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Toxics
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New Insights on Environmental Chemical Exposure and Toxicological Mechanism
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New Insights on Environmental Chemical Exposure and Toxicological Mechanism

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 5595

Special Issue Editors

Dr. Huifeng Yue

E-Mail Website
Guest Editor
College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan 030006, China
Interests: environmental health & toxicology
Prof. Dr. Nan Sang

E-Mail Website
Guest Editor
College of Environment and Resource, Research Center for Environment and Health, Shanxi University, Taiyuan 030006, China
Interests: air pollution and human health risk; environmental chemical exposure and toxicological mechanism

Special Issue Information

Dear Colleagues,

Environmental chemical exposure is a significant public health concern and an environmental issue worldwide. Many environmental chemicals have been shown to pose risks to human health, ranging from developmental abnormalities and cancer to neurological disorders and immune dysfunction. However, the exposure patterns and the toxic mechanisms of emerging environmental pollutants remain need to be further examined. Understanding the extent of exposure to toxic chemicals in the environment can help us identify potential sources of contamination and develop strategies for exposure reduction.

Topics of interest include but are not limited to: the identification and characterization of toxic chemicals, especially thoes of the emerging environmental pollutants, in the environment, the assessment of exposure routes and levels, the analysis of toxicological pathways and their underlying mechanisms, and the development of new approaches for risk assessment and management.

Dr. Huifeng Yue
Prof. Dr. Nan Sang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental exposure
  • emerging environmental pollutants
  • toxicological pathways
  • mechanisms
  • exposure levels

Published Papers (2 papers)

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Research

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10 pages, 2084 KiB  
Article
New Perspectives on the Risks of Hydroxylated Polychlorinated Biphenyl (OH-PCB) Exposure: Intestinal Flora α-Glucosidase Inhibition
by Guoqiang Qin, Ruoyong Jia, Juntang Xue, Li Chen, Yang Li, Weiming Luo, Xiaomin Wu, Tianfeng An and Zhongze Fang
Toxics 2024, 12(4), 237; https://doi.org/10.3390/toxics12040237 - 24 Mar 2024
Viewed by 712
Abstract
Polychlorinated biphenyls (PCBs) are a group of colorless and odorless environmental pollutants with a wide range of toxic effects. Some PCBs, especially less chlorinated ones, will rapidly undergo phase I metabolism after entering the body, and hydroxylated polychlorinated biphenyls (OH-PCBs) are the main [...] Read more.
Polychlorinated biphenyls (PCBs) are a group of colorless and odorless environmental pollutants with a wide range of toxic effects. Some PCBs, especially less chlorinated ones, will rapidly undergo phase I metabolism after entering the body, and hydroxylated polychlorinated biphenyls (OH-PCBs) are the main metabolites of PCBs. Intestinal flora α-glucosidase is a common carbohydrate-active enzyme which is ubiquitous in human intestinal flora. It can convert complex dietary polysaccharides into monosaccharides, assisting the body in degrading complex carbohydrates and providing energy for the survival and growth of bacterial flora. The present study aims to investigate the inhibition of the activity of intestinal flora α-glucosidase by OH-PCBs. 4-Nitrophenyl-α-D-glucopyranoside (PNPG) was used as a probe substrate for α-glucosidase, and in vitro incubation experiments were conducted to study the inhibition of 26 representative OH-PCBs on α-glucosidase. Preliminary screening of in vitro incubation was performed with 100 μM of OH-PCBs. The results showed that 26 OH-PCBs generally exhibited strong inhibition of α-glucosidase. The concentration-dependent inhibition and half inhibition concentrations (IC50s) of OH-PCBs on α-glucosidase were determined. 4′-OH-PCB 86 and 4′-OH-PCB 106 were chosen as representative OH-PCBs, and the inhibition kinetic parameters (Kis) of inhibitors for α-glucosidase were determined. The inhibition kinetic parameters (Kis) of 4′-OH-PCB 86 and 4′-OH-PCB 106 for α-glucosidase are 1.007 μM and 0.538 μM, respectively. The silico docking method was used to further analyze the interaction mechanism between OH-PCBs and α-glucosidase. All these results will help us to understand the risks of OH-PCB exposure from a new perspective. Full article
(This article belongs to the Special Issue New Insights on Environmental Chemical Exposure and Toxicological Mechanism)
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Review

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38 pages, 1819 KiB  
Review
Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives
by Xiaoyun Wu, Yuchai Tian, Huizhen Zhu, Pengchong Xu, Jiyue Zhang, Yangcheng Hu, Xiaotong Ji, Ruifeng Yan, Huifeng Yue and Nan Sang
Toxics 2023, 11(12), 1000; https://doi.org/10.3390/toxics11121000 - 07 Dec 2023
Cited by 1 | Viewed by 4517
Abstract
Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their [...] Read more.
Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their endocrine-disrupting effects on female reproductive health. To provide a basis for future research on environmental interference and reproductive health, we reviewed relevant studies on the exposure patterns and levels of bisphenols in environmental matrices and humans (including susceptible populations such as pregnant women and children). In addition, we focused on in vivo, in vitro, and epidemiological studies evaluating the effects of bisphenols on the female reproductive system (the uterus, ovaries, fallopian tubes, and vagina). The results indicate that bisphenols cause structural and functional damage to the female reproductive system by interfering with hormones; activating receptors; inducing oxidative stress, DNA damage, and carcinogenesis; and triggering epigenetic changes, with the damaging effects being intergenerational. Epidemiological studies support the association between bisphenols and diseases such as cancer of the female reproductive system, reproductive dysfunction, and miscarriage, which may negatively affect the establishment and maintenance of pregnancy. Altogether, this review provides a reference for assessing the adverse effects of bisphenols on female reproductive health. Full article
(This article belongs to the Special Issue New Insights on Environmental Chemical Exposure and Toxicological Mechanism)
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