges of 117–273 bar and 41–60 °C, respectively, using a design of experiments (DOE). The pressure significantly affected the results ($\alpha =0.05$), with the highest extraction efficiency obtained at conditions above 195 bar. The extracts’ composition, evaluated by gas chromatography-mass spectrometer (GC-MS), revealed an increasing correlation between the pressure, total extract solubility, and mass of extract at a constant temperature, due to the higher extraction yield. Seed extracts presented more than 80% of oleic acid in relative composition (8.04 mg_compound∙g_plantpart⁻¹). Leaf extracts performed well for the obtainment of linolenic acid (>20%; 3.10 mg∙g⁻¹), nonacosane (>22%; 0.46 mg∙g⁻¹), and α-tocopherol (>20%; 0.21 mg∙g⁻¹). Mo root resulted in higher relative composition for sterol molecules, despite its very low affinity with CO₂. The most promising bioactive compounds, oleic acid and α-tocopherol, were more abundant when operating at 250 bar at 45 °C and 195 bar at 55 °C, for Mo seed and leaf SFE-CO₂ extracts, respectively. Full article

(This article belongs to the Topic New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications)

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