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Separations
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Determination of Pesticides and Drug Residues by Liquid Chromatography-Mass Spectrometry
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Determination of Pesticides and Drug Residues by Liquid Chromatography-Mass Spectrometry

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Chromatographic Separations".

Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 2881

Special Issue Editor

Dr. Andreia Freitas

E-Mail Website
Guest Editor
National Institute of Agricultural and Veterinary Research, Lisbon, Portugal
Interests: veterinary drug residues; pesticides residues; chromatography; mass spectrometry; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Food safety and the protection of consumers is assumed, today, to be one of the top priorities. Several worldwide entities are continuously revising legislation to ensure that the presence of undesirable contaminants in foodstuff is monitored and that the needed nutritional constituents are being valued. The need for constant control is due to the abusive use of certain pesticides in farms and veterinary medicines as growth promoters in animal production. To prevent the consequent health problems in humans and animals, the development of analytical methods for the determination of contaminant residues in food and feed is mandatory in food safety. To fulfill the specificity and selectivity criteria obligatory for an accurate detection, the use of chromatography coupled with mass spectrometry as the main analytical tool is necessary. Low-resolution mass spectrometry (LR-MS), as a coupled triple quadrupole, is the first choice in routine analysis and allows single determinations and multi-compound detection. The use of high-resolution mass spectrometry (HR-MS) in residue analysis has been increasing, offering the possibility of simultaneous analysis, without limitation in the number of compounds. Such techniques are also widely applied in the nutritional characterization of food products as a tool of choice.

Dr. Andreia Freitas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food safety
  • anthropogenic contaminants
  • natural contaminants
  • veterinary drug residues
  • chromatography
  • mass spectrometry
  • animal production
  • pesticides

Published Papers (2 papers)

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Research

15 pages, 945 KiB  
Article
Mycotoxins and Maize Value Chain: Multi-Matrix and Multi-Analyte Tools towards Global Feed and Food Safety
by Marta Leite, Andreia Freitas, Jorge Barbosa and Fernando Ramos
Separations 2023, 10(9), 486; https://doi.org/10.3390/separations10090486 - 05 Sep 2023
Cited by 1 | Viewed by 1054
Abstract
Maize value chains represent invaluable end-consumer products in food systems worldwide. Mycotoxin contamination along these chains causes severe economic and health impacts from the plant, animal and human safety points of view. This work aimed to develop a single standardized methodology that fulfilled [...] Read more.
Maize value chains represent invaluable end-consumer products in food systems worldwide. Mycotoxin contamination along these chains causes severe economic and health impacts from the plant, animal and human safety points of view. This work aimed to develop a single standardized methodology that fulfilled extraction and detection procedures for 22 mycotoxins in maize chain matrices. The main goal concerned the validation of a QuEChERS-based ultra-high-performance liquid chromatography coupled to the tandem mass spectrometry (UHPLC-MS/MS) method in compliance with established performance criteria for mycotoxin determination. Validation parameters encompassing specificity/selectivity, linearity, precision, recovery, Limits of Detection (LOD) and Limits of Quantification (LOQ) were evaluated, and acceptable data were found for all the mycotoxins in the matrices under study, namely, seeds, flowering plants, silage and feed. The applied method presented LODs and LOQs lower than 40.3 and 42.1 ng g−1, respectively, and recoveries ranging from 80.7 to 118.1%, with precision values below 20.5%. A first-time full analytical procedure in a multi-matrix and multi-analyte approach was successfully validated, representing a valuable control tool for mycotoxin monitoring in maize chains. This approach will ultimately allow a response to the need for integrated risk assessments encompassing full, comprehensive analysis of whole food chains in compliance with the maximum levels established in European regulations, and the establishment of accurate solutions in each chain-specific critical point, helping to provide more sustainable, safer and healthy food systems. Full article
(This article belongs to the Special Issue Determination of Pesticides and Drug Residues by Liquid Chromatography-Mass Spectrometry)
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18 pages, 1327 KiB  
Article
Rapid Multi-Residue Method for Simultaneous Determination of 1,3,5-Triazine Herbicides in Environmental Samples by Capillary GC-MS-EI Selective Ion Monitoring Method
by Perumal E. Ravi, Perumal E. Thirugnanam, Jothi Ramalingam Rajabathar, Hamad Al-Lohedan, S. Jenifer and Muthusamy Karnan
Separations 2023, 10(6), 363; https://doi.org/10.3390/separations10060363 - 18 Jun 2023
Viewed by 1334
Abstract
A new multi-residue method using gas chromatography–mass spectrometry electron ionization selective ion monitoring mode (SIM) has been developed for the simultaneous determination of eight 1,3,5-triazine herbicides such as 1,3,5-triazine-2,4-diamine (atrazine), ametryn, prometryn, propazine, terbuthylazine, terbutryn, and simazine simetryn in water and soil samples. [...] Read more.
A new multi-residue method using gas chromatography–mass spectrometry electron ionization selective ion monitoring mode (SIM) has been developed for the simultaneous determination of eight 1,3,5-triazine herbicides such as 1,3,5-triazine-2,4-diamine (atrazine), ametryn, prometryn, propazine, terbuthylazine, terbutryn, and simazine simetryn in water and soil samples. Quantification is done using lindane (gamma benzene hexachloride) as an internal standard. A specific Capillary DB-Wax column of 30 m length, 0.32 mm internal diameter, and 0.25 µm film thickness is used for the separation of eight 1,3,5-triazine-2,4-diamine. The method was applied for the determination of residues in groundwater and soil samples. The lowest detection limit by GC-MS-SIM (selective ion monitoring mode) is 0.1 pg/mL. Recovery in water samples is in the range of 93–103%, and in soil samples, 91–102% for different individual compounds. Forty-five groundwater and soil samples were collected in and around Kancheepuram district in Tamilnadu (India), and they were analyzed for the respective residues. A detailed discussion of the GC-MS analysis results has been presented. Full article
(This article belongs to the Special Issue Determination of Pesticides and Drug Residues by Liquid Chromatography-Mass Spectrometry)
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