Holistic Toxicological Approaches in Forensic Sciences Applications: New Perspectives and Approaches to Improve Casework

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Novel Methods in Toxicology Research".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 8768

Special Issue Editors


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Department of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, 98166 Messina, Italy
Interests: forensic geology; environmental forensics; applied geophysics; ERT; GPR; forensic trace and micro-trace analysis; groundwater pollution; criminalistics
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William R. Maples Center for Forensic Medicine, University of Florida, 4800 SW 35th Drive, Gainesville, FL 32608, USA
Interests: forensic entomology; mass fatality management; disaster victim identification; veterinary and wildlife forensic sciences

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Section of Legal Medicine, Department of Biomedical Sciences, Dental and of Morphological and Functional Images, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy
Interests: forensic science; forensic genetics; forensic pathology; social medicine; medical malpractice; CSI; BPA; genetics screneening in occupational exposure

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Department of Chemical, Biological, Pharmaceutical and Environmentale Sciences, University of Messina, Messina, Italy
Interests: natural compounds; plant extracts; pharmaceutical biology; phytochemistry; toxicology; environmental toxicology; forensic sciences
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Department of Comparative, Diagnostic & Population Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32608, USA
Interests: veterinary forensic pathology; relay toxicosis; animal poisoning; animal cruelty; decomposition

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Department of Chemical, Biological, Pharmaceutical and Environmentale Sciences, University of Messina, Messina, Italy
Interests: natural compounds; plant extracts; pharmacology; toxicology; environmental toxicology; forensic sciences; pharmacokinetic and pharmacodynamic studies; clinical studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Environmental abiotic and biotic stressors include inorganic (rocks and minerals) and organic (plants and animals) factors. In the broad spectrum of the planet’s ecosystems, these factors may interact and, in some cases, release harmful substances affecting living organisms (humans, domestic and wild animals, and plants) and non-living matter. In recent years, there has been increased interest in the epigenetic effects of nanoplastic, algal toxin, and mycotoxin microconcentrations. Considering this, a multidisciplinary approach involving experts in the environmental and life sciences (toxicology, legal medicine, entomology, veterinary forensic science, biology, and geology) may provide helpful information to develop and optimize new protocols for toxicological screening. This holistic approach could be a support tool to easily detect adulterants, substituents, harmful environmental interactions, or poisons to better manage and protect the environment, improve public health for future generations, and develop forensic sciences applications.

Dr. Roberta Somma
Dr. Jason H. Byrd
Dr. Daniela Sapienza
Dr. Antonella Smeriglio
Prof. Dr. Adam Stern
Dr. Domenico Trombetta
Guest Editors

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Keywords

  • environmental abiotic and biotic stressors
  • nanoplastic
  • algal toxins
  • mycotoxins poisons

Published Papers (2 papers)

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Research

5 pages, 204 KiB  
Communication
Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats
by Adam W. Stern, Daliana Roig, Courtney Valerio and Thomas Denagamage
Toxics 2023, 11(8), 685; https://doi.org/10.3390/toxics11080685 - 10 Aug 2023
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Abstract
Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for [...] Read more.
Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The aim of this study was to evaluate differences in VUN, CREA, and magnesium (MG) concentrations in vitreous humor collected postmortem from cats that presented with renal or post-renal disease and cats without renal or post-renal disease. Nine cats with renal or post-renal disease and twenty cats without renal or post-renal disease that underwent autopsy were used in this study. Collection of postmortem vitreous humor was performed, and vitreous samples were frozen at −80 °C for a minimum of 24 h prior to analysis using an in-clinic dry chemistry analyzer. Overall, there were statistically significant differences for VUN, CREA, and MG between cats with renal or post-renal disease and cats without renal or post-renal disease. Analysis of vitreous humor from cats suspected to have renal or post-renal disease can provide useful diagnostic information pertaining to renal function and issues in the urethra and urinary bladder. Future studies exploring postmortem vitreous chemistry in cats are warranted. Full article
10 pages, 1123 KiB  
Article
Reasons, Form of Ingestion and Side Effects Associated with Consumption of Amanita muscaria
by Michal Ordak, Aleksandra Galazka, Tadeusz Nasierowski, Elzbieta Muszynska and Magdalena Bujalska-Zadrozny
Toxics 2023, 11(4), 383; https://doi.org/10.3390/toxics11040383 - 17 Apr 2023
Cited by 1 | Viewed by 6975
Abstract
In recent months, there has been a new trend involving the consumption of Amanita muscaria. The aim of this article was to investigate the reasons for consumption, the form taken and the adverse symptoms that were indicated by those consuming Amanita muscaria [...] Read more.
In recent months, there has been a new trend involving the consumption of Amanita muscaria. The aim of this article was to investigate the reasons for consumption, the form taken and the adverse symptoms that were indicated by those consuming Amanita muscaria. After analysing 5600 comments, 684 people were included in the study, who, in social media groups such as Facebook, stated the purpose of consuming the mushroom (n = 250), the form of mushroom they were taking (n = 198) or the adverse symptoms they experienced (n = 236). The gender of the subjects differentiated the parameters analysed. In the study group of women, the main purpose of consuming Amanita muscaria was to reduce pain, as well as to reduce skin problems, while in men it was mainly to relieve stress, reduce the severity of depressive symptoms and reduce insomnia (p < 0.001). With regard to the form of mushroom ingested, tincture was predominant in the women’s study group, while dried was predominant in the men (p < 0.001). In terms of side effects, women reported primarily headaches, while men reported nausea, vomiting, abdominal pain and drowsiness (p < 0.001). Advanced research on Amanita muscaria should be carried out to make the community aware of the toxicity of this fungus. Full article
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