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Toxins
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Aspergillus flavus and Aflatoxins (Volume III)
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Aspergillus flavus and Aflatoxins (Volume III)

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1600

Special Issue Editors

Prof. Dr. Shihua Wang

E-Mail Website
Guest Editor
Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province, Key Laboratory of Biopesticide and Chemical Biology of Education Ministry, School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Interests: fungi; A. flavus; secondary metabolite; mycotoxins; biosynthetic pathway; antibody; detection; regulation; control; post-translation modification
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yang Liu

E-Mail Website
Guest Editor
School of Food Science and Engineering, Foshan University, Foshan 528231, China
Interests: fungi toxins; A. flavus; prevention, control and detoxification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that aflatoxins (AFs), a type of toxic and carcinogenic secondary metabolites mainly produced by Aspergillus flavus, not only represent a serious threat to human and animal health, but also cause significant economic losses regarding food and feed. Since the discovery of AFs in 1960s, significant research progress on A. flavus and AFs has been achieved. With the rapid development of molecular biology, genomics and bioinformatics, the research of A. flavus and AFs has entered a new era, especially regarding the regulation mechanism of growth and development and secondary metabolism, the discovery of novel natural products, the synthesis mechanism of natural products, and toxin detection. The regulation mechanism is very complex and includes the transcription level, translational level, and post-translational modification (PTM) level. Among them, PTM is one of the current research hotspots, including novel succinylation and benzoylation modifications. A. flavus conidia and sclerotium, as the primary sources of infection, play critical roles in the effects of A. flavus and aflatoxins. In addition, the highly sensitive detection of toxins is also an effective way to reduce losses caused by A. flavus and aflatoxins. Therefore, it is important that the regulation mechanisms of the growth and development of A. flavus and its toxin biosynthesis are revealed, and efficient and sensitive detection methods are developed.

The current Special Issue aims to collect papers related to A. flavus and aflatoxins, on subjects ranging from molecular mechanisms to detection methods, and this includes original research articles, and review articles. As the guest editors, we look forward to receiving papers from researchers and experts.

Prof. Dr. Shihua Wang
Prof. Dr. Yang Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Aspergillus flavus
  • growth and development
  • aflatoxins
  • secondary metabolism
  • post-translational modification
  • detection

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Published Papers (1 paper)

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Research

13 pages, 1950 KiB  
Article
Recombinant Oxidase from Armillaria tabescens as a Potential Tool for Aflatoxin B1 Degradation in Contaminated Cereal Grain
by Igor Sinelnikov, Oleg Mikityuk, Larisa Shcherbakova, Tatyana Nazarova, Yury Denisenko, Alexandra Rozhkova, Natalia Statsyuk and Ivan Zorov
Toxins 2023, 15(12), 678; https://doi.org/10.3390/toxins15120678 - 30 Nov 2023
Viewed by 1172
Abstract
Forage grain contamination with aflatoxin B1 (AFB1) is a global problem, so its detoxification with the aim of providing feed safety and cost-efficiency is still a relevant issue. AFB1 degradation by microbial enzymes is considered to be a promising detoxification approach. In this [...] Read more.
Forage grain contamination with aflatoxin B1 (AFB1) is a global problem, so its detoxification with the aim of providing feed safety and cost-efficiency is still a relevant issue. AFB1 degradation by microbial enzymes is considered to be a promising detoxification approach. In this study, we modified an previously developed Pichia pastoris GS115 expression system using a chimeric signal peptide to obtain a new recombinant producer of extracellular AFB1 oxidase (AFO) from Armillaria tabescens (the yield of 0.3 g/L), purified AFO, and selected optimal conditions for AFO-induced AFB1 removal from model solutions. After a 72 h exposure of the AFB1 solution to AFO at pH 6.0 and 30 °C, 80% of the AFB1 was degraded. Treatments with AFO also significantly reduced the AFB1 content in wheat and corn grain inoculated with Aspergillus flavus. In grain samples contaminated with several dozen micrograms of AFB1 per kg, a 48 h exposure to AFO resulted in at least double the reduction in grain contamination compared to the control, while the same treatment of more significantly (~mg/kg) AFB1-polluted samples reduced their contamination by ~40%. These findings prove the potential of the tested AFO for cereal grain decontamination and suggest that additional studies to stabilize AFO and improve its AFB1-degrading efficacy are required. Full article
(This article belongs to the Special Issue Aspergillus flavus and Aflatoxins (Volume III))
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