Transposable Elements in Parasites

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Vector-Borne Diseases".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 6437

Special Issue Editors


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Guest Editor
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Interests: schistosoma; helminths; bioinformatics; genomics; transposable elements

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Guest Editor
Laboratório de Ciências e Tecnologias Aplicadas em Saúde (LaCTAS), Instituto Carlos Chagas (ICC), Fiocruz-PR, Curitiba, Paraná, Brazil
Interests: molecular evolution; transposable elements; trypanosomatids; bioinformatics

Special Issue Information

Dear Colleagues, 

Transposable Elements (TEs) are mobile genetic entities found in almost all genomes studied so far. They can self-replicate and re-insert in the host genome with varying consequences. Traditionally conceived as “junk DNA,” our current knowledge of the role of TEs in genome evolution has modified our view and TEs are now regarded as powerful forces of genome evolution. 

Traditionally, TE research had been hampered by the high repetitive nature of the TEs. This  characteristic itself made the assembly of genomes an extremely challenging step. But now, and thanks primarily to single-molecule sequencing technologies, there is an increasing availbility of high-quality genome assemblies for all organisms, including parasites, facilitating the study of TEs within these fascinating organisms. 

This Special Issue on “Transposable Elements in Parasites” aims to highlight the functional and structural impact of transposable elements in the genomes of parasites, the current knowledge so far, and the future directions for this exciting new field of research. 

Dr. Anna V. Protasio
Dr. Adriana Ludwig
Guest Editors

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Keywords

  • Transposable elements
  • Genomics
  • Parasites
  • Protists
  • Nematodes
  • Flatworms

Published Papers (1 paper)

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Review

10 pages, 1257 KiB  
Review
Transposable Elements in the Genome of Human Parasite Schistosoma mansoni: A Review
by Gisele Strieder Philippsen
Trop. Med. Infect. Dis. 2021, 6(3), 126; https://doi.org/10.3390/tropicalmed6030126 - 9 Jul 2021
Cited by 1 | Viewed by 4195
Abstract
Transposable elements (TEs) are DNA sequences able to transpose within the host genome and, consequently, influence the dynamics of evolution in the species. Among the possible effects, TEs insertions may alter the expression and coding patterns of genes, leading to genomic innovations. Gene-duplication [...] Read more.
Transposable elements (TEs) are DNA sequences able to transpose within the host genome and, consequently, influence the dynamics of evolution in the species. Among the possible effects, TEs insertions may alter the expression and coding patterns of genes, leading to genomic innovations. Gene-duplication events, resulting from DNA segmental duplication induced by TEs transposition, constitute another important mechanism that contributes to the plasticity of genomes. This review aims to cover the current knowledge regarding TEs in the genome of the parasite Schistosoma mansoni, an agent of schistosomiasis—a neglected tropical disease affecting at least 250 million people worldwide. In this context, the literature concerning TEs description and TEs impact on the genomic architecture for S. mansoni was revisited, displaying evidence of TEs influence on schistosome speciation—mediated by bursts of transposition—and in gene-duplication events related to schistosome–host coevolution processes, as well several instances of TEs contribution into the coding sequences of genes. These findings indicate the relevant role of TEs in the evolution of the S. mansoni genome. Full article
(This article belongs to the Special Issue Transposable Elements in Parasites)
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