Topic Editors

Department of Chemical Engineering, Universidade do Porto, Porto, Portugal
Department of Chemical Engineering, Universidade do Porto, Porto, Portugal

New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications

Abstract submission deadline
closed (29 February 2024)
Manuscript submission deadline
30 April 2024
Viewed by
3367

Topic Information

Dear Colleagues,

Bioactive compounds are a group of components present in small amounts in plants and foods (such as fruits, vegetables, nuts, or oils) and induce activities in the human body that can promote health benefits. These bioactive compounds can be extracted from plants or other biomass products. Essential oils are a large group of bioactive compounds synthesized by plants with different applications. The bioactivity of essential oils can change depending on their origin and composition. Due to their properties, bioactive compounds are commonly used to functionalize and manufacture several products, such as pharmaceutic, cosmetics, and agriculture or food. Currently, conventional methods (e.g., hydrodistillation or using organic solvents) are used to perform the extraction of these bioactive compounds. However, hydrodistillation needs high times and temperature, which can promote chemical changes and negatively impact thermosensitive compounds. Soxhlet extraction uses toxic solvents and has long extraction times, causing thermal degradation of the extract. Thus, there is an increasing interest in nonconventional methods for extracting natural ingredients, such as supercritical fluid extraction, microwave hydrodiffusion and gravity, or using ionic liquids, which intend to increase the selectivity and preserve the substances of interest. The biovalorization of natural products using green extraction methodologies obtained from biomass can have a positive impact on health and the environment, and numerous applications are currently being studied and reported. In this context, this Topic, entitled “New Trends on Separation and Extraction of Bioactive Compounds and Respective Applications", intends to collect studies and technologies on the extraction and refining of bioactive compounds using green and sustainable methodologies, as well as on novel applications of these compounds. We look forward to receiving your work. 

Dr. Isabel Maria Duque Martins
Dr. Madalena M. Dias
Topic Editors

Keywords

  • bioactive compounds
  • essential oils
  • bio-waste
  • extraction
  • supercritical fluid extraction using carbon dioxide
  • high-added value products

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Analytica
analytica
- - 2020 15.6 Days CHF 1000 Submit
Foods
foods
5.2 5.8 2012 13.1 Days CHF 2900 Submit
Molecules
molecules
4.6 6.7 1996 14.6 Days CHF 2700 Submit
Processes
processes
3.5 4.7 2013 13.7 Days CHF 2400 Submit
Separations
separations
2.6 2.5 2014 13.6 Days CHF 2600 Submit

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Published Papers (3 papers)

