Toxicity of Cosmetic and Cosmeceutics Formulations

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3584

Special Issue Editor


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Guest Editor
1. Department of Toxicology and Drug Industry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Street, 300041 Timişoara, Romania
2. Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Interests: toxicology; nanoparticles; natural and synthetic drugs; natural compounds; derivatization
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Special Issue Information

Dear Colleagues,

The cosmetics industry is in a continuous development based on the extraordinarily high consumption of cosmetics. Despite the visible benefits of these products, more and more invisible risks, mostly related to toxicity, are being reported. Firstly, the composition of cosmetics and cosmeceutics involves the addition of chemical compounds that increase their value, quality, lifespan, etc. Secondly, nanotechnology is beginning to be present in a plethora of cosmetics, and the health risks are not detailed enough. Thirdly, safe testing of cosmetics oscillates between in vitro methods, reconstructed human tissue models, and the selection of human volunteers, without a mandatory reference mark. Last but not least, cosmetovigilance is not as extensive as it should be due to incomplete and evasive legislation. Consequently, the use of cosmetics represents a public health problem considering the toxic reactions they can generate, from mild hypersensitivity to lethal intoxication, and the biological risks (cytotoxicity, mutagenicity, neurotoxicity, etc.) must be carefully analyzed.

We are pleased to invite you to contribute with interesting topics that will help to raise awareness of the safety of cosmetics production and use. This Special Issue, “Toxicity of Cosmetic and Cosmeceutics Formulations”, aims to bring together relevant research submitted in the form of original research, meta-analyses, short communication, study designs, and reviews. These can address the composition of cosmetics, the types of nano- and micro-compounds used in cosmetics, methods of production and testing cosmetics, legislative aspects related to cosmetics, differences between cosmetics and cosmeceutics, etc.

I look forward to receiving your contributions.

Dr. Iulia Pinzaru
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cosmetics
  • cosmeceutics
  • nanoparticles
  • microparticles
  • antiaging
  • skincare
  • skin cancer
  • safety
  • toxicity
  • legislative aspects

Published Papers (1 paper)

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Research

11 pages, 3513 KiB  
Article
Rutin Exerts Cytotoxic and Senescence-Inducing Properties in Human Melanoma Cells
by Iulia Pinzaru, Raul Chioibas, Iasmina Marcovici, Dorina Coricovac, Razvan Susan, Denisa Predut, Doina Georgescu and Cristina Dehelean
Toxics 2021, 9(9), 226; https://doi.org/10.3390/toxics9090226 - 19 Sep 2021
Cited by 16 | Viewed by 2886
Abstract
Malignant melanoma represents the deadliest type of skin cancer with narrow treatment options in advanced stages. Herbal constituents possessing anticancer properties occupy a particular spot in melanoma research as potential chemotherapeutics. Rutin (RUT) is a natural compound exerting antioxidant, antimicrobial, anti-inflammatory, UV-filtering, and [...] Read more.
Malignant melanoma represents the deadliest type of skin cancer with narrow treatment options in advanced stages. Herbal constituents possessing anticancer properties occupy a particular spot in melanoma research as potential chemotherapeutics. Rutin (RUT) is a natural compound exerting antioxidant, antimicrobial, anti-inflammatory, UV-filtering, and SPF-enhancing activities that are beneficial to the skin; however, its effect as an anti-melanoma agent is less investigated. The current study is focused on assessing the cytotoxic potential of RUT against two different human melanoma cell lines: RPMI-7951 and SK-MEL-28 by evaluating its impact in terms of cell viability, cells’ morphology, and nuclear aspect assessment, and senescence-inducing properties. The results indicate a dose-dependent decrease in the viability of both cell lines, with calculated IC50 values of 64.49 ± 13.27 µM for RPMI-7951 cells and 47.44 ± 2.41 µM for SK-MEL-28, respectively, accompanied by a visible reduction in the cell confluency and apoptotic features within the cell nuclei. RUT exerted a senescence-inducing property highlighted by the elevated expression of senescent-associated beta-galactosidase (SA-β-gal) in SK-MEL-28 cells. Despite the in vitro anti-melanoma effect revealed by our results, further studies are required to elucidate the mechanisms of RUT-induced cytotoxicity and senescence in melanoma cells. Full article
(This article belongs to the Special Issue Toxicity of Cosmetic and Cosmeceutics Formulations)
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