Leishmania–Host Cell Interaction and Immunopathogenesis

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Pathogens-host Immune Interface".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4554

Special Issue Editors


E-Mail Website
Guest Editor
Institute of Tropical Medicine of Sao Paulo, Universidade de São Paulo, Sao Paulo, Brazil
Interests: immunology; vaccines; parasite-host interaction; miRNAs; immune metabolism

E-Mail Website
Guest Editor
Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil
Interests: immunology; immunopathogenesis; parasite-host interaction; immunoparasitology

E-Mail Website
Co-Guest Editor
Department of Biology, University of York, York, UK
Interests: immunology; immunopathogenesis; molecular pathology

E-Mail Website
Co-Guest Editor
Center for Infection & Immunity of Lille (CIIL), Institut Pasteur de Lille, Lille, France
Interests: immunoparasitology; cell biology of macrophages; protozoan host-pathogen interaction

Special Issue Information

Dear Colleagues,

Parasite–host interaction is crucial for the development of infection, and depending on how the host immune response is activated, it will lead to the resolution or progression of the infection. Even with vast knowledge about host interaction that has been generated in recent years, there are still gaps in knowledge regarding how host–parasite interaction takes place and how pathogenic and immunological processes evolve in infection. It is essential to fill the knowledge gaps because an understanding of what happens in this interaction may lead to the discovery of mechanisms and/or molecules that can be used as biomarkers, immunoprophylactics, and for the development of vaccines.

This Special Issue of MPDI Vaccines focuses on the most recent progress trends in the Leishmania–host cell interaction and immunopathogenesis. We are pleased to invite you to contribute with an original research article, review, or perspective on the latest research to highlight (i) novel molecules candidates to be biomarkers, (ii) novel host/parasite molecules that act in pathological mechanisms candidates for new therapeutical approaches, (iii) immune responses elicited by immune therapy (new therapeutical approaches), and (iv) modulation of immune metabolism. This Special Issue will put emphasis on Leishmania infection in human and experimental studies. 

We look forward to receiving your contributions.

Dr. Eduardo Milton Ramos-Sanchez
Dr. Luiza Campos Reis
Dr. Nidhi Sharma Dey
Dr. Fernando Real
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • leishmaniasis
  • immune response
  • pathogenesis
  • biomarkers
  • experimental model
  • immunomodulators

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1379 KiB  
Article
Central and Effector Memory Human CD4+ and CD8+ T Cells during Cutaneous Leishmaniasis and after In Vitro Stimulation with Leishmania (Viannia) braziliensis Epitopes
by Beatriz Coutinho de Oliveira, Ailton Alvaro da Silva, Marton Kaique de Andrade Cavalcante, Maria Edileuza Felinto de Brito, Maria Carolina Accioly Brelaz de Castro, Vanessa Lucília Silveira de Medeiros, Rafael de Freitas e Silva and Valéria Rêgo Alves Pereira
Vaccines 2023, 11(1), 158; https://doi.org/10.3390/vaccines11010158 - 11 Jan 2023
Cited by 3 | Viewed by 1900
Abstract
Cutaneous Leishmaniasis (CL) is a Neglected Tropical Disease characterized by skin ulcers caused by Leishmania spp. protozoans and there is no safe and effective vaccine to reduce its negative consequences. In a previous work by our group, we identified T cell epitopes of [...] Read more.
Cutaneous Leishmaniasis (CL) is a Neglected Tropical Disease characterized by skin ulcers caused by Leishmania spp. protozoans and there is no safe and effective vaccine to reduce its negative consequences. In a previous work by our group, we identified T cell epitopes of Leishmania (Viannia) braziliensis which stimulated patients’ T cells in vitro. In the present work, the peptides were tested as two pools for their ability to rescue memory T cells during natural infection by Leishmania. We analyzed the frequency of central memory (TCM, CD45RA-CD62L+) and effector memory (TEM, CD45RA + CD62L-) cells during active CL and post-treatment. In parallel, we investigated cell proliferation levels and the cytokines produced after stimulation. Interestingly, we observed higher frequencies (%) in CD4+ TEM during CL, and CD8+ TEM and CD8+ TCM during CL and post-treatment. Cell proliferation was increased, and a significant difference in expression was observed on T-bet and RORγT. Besides that, IFN-γ, IL-2, and IL-10 were detected in patient samples. Collectively, this dataset suggests that during CL there is an increase in the frequency of TCM and TEM, especially in the CD8 compartment. These results indicate a potentially immunogenic profile of the peptide pools, which can support the development of anti-Leishmania formulations. Full article
(This article belongs to the Special Issue Leishmania–Host Cell Interaction and Immunopathogenesis)
Show Figures

Figure 1

14 pages, 3552 KiB  
Article
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster
by Marco Antonio Cabrera González, Ana Alice Maia Gonçalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Júnior, Patrícia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chávez-Fumagalli, Marília Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira and Rodolfo Cordeiro Giunchettiadd Show full author list remove Hide full author list
Vaccines 2023, 11(1), 111; https://doi.org/10.3390/vaccines11010111 - 2 Jan 2023
Cited by 3 | Viewed by 2049
Abstract
Visceral leishmaniasis (VL) is a fatal disease caused by the protozoa Leishmania infantum for which dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) could be an important tool in the control of human and CVL by reducing the infection [...] Read more.
Visceral leishmaniasis (VL) is a fatal disease caused by the protozoa Leishmania infantum for which dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) could be an important tool in the control of human and CVL by reducing the infection pressure of L. infantum. Despite the CVL vaccine available on the market, the Brazilian Ministry of Health did not implement the use of it in their control programs. In this sense, there is an urgent need to develop more efficient vaccines. In this study, the association between two polymeric nanoformulations, (poly (D, L-lactic) acid (PLA) polymer) loading Leishmania amazonensis antigens, was evaluated as a potential immunobiological agent against VL using golden hamsters as an experimental model. The results indicated that no significant adverse reactions were observed in animals vaccinated with LAPSmP. LAPSmP presented similar levels of total anti-Leishmania IgG as compared to LAPSmG. The LAPSmP and LAPSmG groups showed an intense reduction in liver and spleen parasitic load by qPCR. The LAPSmP and LAPSmG vaccines showed exceptional results, indicating that they may be promising candidates as a VL vaccine. Full article
(This article belongs to the Special Issue Leishmania–Host Cell Interaction and Immunopathogenesis)
Show Figures

Figure 1

Back to TopTop