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Toxins
Special Issues
Bacterial Secretion Systems, Anti-host Effectors and Toxins: Towards the New Microbiology
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Bacterial Secretion Systems, Anti-host Effectors and Toxins: Towards the New Microbiology

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 7790

Special Issue Editor

Dr. Abderrahman Hachani

E-Mail
Guest Editor
University of Melbourne, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Melbourne, Australia

Special Issue Information

In recent years, the study of molecular mechanisms driving bacterial pathogenesis has significantly advanced our understanding of eukaryotic cell biology. Bacteria have evolved a diverse array of secretion systems (SS) devoted to protein transport. To date, up to ten types of secretion systems have been identified (TISS-TXSS), differing in their composition, biogenesis, organization, function and dynamic.

These complex machineries span bacterial membranes to transport their cargo from the bacterial cytosol to the external milieu or to directly inject them into targeted host cells.  These proteins, called effectors, target various host cellular pathways to affect or antagonize antibacterial host responses to bacterial pathogen infection.

In this Special Issue, we seek contributions focusing on the most recent advances made in the field of bacterial secretion systems and anti-host effectors. We strongly encourage the submission of manuscripts providing a critical review of the current landscape of bacterial secretion systems and their cognate effectors, in light of the new developments in effector biology and the technical limitations hampering these progresses. We also welcome mechanistic studies delineating the role of bacterial effectors during host infection.

Finally, we are encouraging the submission of manuscripts reviewing emerging technologies harnessing the biochemical activities of effectors, methodologies facilitating the discovery of new effectors from bacterial genome mining; and the use of alternative infection models facilitating the functional characterization of effectors in pathogenesis.

Dr. Abderrahman Hachani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bacterial Secretion Systems
  • Effectors
  • Cell biology
  • Cell autonomous immunity
  • Host-pathogen interactions
  • Toxins
  • Alternative infection models
  • Genomics

Published Papers (2 papers)

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Review

16 pages, 781 KiB  
Review
Delivery of Toxins and Effectors by Bacterial Membrane Vesicles
by Adrian Macion, Agnieszka Wyszyńska and Renata Godlewska
Toxins 2021, 13(12), 845; https://doi.org/10.3390/toxins13120845 - 26 Nov 2021
Cited by 13 | Viewed by 4554
Abstract
Pathogenic bacteria interact with cells of their host via many factors. The surface components, i.e., adhesins, lipoproteins, LPS and glycoconjugates, are particularly important in the initial stages of colonization. They enable adhesion and multiplication, as well as the formation of biofilms. In contrast, [...] Read more.
Pathogenic bacteria interact with cells of their host via many factors. The surface components, i.e., adhesins, lipoproteins, LPS and glycoconjugates, are particularly important in the initial stages of colonization. They enable adhesion and multiplication, as well as the formation of biofilms. In contrast, virulence factors such as invasins and toxins act quickly to damage host cells, causing tissue destruction and, consequently, organ dysfunction. These proteins must be exported from the bacterium and delivered to the host cell in order to function effectively. Bacteria have developed a number of one- and two-step secretion systems to transport their proteins to target cells. Recently, several authors have postulated the existence of another transport system (sometimes called “secretion system type zero”), which utilizes extracellular structures, namely membrane vesicles (MVs). This review examines the role of MVs as transporters of virulence factors and the interaction of toxin-containing vesicles and other protein effectors with different human cell types. We focus on the unique ability of vesicles to cross the blood–brain barrier and deliver protein effectors from intestinal or oral bacteria to the central nervous system. Full article
(This article belongs to the Special Issue Bacterial Secretion Systems, Anti-host Effectors and Toxins: Towards the New Microbiology)
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16 pages, 2273 KiB  
Review
Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens
by Arthur Bienvenu, Eric Martinez and Matteo Bonazzi
Toxins 2021, 13(10), 713; https://doi.org/10.3390/toxins13100713 - 9 Oct 2021
Cited by 5 | Viewed by 2640
Abstract
Intracellular bacterial pathogens establish their replicative niches within membrane-encompassed compartments, called vacuoles. A subset of these bacteria uses a nanochannel called the type 4 secretion system (T4SS) to inject effector proteins that subvert the host cell machinery and drive the biogenesis of these [...] Read more.
Intracellular bacterial pathogens establish their replicative niches within membrane-encompassed compartments, called vacuoles. A subset of these bacteria uses a nanochannel called the type 4 secretion system (T4SS) to inject effector proteins that subvert the host cell machinery and drive the biogenesis of these compartments. These bacteria have also developed sophisticated ways of altering the innate immune sensing and response of their host cells, which allow them to cause long-lasting infections and chronic diseases. This review covers the mechanisms employed by intravacuolar pathogens to escape innate immune sensing and how Type 4-secreted bacterial effectors manipulate host cell mechanisms to allow the persistence of bacteria. Full article
(This article belongs to the Special Issue Bacterial Secretion Systems, Anti-host Effectors and Toxins: Towards the New Microbiology)
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