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Special Issue "Plant-Produced Vaccines, Therapeutics and Phytochemicals: Recent Developments, Challenges and Perspectives"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: 16 August 2023 | Viewed by 2011
Special Issue Editor
Interests: genetic engineeering; plant-based vaccines; plant virus research; agricultural biotechnology
Special Issues, Collections and Topics in MDPI journals
Special Issue in Viruses: Plant Virology Applications in Human Health
Special Issue in Pathogens: Advances in Plant Viruses
Special Issue Information
The development of vaccines from plants has been going on for over two decades. Vaccine production in plants requires time and a lot of effort. Researchers the world-over are involved in resolute endeavors to use all available schemes for the development of safe and efficacious vaccines against SARS-CoV-2 and other deadly viral diseases. With the introduction of transient expression technology, plant-based manufacture has been deemed as a feasible strategy which is increasingly gaining the attention of various pharmaceutical companies. Currently, few plant-produced vaccines against SARS-CoV-2 have reached the phase of preclinical and clinical trials. Nevertheless, in spite of the slow advancements in the commercialization of plant-derived vaccines, the success of clinical trials of plant-produced vaccines against influenza and COVID-19 in recent years renders great promise towards the commercialization of such plant-derived vaccines in the near future. Compared to xenobiotics, plant-based compounds are inherently safe to use due to their diminished toxicity, eco-friendliness and biocompatibility, and hence require less-rigorous appraisal. Plant-made vaccines could not be more important in tackling such unexpected pandemics as COVID-19.
The quest for efficacious plant-based biopharmaceuticals against deadly viruses such as SARS-CoV-2 is ongoing, and considering the novelty of newly emerging viruses and their variants, safety issues loom large over the use of phytochemicals and plant-based vaccines/therapeutics. This situation, combined with the dearth of information on the efficacy, quality and safety of phytochemicals, precludes their application in medical practices worldwide wherein uninvestigated usage of phytochemicals is not recommended. The marketing and well-defined use of plant-derived products must be authorized only after obtaining enough scientific data demonstrating that the pure constituent or active ingredient of the plant-based product has proven potency. The use of plant-derived vaccines is subject to stringent regulations which are, by-and-large, complex and time-consuming. The beneficial effects of plant-derived expression systems can be acquired only by circumventing regulatory hurdles.
This Special Issue aims to describe recent findings in plant-produced vaccines and the progress of plant-based vaccine candidates as well as therapeutics in pre-clinical and clinical trials. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the recent developments in the generation of plant-based vaccines, therapeutic/drug molecules, monoclonal antibodies and phytochemicals to preclude and combat infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2 viruses as well as other important viruses.
We look forward to receiving your contributions.
Dr. Srividhya Venkataraman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- molecular pharming
- regulatory issues