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Vaccines
Special Issues
Comorbidity and Autoimmune Connective Tissue Disorders: From Bench to Bedside
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Comorbidity and Autoimmune Connective Tissue Disorders: From Bench to Bedside

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 21111

Special Issue Editors

Dr. Ilaria Mormile

E-Mail Website
Guest Editor
Department of Translational Medical Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
Interests: immunology; autoimmunity; allergic and inflammatory diseases; autoimmune diseases, allergen immunotherapy; biological therapies; bronchial asthma; fibroblasts; hereditary angioedema; bradykinin; VEGF
Prof. Dr. Francesca Wanda Rossi

E-Mail Website
Guest Editor
Department of Translational Medical Sciences (DiSMeT), Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, 80131 Naples, Italy
Interests: immunology; autoimmune diseases, allergic and inflammatory diseases; biological therapies; basophils; mast cells; fibroblasts; uPAR/uPAR system and its involvement in inflammation; VEGF and its receptors; FPRs receptors; tissue repair processes and tissue remodeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autoimmune connective tissue disorders are often associated with one or more comorbidities such as musculoskeletal, cardiovascular, pulmonary, or gastrointestinal diseases. Although some of these associations are well known, the relationship between comorbidities, polypharmacy, and symptoms of the underlying disease burden is often unclear. In addition, the diagnosis of many comorbidities of autoimmune connective tissue disorders is usually conducted at a late stage, and thus associated with poor prognosis. Therefore, novel high-sensitivity, standardized, non-invasive, cost- and time-effective tools are needed to diagnose these conditions early. With this broad research theme in mind, we welcome manuscripts from several perspectives, including basic, clinical and translational research, in order to provide important insight into the features, biomarkers and predictive factors of comorbidities in autoimmune connective tissue disorders. In addition, this theme could be useful for planning new intervention strategies for patients with autoimmune connective tissue disorders within a multi-specialist and multi-parametric approach. Studies on safety, efficacy, and recommendations for vaccination in individuals with autoimmune diseases and comorbidities are also welcome. We look forward to receiving your contributions to the Special Issue.

Dr. Ilaria Mormile
Prof. Dr. Francesca Wanda Rossi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmunity
  • autoimmune diseases
  • connective tissue disorders
  • comorbidity
  • immunology
  • immune system
  • inflammation

Published Papers (2 papers)

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18 pages, 1126 KiB  
Review
Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases
by Ilaria Mormile, Francesca Mosella, Piergiorgio Turco, Filomena Napolitano, Amato de Paulis and Francesca Wanda Rossi
Vaccines 2023, 11(5), 898; https://doi.org/10.3390/vaccines11050898 - 25 Apr 2023
Cited by 5 | Viewed by 3704
Abstract
Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue calcifications have been classified into five major types: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Autoimmune diseases are usually associated with dystrophic calcifications, including calcinosis cutis, occurring in damaged or devitalized tissues in the [...] Read more.
Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue calcifications have been classified into five major types: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Autoimmune diseases are usually associated with dystrophic calcifications, including calcinosis cutis, occurring in damaged or devitalized tissues in the presence of normal serum levels of calcium and phosphate. In particular, calcinosis cutis has been described in dermatomyositis, polymyositis, juvenile dermatomyositis, systemic sclerosis, systemic lupus erythematosus, primary Sjögren’s syndrome, overlap syndrome, mixed connective tissue disease, and rheumatoid arthritis. Calciphylaxis, a severe and life-threatening syndrome presenting with vascular calcifications and thrombosis, has also been associated with some autoimmune conditions. Due to the potentially disabling character of calcinosis cutis and calciphylaxis, physicians’ awareness about the clinical presentation and management of these diseases should be increased to select the most appropriate treatment option and avoid long-term complications. In this review, we aim to analyze the clinical features of calcinosis cutis and calciphylaxis associated with autoimmune diseases, and the main treatment strategies evaluated up to now for treating this potentially disabling disease. Full article
(This article belongs to the Special Issue Comorbidity and Autoimmune Connective Tissue Disorders: From Bench to Bedside)
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39 pages, 1033 KiB  
Systematic Review
New-Onset Rheumatic Immune-Mediated Inflammatory Diseases Following SARS-CoV-2 Vaccinations until May 2023: A Systematic Review
by Arvind Nune, Victor Durkowski, S. Sujitha Pillay, Bhupen Barman, Helen Elwell, Kaustubh Bora, Syed Bilgrami, Sajid Mahmood, Nasarulla Babajan, Srinivasan Venkatachalam, Lesley Ottewell and Ciro Manzo
Vaccines 2023, 11(10), 1571; https://doi.org/10.3390/vaccines11101571 - 08 Oct 2023
Cited by 4 | Viewed by 17015
Abstract
A comprehensive, up-to-date systematic review (SR) of the new-onset rheumatic immune-mediated inflammatory diseases (R-IMIDs) following COVID-19 vaccinations is lacking. Therefore, we investigated the demographics, management, and prognosis of new R-IMIDs in adults following SARS-CoV-2 vaccinations. A systematic literature search of Medline, Embase, Google [...] Read more.
A comprehensive, up-to-date systematic review (SR) of the new-onset rheumatic immune-mediated inflammatory diseases (R-IMIDs) following COVID-19 vaccinations is lacking. Therefore, we investigated the demographics, management, and prognosis of new R-IMIDs in adults following SARS-CoV-2 vaccinations. A systematic literature search of Medline, Embase, Google Scholar, LitCovid, and Cochrane was conducted. We included any English-language study that reported new-onset R-IMID in adults following the post-COVID-19 vaccination. A total of 271 cases were reported from 39 countries between January 2021 and May 2023. The mean age of patients was 56 (range 18–90), and most were females (170, 62.5%). Most (153, 56.5%) received the Pfizer BioNTech COVID-19 vaccine. Nearly 50% of patients developed R-IMID after the second dose of the vaccine. Vasculitis was the most prevalent clinical presentation (86, 31.7%), followed by connective tissue disease (66, 24.3%). The mean duration between the vaccine’s ‘trigger’ dose and R-IMID was 11 days. Most (220, 81.2%) received corticosteroids; however, 42% (115) received DMARDs such as methotrexate, cyclophosphamide, tocilizumab, anakinra, IV immunoglobulins, plasma exchange, or rituximab. Complete remission was achieved in 75 patients (27.7%), and 137 (50.6%) improved following the treatment. Two patients died due to myositis. This SR highlights that SARS-CoV-2 vaccines may trigger R-IMID; however, further epidemiology studies are required. Full article
(This article belongs to the Special Issue Comorbidity and Autoimmune Connective Tissue Disorders: From Bench to Bedside)
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