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CMOS Sensors for Biomedical Monitoring and Diagnostics

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1258

Special Issue Editor


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Guest Editor
Department of Electrical Engineering and Computer Science, Nagoya University, Furo, Chikusa, Nagoya 464-8603, Aichi, Japan
Interests: CMOS integrated circuits; biosensors; biomedical electronics; sensor arrays; CMOS analogue integrated circuits; biofuel; low-power electronics; microsensors; network analysers; optical sensors; oscillators; patient diagnosis; temperature sensors; tumors; big data; digital CMOS

Special Issue Information

Dear Colleagues,

Advances in semiconductor technology have enabled the integration of more than ten billion transistors on a chip, following Moore’s Law, whereby the number of elements on a fixed silicon die doubles every 18 months. This makes it possible to fabricate structures at a 3 nm scale, which can detect and manipulate a single molecule. Current semiconductor technology is well-matched to the complexity of biological systems and their parallel nature. Furthermore, semiconductor technology has offered cheap and small—yet still advanced—systems. The CMOS (complementary metal oxide semiconductor) is the main part of current integrated circuits and has developed mainly in the field of information and communication. It is now finding novel applications in the field of healthcare and environmental monitoring, as well as new sensing technology, which has discovered new phenomena. This technology has been rapidly developed in association with new biological technology. The goal of this Special Issue is to confirm its present status and discuss future prospects.

Prof. Dr. Kazuo Nakazato
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Research

15 pages, 3632 KiB  
Article
Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer
by Yuri D. Ivanov, Kristina A. Malsagova, Kristina V. Goldaeva, Svetlana I. Kapustina, Tatyana O. Pleshakova, Vladimir P. Popov, Andrey F. Kozlov, Rafael A. Galiullin, Ivan D. Shumov, Dmitry V. Enikeev, Natalia V. Potoldykova, Vadim S. Ziborov, Oleg F. Petrov, Alexander Y. Dolgoborodov, Alexander V. Glukhov, Sergey V. Novikov, Victoria K. Grabezhova, Evgeniy S. Yushkov, Vladimir A. Konev, Oleg B. Kovalev and Alexander I. Archakovadd Show full author list remove Hide full author list
Sensors 2023, 23(17), 7527; https://doi.org/10.3390/s23177527 - 30 Aug 2023
Cited by 1 | Viewed by 901
Abstract
Prostate cancer (PC) is one of the major causes of death among elderly men. PC is often diagnosed later in progression due to asymptomatic early stages. Early detection of PC is thus crucial for effective PC treatment. The aim of this study is [...] Read more.
Prostate cancer (PC) is one of the major causes of death among elderly men. PC is often diagnosed later in progression due to asymptomatic early stages. Early detection of PC is thus crucial for effective PC treatment. The aim of this study is the simultaneous highly sensitive detection of a palette of PC-associated microRNAs (miRNAs) in human plasma samples. With this aim, a nanoribbon biosensor system based on “silicon-on-insulator” structures (SOI-NR biosensor) has been employed. In order to provide biospecific detection of the target miRNAs, the surface of individual nanoribbons has been sensitized with DNA oligonucleotide probes (oDNA probes) complementary to the target miRNAs. The lowest concentration of nucleic acids, detectable with our biosensor, has been found to be 1.1 × 10−17 M. The successful detection of target miRNAs, isolated from real plasma samples of PC patients, has also been demonstrated. We believe that the development of highly sensitive nanotechnology-based biosensors for the detection of PC markers is a step towards personalized medicine. Full article
(This article belongs to the Special Issue CMOS Sensors for Biomedical Monitoring and Diagnostics)
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