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15 pages, 1439 KiB  
Article
Supercritical CO2 Extraction of Fatty Acids, Phytosterols, and Volatiles from Myrtle (Myrtus communis L.) Fruit
by Daniela Cvitković, Iva Škarica, Verica Dragović-Uzelac and Sandra Balbino
Molecules 2024, 29(8), 1755; https://doi.org/10.3390/molecules29081755 - 12 Apr 2024
Viewed by 303
Abstract
Background: Myrtle (Myrtus communis L.) is a coastal Mediterranean aromatic medicinal plant rich in essential oil components, flavonoids, and phenolic acids. Studies highlight the potential health benefits of myrtle bioactive compounds with antioxidant and antiproliferative properties. Since limited research exists on myrtle [...] Read more.
Background: Myrtle (Myrtus communis L.) is a coastal Mediterranean aromatic medicinal plant rich in essential oil components, flavonoids, and phenolic acids. Studies highlight the potential health benefits of myrtle bioactive compounds with antioxidant and antiproliferative properties. Since limited research exists on myrtle fruit’s lipid fraction, the aim of this study was to apply supercritical CO2 extraction to obtain bioactive compounds from myrtle berries focusing on the fatty acids, sterols, and essential oils. Methods: The optimization of the supercritical CO2 extraction of myrtle fruit using CO2 as solvent was carried out using the response surface methodology with Box–Behnken experimental design. The following conditions were tested: temperature (40, 50, and 60 °C), pressure (200, 300, and 400 bar), and flow rate (20, 30, and 40 g min−1) on the yield of lipid extract as well as on the yield of fatty acids, phytosterols, and volatiles present in the extract and constituting its bioactive potential. Results: In the extracts examined, 36 fatty acids, 7 phytosterols, and 13 volatiles were identified. The average yield of the extract was 5.20%, the most abundant identified fatty acid was essential cis-linolenic acid (76.83%), almost 90% of the total phytosterols were β-sitosterol (12,465 mg kg−1), while myrtenyl acetate (4297 mg kg−1) was the most represented volatile compound. The optimal process conditions obtained allow the formulation of extracts with specific compositions. Full article
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11 pages, 283 KiB  
Article
Analysis of Essential Oil of Salix babylonica Collected in Vietnam: Phytochemical Components and Antibacterial and Anticancer Activity
by Phu Hiep Hoang, Thien Hien Tran and Van Khang Pham
Processes 2024, 12(1), 33; https://doi.org/10.3390/pr12010033 - 22 Dec 2023
Viewed by 765
Abstract
This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds [...] Read more.
This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds were identified in essential oils of the leaves and bark, among which many chemical compositions were identified for the first time in this plant. Salix babylonica essential oils demonstrated antibacterial activities against Gram-negative strains such as Pseudomonas aeruginosa (PA) and Escherichia coli and Gram-positive strains such as Staphylococcus aureus (SA), and demonstrated anti-cancer activities against three cancer cell lines (HepG2, MCF-7 cell, and A549). The evaluation of the ability to inhibit three strains of microorganisms and inhibit the growth of three cancer cell lines was first conducted using essential oils extracted from the plant species S. babylonica collected in Asia, which will be the basis for using essential oils of this plant in medicine. Full article
19 pages, 12001 KiB  
Article
Moringa oleifera L. Screening: SFE-CO2 Optimisation and Chemical Composition of Seed, Leaf, and Root Extracts as Potential Cosmetic Ingredients
by Júlia C. Kessler, Yaidelin A. Manrique, Isabel M. Martins, Alírio E. Rodrigues, Maria Filomena Barreiro and Madalena M. Dias
Separations 2023, 10(3), 210; https://doi.org/10.3390/separations10030210 - 17 Mar 2023
Viewed by 1311
Abstract
Moringa oleifera L. tree (Mo) has emerged as a rich alternative source of bioactive compounds to design cosmetic formulations. Supercritical carbon dioxide fluid extraction (SFE-CO2) was successfully applied on the screening of Mo seed, leaf, and root extracts. The extraction yield [...] Read more.
Moringa oleifera L. tree (Mo) has emerged as a rich alternative source of bioactive compounds to design cosmetic formulations. Supercritical carbon dioxide fluid extraction (SFE-CO2) was successfully applied on the screening of Mo seed, leaf, and root extracts. The extraction yield was evaluated by response surface methodology (RSM), for pressure and temperature ranges of 117–273 bar and 41–60 °C, respectively, using a design of experiments (DOE). The pressure significantly affected the results (α=0.05), with the highest extraction efficiency obtained at conditions above 195 bar. The extracts’ composition, evaluated by gas chromatography-mass spectrometer (GC-MS), revealed an increasing correlation between the pressure, total extract solubility, and mass of extract at a constant temperature, due to the higher extraction yield. Seed extracts presented more than 80% of oleic acid in relative composition (8.04 mgcompound∙gplantpart−1). Leaf extracts performed well for the obtainment of linolenic acid (>20%; 3.10 mg∙g−1), nonacosane (>22%; 0.46 mg∙g−1), and α-tocopherol (>20%; 0.21 mg∙g−1). Mo root resulted in higher relative composition for sterol molecules, despite its very low affinity with CO2. The most promising bioactive compounds, oleic acid and α-tocopherol, were more abundant when operating at 250 bar at 45 °C and 195 bar at 55 °C, for Mo seed and leaf SFE-CO2 extracts, respectively. Full article
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