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Toxins
Special Issues
Mass-Spectrometry-Based Approaches for Mycotoxin Analysis: From Target Detection to Metabolite...
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Mass-Spectrometry-Based Approaches for Mycotoxin Analysis: From Target Detection to Metabolite Discovery

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 1636

Special Issue Editors

Dr. Biancamaria Ciasca

E-Mail Website
Guest Editor
Institute of Sciences of Food Production, National Research Council of Italy, Via Amendola, 122/O, 70126 Bari, Italy
Interests: development and standardization of methods for the analysis of mycotoxins and pesticides in food matrices based on mass spectrometry techniques and immunoassays; the development of targeted and untargeted approaches to plant metabolomics studies based on open-source workflow for data processing and interpretation
Special Issues, Collections and Topics in MDPI journals
Dr. Veronica Maria Teresa Lattanzio

E-Mail Website1 Website2
Guest Editor
Institute of Sciences of Food Productions, National Research Council of Italy, Via Amendola 200/O, 70126 Bari, Italy
Interests: food safety; food safety policy; development and validation of analytical methods for mycotoxin detection based either on mass spectrometry techniques and immunoassays, including organization of collaborative trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mycotoxin contamination is a major problem affecting global food security. Global warming and climate change affect mycotoxin production, leading to the emergence of new and increasingly abundant combinations of mycotoxins in food and feed. Accumulating evidence points towards a range of mycotoxins that are neither routinely analyzed nor regulated by law, including so-called emerging mycotoxins and modified mycotoxins (conjugated forms of mycotoxins generated as a defense mechanism against infected plants or formed during food processing). The co-occurrence of multiple mycotoxins in food is also a growing health concern due to their interaction effects, which have not yet been studied in detail. Finally, the complex biosynthetic processes involved in the production of mycotoxins, which are associated with the interaction between the pathogenic fungi, the host and the environment, are not yet well understood. Mass-spectrometry-based approaches represent a powerful tool to investigate the above-mentioned issues. Mass spectroscopy coupled with liquid chromatography is a valuable tool for the detection and analysis of multi-mycotoxins, which is able to provide information on a wide range of metabolites involved in mycotoxin production. The latest developments in this prove the possibility of detecting not only multiple mycotoxins but also the total metabolic phenotypes in a biological system. Topics of interest in this Special Issue include the development and/or validation of multi-mycotoxin methods based on mass spectrometry coupled to liquid chromatography, the monitoring of multiple mycotoxins in food and feed, metabolomic studies of the fate of mycotoxins in biological systems or food processing, including the identification or characterization of novel toxins or related metabolites.

Dr. Biancamaria Ciasca
Dr. Veronica Maria Teresa Lattanzio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxin occurrence
  • emerging and modified mycotoxins
  • multi mycotoxins method
  • metabolomics
  • mass spectrometry
  • food safety

Published Papers (1 paper)

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Research

10 pages, 307 KiB  
Article
Analysis of Patulin in Apple Products Marketed in Belgium: Intra-Laboratory Validation Study and Occurrence
by Emmanuel K. Tangni, Julien Masquelier and Els Van Hoeck
Toxins 2023, 15(6), 368; https://doi.org/10.3390/toxins15060368 - 30 May 2023
Cited by 4 | Viewed by 1281
Abstract
Apple and apple derivatives (e.g., juices, puree) are the most important foodstuffs contaminated with patulin (PAT) in the human diet. To routinely monitor these foodstuffs and ensure that the PAT levels are below the maximum permitted levels, a method using liquid chromatography combined [...] Read more.
Apple and apple derivatives (e.g., juices, puree) are the most important foodstuffs contaminated with patulin (PAT) in the human diet. To routinely monitor these foodstuffs and ensure that the PAT levels are below the maximum permitted levels, a method using liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) has been developed. Afterwards, the method was successfully validated, reaching quantification limits of 1.2 μg/L for apple juice and cider, and 2.1 μg/kg for puree. Recovery experiments were performed with samples fortified with PAT in the range of 25–75 μg/L for juice/cider and 25–75 μg/kg for puree. The results show overall average recovery rates of 85% (RSDr = 13.1%) and 86% (RSDr = 2.6%) with maximum extended uncertainty (Umax, k = 2) of 34 and 35% for apple juice/cider and puree, respectively. Next, the validated method was applied to 103 juices, 42 purees and 10 ciders purchased on the Belgian market in 2021. PAT was not found in the cider samples, but it was present in 54.4% of the tested apple juices (up to 191.1 μg/L) and 7.1% of the puree samples (up to 35.9 μg/kg). When comparing the results to the maximum levels set by Regulation EC n° 1881/2006 (i.e., 50 μg/L for juices and 25 μg/kg for puree for adults, and 10 μg/kg for infants and young children), exceedances were observed in five apple juices and one puree sample, for infants and young children. Using these data, a potential risk assessment for consumers can be suggested, and it is found that the quality of apple juices and purees sold in Belgium needs further regular surveillance. Full article
(This article belongs to the Special Issue Mass-Spectrometry-Based Approaches for Mycotoxin Analysis: From Target Detection to Metabolite Discovery)
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