Special Issue "Advances in Organic Chemistry with Symmetry/Asymmetry"

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 45

Special Issue Editor

Dr. Sihua Hou
E-Mail Website
Guest Editor
School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Interests: asymmetric synthesis of bioactive natural products; scale synthesis of natural medication molecules; target molecule-oriented novel and efficient synthesis methodology research; development of novel anti-tumor, anti-inflammatory and immunomodulatory drug candidates
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Symmetry and asymmetry are important concepts in organic chemistry, especially when it comes to determining the stereochemistry and properties of organic molecules. Here are some advanced topics related to symmetry and asymmetry in organic chemistry:

  1. Chirality: Chirality is a property of a molecule that cannot be superimposed on its mirror image. Chiral molecules contain at least one chiral center or stereocenter, which is an atom that is connected to four different substituents. Chirality is often represented using Fischer projections or wedge-dash notation. The presence of chirality significantly influences the reactivity, properties, and biological activity of organic molecules;
  2. Enantiomers and diastereomers: Enantiomers are pairs of chiral molecules that are non-superimposable mirror images of each other. They have the same physical and chemical properties but rotate plane-polarized light in opposite directions (one is dextrorotatory, and the other is levorotatory). Diastereomers, on the other hand, are chiral molecules that are not mirror images of each other. They have different physical and chemical properties;
  3. Symmetry operations: Symmetry operations are transformations that leave a molecule unchanged. Examples of symmetry operations include rotation, reflection, inversion, and identity. The symmetry of a molecule can be determined by applying these operations and observing if the molecule remains unchanged throughout;
  4. Point group symmetry: Point group symmetry is a systematic way to describe the symmetry of a molecule using group theory. Point groups are classified based on the presence of symmetry elements, such as a principal axis of rotation, mirror planes, and inversion center. The point group of a molecule determines its physical properties, spectroscopic behavior, and reactivity;
  5. Stereoselectivity in reactions: The symmetry or asymmetry of a molecule can influence its reactivity and stereoselectivity in chemical reactions. For example, reactions with chiral substrates may lead to the formation of chiral products with specific stereochemical orientations. Understanding the symmetry of reaction intermediates and transition states can help predict the outcome of reactions and design selective synthetic methodologies;
  6. Crystallography and symmetry: Crystallography is a technique that utilizes X-ray diffraction to determine the arrangement of atoms in a crystal lattice. Symmetry plays a crucial role in crystallography as it allows for the determination of crystal structures and the identification of different crystallographic symmetries.

Overall, understanding symmetry and asymmetry in organic chemistry is essential for determining the stereochemistry and properties of organic molecules, predicting reaction outcomes, and designing new chemical reactions and synthetic pathways.

Dr. Sihua Hou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chirality
  • enantiomers and diastereomers
  • symmetry operations
  • point group symmetry
  • stereoselectivity in reactions
  • crystallography and symmetry

Published Papers

This special issue is now open for submission.
Back to TopTop