Allergology & Immunology

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 1972

Special Issue Editor


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Guest Editor
Department of Pediatrics, Sapienza University of Rome, Umberto I Hospital, 00161 Rome, Italy
Interests: pediatric immunology; primary immunodeficiency; vaccine; pediatric allergy; atopy; atopic diseases; pediatric asthma; pediatric rhinitis-rhinosinusitis; atopic dermatitis; pediatric eczema; pediatric vasculitis and immune mediated diseases; recurrent infections

Special Issue Information

Dear Colleagues, 

Allergology and immunology involves the management of disorders related to the immune system. These conditions range from the very common to the very rare, spanning all ages and encompassing various organ systems. Primary immunodeficiencies (PIDs) are heterogeneous disorders, characterized by variable clinical and immunological features. In 1999, the Italian primary immunodeficiency network(IPINet) was established within AIEOP (Italian Associationof Pediatric Haematology and Oncology).

This special issue aims to collect new and advanced research in Allergology and immunology, especially in newborns. The areas of the special issue covers but not limited tothe following aspects:

  • ontogeny of immune system in newborns;
  • rare allergies;
  • immunodeficiencies;
  • primary immunodeficiencies;
  • management of allergic diseases.

We are seeking high-quality contributions that explore allergology and immunology. We are pleased to invite you to contribute to this special issue. We welcome multidisciplinary work, including submissions from clinical researchers, behavioural and implementation scientists, epidemiologists, data analytics experts, public health practitioners, communication specialists, and others.

Dr. Marzia Duse
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergology
  • immunology
  • immune system
  • immunodeficiencies

Published Papers (1 paper)

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Research

17 pages, 2246 KiB  
Article
Early IgE Production Is Linked with Extrafollicular B- and T-Cell Activation in Low-Dose Allergy Model
by Dmitrii Borisovich Chudakov, Olga Dmitrievna Kotsareva, Maryia Vladimirovna Konovalova, Daria Sergeevna Tsaregorodtseva, Marina Alexandrovna Shevchenko, Anton Andreevich Sergeev and Gulnar Vaisovna Fattakhova
Vaccines 2022, 10(6), 969; https://doi.org/10.3390/vaccines10060969 - 17 Jun 2022
Cited by 3 | Viewed by 1706
Abstract
Despite its paramount importance, the predominant association of early IgE production with harmless antigens, via germinal-center B- and T-cell subpopulations or extrafollicular activation, remains unresolved. The aim of this work was to clarify whether the reinforced IgE production following the subcutaneous immunization of [...] Read more.
Despite its paramount importance, the predominant association of early IgE production with harmless antigens, via germinal-center B- and T-cell subpopulations or extrafollicular activation, remains unresolved. The aim of this work was to clarify whether the reinforced IgE production following the subcutaneous immunization of BALB/c mice with low antigen doses in withers adipose tissue might be linked with intensified extrafollicular or germinal-center responses. The mice were immunized three times a week for 4 weeks in the withers region, which is enriched in subcutaneous fat and tissue-associated B cells, with high and low OVA doses and via the intraperitoneal route for comparison. During long-term immunization with both low and high antigen doses in the withers region, but not via the intraperitoneal route, we observed a significant accumulation of B220-CD1d-CD5-CD19+ B-2 extrafollicular plasmablasts in the subcutaneous fat and regional lymph nodes but not in the intraperitoneal fat. Only low antigen doses induced a significant accumulation of CXCR4+ CXCR5- CD4+ extrafollicular T helpers in the withers adipose tissue but not in the regional lymph nodes or abdominal fat. Only in subcutaneous fat was there a combination of extrafollicular helper accumulation. In conclusion, extrafollicular B- and T-cell activation are necessary for early IgE class switching. Full article
(This article belongs to the Special Issue Allergology & Immunology)
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