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Separations
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Applications of Chromatography Technology
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Applications of Chromatography Technology

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Materials in Separation Science".

Deadline for manuscript submissions: closed (10 January 2023) | Viewed by 8646

Special Issue Editor

Dr. Chao Kang

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, China
Interests: analytical chemistry; multiway calibration; high-performance liquid chromatography; liquid chromatography–mass spectrometry; gas chromatography–mass spectrometry; metabolomics; image analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chromatography technologies, including high-performance liquid chromatography (HPLC), gas chromatography (GC), liquid chromatography–mass spectrometry (LC-MS), and gas chromatography–mass spectrometry (GC-MS), are powerful and generally applicable for the separation, identification, and determination of the chemical substances in complex mixtures. Chromatography can separate and detect a wide range of substances, from ions to compounds, from small molecules to biomolecules, from nonpolar to polar molecules, and from non-volatile to volatile substances.

The applications of chromatography have grown explosively in recent decades, due not only to the development of new types of chromatographic techniques but also to the growing need for characterizing complex mixtures. Chromatography has been a powerful and versatile tool for qualitative identification and quantitative determination in many fields such as biological analysis, pharmaceutical analysis, environmental analysis, food analysis, clinical analysis, metabolomics, and proteomics.

This Special Issue of Separations entitled “Applications of Chromatography Technology” will present the latest research and advancements. This Special Issue accepts research papers and critical reviews on all aspects of applications of chromatography.

Dr. Chao Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chromatography
  • HPLC
  • LC-MS
  • GC-MS
  • proteomics
  • metabolomics
  • complex mixtures
  • biological analysis
  • pharmaceutical analysis
  • environmental analysis

Published Papers (4 papers)

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Research

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15 pages, 2054 KiB  
Article
Research on the Removal of Levamisole Residues in Bovine, Ovine, Caprine, Porcine and Poultry Tissues
by Viviana Carmen Ciucă, Carmen Otilia Rusănescu and Victor Viorel Safta
Separations 2022, 9(9), 261; https://doi.org/10.3390/separations9090261 - 14 Sep 2022
Cited by 4 | Viewed by 1993
Abstract
In this paper, we set the waiting time for the elimination of levamisole residues at a safe level from tissues (muscles and organs) from animals treated with levamisole 10%—oral solution. We studied the depletion of levamisole residues by high performance liquid chromatography with [...] Read more.
In this paper, we set the waiting time for the elimination of levamisole residues at a safe level from tissues (muscles and organs) from animals treated with levamisole 10%—oral solution. We studied the depletion of levamisole residues by high performance liquid chromatography with a mass spectrometer (limit of quantification 2 μg/kg) in the tissues of bovine, ovine, caprine, porcine and poultry (chickens and pigeons) after administration of levamisole (10 mg levamisole/kg body weight for cattle, sheep, goats, pigs and 20 mg levamisole/kg body weight for birds). We found that in cattle, sheep and goats at 7 days after treatment, the residues of levamisole in the liver and at 14 days and in the other tissues were below the established limit value. In pigs at 7 days, residues from all tissues were below the set limit value. Residue depletion in chickens treated with levamisole was rapid, such that 3 days after treatment, the residues in all tissues were below the set limit. Residue depletion was slower in turkeys than in chickens. Full article
(This article belongs to the Special Issue Applications of Chromatography Technology)
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9 pages, 3343 KiB  
Article
Speciation of Selenium in Selenium-Enriched Foods by High-Performance Liquid Chromatography-Inductively Coupled Plasma-Tandem Mass Spectrometry
by Yue Luo, Gang Chen, Xiuqing Deng, Hanqing Cai, Xueheng Fu, Fujian Xu, Xiaonian Xiao, Yumeng Huo and Jin Luo
Separations 2022, 9(9), 242; https://doi.org/10.3390/separations9090242 - 3 Sep 2022
Cited by 8 | Viewed by 1971
Abstract
Herein, a method was established for the speciation of six selenium species by high performance liquid chromatography-inductively coupled plasma-tandem mass spectrometry (HPLC-ICP-MS/MS). The factors affecting separation were carefully investigated, including ionic strength, pH, and methanol content. Six species of selenium could be completely [...] Read more.
Herein, a method was established for the speciation of six selenium species by high performance liquid chromatography-inductively coupled plasma-tandem mass spectrometry (HPLC-ICP-MS/MS). The factors affecting separation were carefully investigated, including ionic strength, pH, and methanol content. Six species of selenium could be completely separated within 20 min, under the mobile phase of 25 mM citric acid in pH = 4.0 containing 2% methanol. The detection limits of selenite (Se(IV)), selenate (Se(VI)), selenomethionine (SeMet), selenocystine (SeCys2), methylselenocysteine (MeSeCys), and selenoethionine (SeEt) were 0.04, 0.02, 0.05, 0.02, 0.03, and 0.15 ng mL−1, respectively. To verify the practicality of this method, the analysis of selenium-enriched foods such as selenium-enriched spring water, selenium-enriched salts, and selenium-enriched tea were conducted, and recovery of 93.7–105% was achieved with RSD < 5%, revealing the high practical utility of the proposed method. Full article
(This article belongs to the Special Issue Applications of Chromatography Technology)
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15 pages, 1126 KiB  
Article
A Fast Method for the Simultaneous Analysis of 26 Beta-Agonists in Swine Muscle with a Multi-Functional Filter by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
by Lin Zhang, Qi Jia, Guangqin Liao, Yongzhong Qian and Jing Qiu
Separations 2022, 9(5), 121; https://doi.org/10.3390/separations9050121 - 13 May 2022
Cited by 7 | Viewed by 2099
Abstract
A rapid and simplified sample preparation method was developed for the simultaneous determination of 26 beta-agonists in swine muscle using a multi-functional filter (MFF) based on quick, easy, cheap, effective, rugged, and safe methods (QuEChERS). MFF integrated the cleanup and filter procedures, thereby [...] Read more.
A rapid and simplified sample preparation method was developed for the simultaneous determination of 26 beta-agonists in swine muscle using a multi-functional filter (MFF) based on quick, easy, cheap, effective, rugged, and safe methods (QuEChERS). MFF integrated the cleanup and filter procedures, thereby significantly improving the efficiency of sample preparation compared with traditional solid-phase extraction. The sample was processed via enzymatic hydrolysis, purified with the optimized MFF containing 150 mg magnesium sulfate, 50 mg PSA, and 50 mg C18, and then analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. All procedures can be completed in 6.5 h. Good linearity (R2 > 0.99) was detected in all analytes. The recoveries ranged from 71.2% to 118.6%, with relative standard deviations (RSDs) of less than 18.37% in all spiked concentrations. The limits of detection (LOD) and the limits of quantitation (LOQ) were 0.01–0.10 and 0.10–0.50 μg/kg, respectively. The decision limit (CCα) and detection capacity (CCβ) values fluctuated in the range of 3.44–25.71 and 6.38–51.21 μg/kg, respectively. This method is a good alternative for detecting beta-agonist residues in swine muscle and can be successfully applied to the national risk monitoring of agro-product quality and safety in China. Full article
(This article belongs to the Special Issue Applications of Chromatography Technology)
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Review

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17 pages, 1779 KiB  
Review
Application of Chromatographic Technology to Determine Aromatic Substances in Tobacco during Natural Fermentation: A Review
by Xuefeng Li, Jun Bin, Xiufang Yan, Mengjiao Ding and Min Yang
Separations 2022, 9(8), 187; https://doi.org/10.3390/separations9080187 - 23 Jul 2022
Cited by 1 | Viewed by 1909
Abstract
Flavor is an important index to evaluate the sensory quality of tobacco. The process of fermentation is a key step in the production of aromatic substances in tobacco leaves and an important factor in improving their quality. Worldwide, reams of research show that [...] Read more.
Flavor is an important index to evaluate the sensory quality of tobacco. The process of fermentation is a key step in the production of aromatic substances in tobacco leaves and an important factor in improving their quality. Worldwide, reams of research show that chromatographic technology plays an irreplaceable role in the tobacco aromatic chemistry. Nevertheless, the degradation mechanism of latent aromatic compounds and the formation mechanism of characteristic aromatic substances have not been fully and systematically elucidated. In this study, the latest progress of basic methods, techniques, and research results of the separation, analysis, and identification of aromatic substances in fermented tobacco leaves were reviewed, and the next research and application directions were prospected. It is expected to provide theoretical reference for the study of molecular mechanism of tobacco flavor, reveal the degradation mechanism of potential aroma compounds, and help improve the quality of tobacco. Full article
(This article belongs to the Special Issue Applications of Chromatography Technology)
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