Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.1
2.9
Journals
TropicalMed
Special Issues
Viral and Bacterial Infection in People with Primary and Secondary...
share announcement

Viral and Bacterial Infection in People with Primary and Secondary Immunodeficiencies

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2152

Special Issue Editor

Dr. Luiz Euribel Prestes Carneiro

E-Mail Website
Guest Editor
Medical Emergency Department, Faculty of Medicine, Oeste Paulista University, Presidente Prudente, São Paulo, Brazil
Interests: infectious diseases; primary immunodeficiencies; secondary immunodeficiencies; onco-hematology

Special Issue Information

Dear Colleagues,

We are living in challenging times in this globalized world in which brand new and reemerging viral and bacterial agents are quickly spreading. We invite you to contribute a manuscript on but not restricted to viral and bacterial, but also parasitic and fungal infectious diseases in patients with primary or secondary immunodeficiencies.

Primary immunodeficiencies (PID) or inborn errors of immunity (IEI) are a complex array of rare genetic diseases that result from one or more abnormalities of the immune system. There are about 485 PID. Worldwide, they are underdiagnosed and present clinically as increased susceptibility to infections, autoimmunity, autoinflammatory diseases, allergy, bone marrow failure, and/or malignancy. Secondary immunodeficiencies (SID) are impairment of the immune system due to extrinsic factors, underlying medical conditions including hematological malignancy and rheumatic diseases, or medication. SID is up to 30 times more common than PID and is becoming increasingly common as new therapies are available. As in PID, in SID, viral infections can produce severe diseases if not diagnosed early and treated. On the other hand, bacterial infections are prevalent and are a significant cause of morbidity and a leading cause of mortality in both groups. They require multidisciplinary awareness and an approach to identification and management. The construction of protocols and sharing of information and experiences for the diagnosis and treatment of these infections constitute essential tools that enable practitioners to integrate and collaborate successfully to deliver improved outcomes for patients with PID or SID.

Dr. Luiz Euribel Prestes Carneiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • primary immunodeficiencies
  • secondary immunodeficiencies
  • viral–bacterial infections
  • diagnosis and treatment

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 4366 KiB  
Article
Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State, Brazil
by Luiz Euribel Prestes-Carneiro, Paula Andreia Martins Carrilho, Danielle Francisco Honorato de Barros Torelli, Jose Antonio Nascimento Bressa, Ana Carolina Gomes Parizi, Pedro Henrique Meireles Vieira, Fernanda Miranda Caliani Sa and Mauricio Domingues Ferreira
Trop. Med. Infect. Dis. 2024, 9(5), 104; https://doi.org/10.3390/tropicalmed9050104 - 6 May 2024
Viewed by 320
Abstract
Our aim was to determine the secondary antibody deficiency (SAD) profiles of patients in a mesoregion of São Paulo state, Brazil, focusing on infectious diseases. Demographic characteristics, and clinical and laboratory data were obtained from electronic files; infections were classified as organ-specific and [...] Read more.
Our aim was to determine the secondary antibody deficiency (SAD) profiles of patients in a mesoregion of São Paulo state, Brazil, focusing on infectious diseases. Demographic characteristics, and clinical and laboratory data were obtained from electronic files; infections were classified as organ-specific and graded as mild, moderate, life-threatening, and fatal. Non-Hodgkin’s lymphoma (NHL) accounted for 30% of patients, nephrotic syndrome (NS) 25%, chronic lymphocyte leukemia 20%, and multiple myeloma 15%. Patients with NS were younger than those in other groups, and hypo-γ-globulinemia was detected in 94.1%, IgG < 400 mg/dL in 60.0%, IgA < 40 mg/dL in 55.0%, and CD19 < 20 cells/mm3 in 30.0%. One hundred and one infections were found; 82.1% were classified as mild or moderate, 7.9% as life-threatening, and 3.0% as fatal. Respiratory tract infections were more prevalent (41.5%), and pneumonia accounted for 19.8%. Lower levels of infections were found in patients with NS compared with NHL (p = 0.0001). Most patients progressed to hypo-γ-globulinemia and SAD after treatment with immunosuppressants, and mild and moderate infections were predominant. These therapies are increasing in patients with different diseases; therefore, monitoring hypo-γ-globulinemia and infections may help to identify patients at high risk for severe complications, antibiotic prophylaxis or treatment, and immunoglobulin replacement. Full article
(This article belongs to the Special Issue Viral and Bacterial Infection in People with Primary and Secondary Immunodeficiencies)
►▼ Show Figures

Figure 1

9 pages, 261 KiB  
Article
HCV Co-Infection and Its Genotypic Distribution in HIV-Infected Patients in Nepalese Population
by Uday Kant Sah, Anil Kumar Sah, Mehraj Ansari, Priyanka Chaudhary, Saurav Gupta, Pawan Kumar and Jay Prakash Sah
Trop. Med. Infect. Dis. 2023, 8(7), 361; https://doi.org/10.3390/tropicalmed8070361 - 13 Jul 2023
Viewed by 1260
Abstract
Hepatitis C Virus (HCV) co-infection and its genotypic distribution in people living with Human Immunodeficiency Virus (HIV) show global inconsistency. Therefore, the present study aimed to investigate the prevalence and genotypic distribution patterns of HCV, along with viral load, in people living with [...] Read more.
Hepatitis C Virus (HCV) co-infection and its genotypic distribution in people living with Human Immunodeficiency Virus (HIV) show global inconsistency. Therefore, the present study aimed to investigate the prevalence and genotypic distribution patterns of HCV, along with viral load, in people living with HIV. This cross-sectional study was conducted at SRL Diagnostics Nepal, Pvt. Ltd. in 203 HIV-seropositive patients attending the Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal from October 2021 to May 2022. The viral load and HCV genotypes were estimated from RNA extracted from the blood sample (plasma) of PLHIV by using a standard Q-PCR protocol. HCV infection was considered as a core variable, whereas covariates used for this study were duration of HIV infection, age, sex, and ART regimen. Out of total 203 PLHIV, the estimated prevalence of HCV co-infection was 115 (56.6%). Male gender was a unique characteristic associated with a high prevalence of HCV co-infection compared to females. The HCV viral load among PLHIV ranged from 34 to 3,000,000 IU/mL. Among HCV co-infected PLHIV, 56 (48.69%) had a low level of HCV viral load. Interestingly, only 3 (2.6%) patients had an HCV viral load higher than 3,000,000 IU/mL. Diverse HCV genotypes were found in the population, including genotypes 1, 1a, 3a, 5a, and 6. However, genotype 3 was the most prevalent HCV variant among HCV-co-infected PLHIV, with a distribution of 36 (61.1%) and viral load ranging from 34 to 3000 IU/mL. HCV co-infection is frequent in the Nepalese population of people living with HIV, particularly due to HCV genotypic variant 3. The findings of this study could be useful for the management and clearance of the HCV co-infection in PLHIV, aiming to provide a good quality of life. Full article
(This article belongs to the Special Issue Viral and Bacterial Infection in People with Primary and Secondary Immunodeficiencies)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop