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Editorial Board Members' Collection Series: Aptamer Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 2526

Special Issue Editors


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Guest Editor
Grenoble Alpes University, CEA, CNRS, IRIG-SyMMES, 17 Rue des Martyrs, 38000 Grenoble, France
Interests: optoelectronic nose/tongue development; aptamer biosensors; surface plasmons resonance imaging; theory of microarrays (DNA or protein); biopolymer conformation; DNA based architectures; soft condensed matter
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, Slovakia
Interests: biosensors; DNA aptamers; electrochemistry; molecular acoustics; model membranes; nanomaterials; nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since the discovery of the SELEX method in the nineties, the emergence of aptamers as an interesting alternative to antibodies bloomed in the biosensors community. Their strong advantages as simple oligonucleotides have been widely documented: the in vitro selection of various targets from small molecules to whole cells, the ease of chemical synthesis and modifications, and the stability and cost to facilitate their integration in biosensors. Nonetheless, the number of commercial aptamer biosensors has not yet reached expectations.

This collection series on aptamer biosensors aims at setting the current state of the art in the domain and describing the remaining hurdles to reach the full potential of aptamers. To highlight only a few directions of research, we may mention:

  • The improvement in the selection method: diversity of targets and quality of aptamer characterization.
  • The modification of aptamer sequences for grafting on diverse surfaces or for improved performances and additional properties.
  • The integration in biosensors: diversity of transduction methods from electrochemical to optical and proximity to the end-user with point-of-care devices or wearable biosensors.
  • The applications of aptamer biosensors: from the diagnostics for health to the environment and quality control.

Dr. Arnaud Buhot 
Prof. Dr. Tibor Hianik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aptamers
  • biomarkers
  • selection
  • point-of-care
  • wearable sensors
  • diagnostics
  • health
  • environment
  • quality control

Published Papers (2 papers)

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Research

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12 pages, 4463 KiB  
Article
The High Stability and Selectivity of Electrochemical Sensor Using Low-Cost Diamond Nanoparticles for the Detection of Anti-Cancer Drug Flutamide in Environmental Samples
by Nareshkumar Baskaran, Sanjay Ballur Prasanna, Yu-Chien Lin, Yeh-Fang Duann, Ren-Jei Chung and Yang Wei
Sensors 2024, 24(3), 985; https://doi.org/10.3390/s24030985 - 02 Feb 2024
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Abstract
In this study, a novel electrochemical sensor was created by fabricating a screen-printed carbon electrode with diamond nanoparticles (DNPs/SPCE). The successful development of the sensor enabled the specific detection of the anti-cancer drug flutamide (FLT). The DNPs/SPCE demonstrated excellent conductivity, remarkable electrocatalytic activity, [...] Read more.
In this study, a novel electrochemical sensor was created by fabricating a screen-printed carbon electrode with diamond nanoparticles (DNPs/SPCE). The successful development of the sensor enabled the specific detection of the anti-cancer drug flutamide (FLT). The DNPs/SPCE demonstrated excellent conductivity, remarkable electrocatalytic activity, and swift electron transfer, all of which contribute to the advantageous monitoring of FLT. These qualities are critical for monitoring FLT levels in environmental samples. Various structural and morphological characterization techniques were employed to validate the formation of the DNPs. Remarkably, the electrochemical sensor demonstrated a wide linear response range (0.025 to 606.65 μM). Additionally, it showed a low limit of detection (0.023 μM) and high sensitivity (0.403 μA μM−1 cm−2). Furthermore, the practicability of DNPs/SPCE can be successfully employed in FLT monitoring in water bodies (pond water and river water samples) with satisfactory recoveries. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Aptamer Biosensors)
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Review

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31 pages, 5510 KiB  
Review
Paper-Based Aptasensors: Working Principles, Detection Modes, and Applications
by Anastasios Economou, Christos Kokkinos, Leda Bousiakou and Tibor Hianik
Sensors 2023, 23(18), 7786; https://doi.org/10.3390/s23187786 - 10 Sep 2023
Viewed by 1403
Abstract
Aptamers are short oligonucleotides designed to possess high binding affinity towards specific target compounds (ions, molecules, or cells). Due to their function and unique advantages, aptamers are considered viable alternatives to antibodies as biorecognition elements in bioassays and biosensors. On the other hand, [...] Read more.
Aptamers are short oligonucleotides designed to possess high binding affinity towards specific target compounds (ions, molecules, or cells). Due to their function and unique advantages, aptamers are considered viable alternatives to antibodies as biorecognition elements in bioassays and biosensors. On the other hand, paper-based devices (PADs) have emerged as a promising and powerful technology for the fabrication of low-cost analytical tools, mainly intended for on-site and point-of-care applications. The present work aims to provide a comprehensive overview of paper-based aptasensors. The review describes the fabrication methods and working principles of paper-based devices, the properties of aptamers as bioreceptors, the different modes of detection used in conjunction with aptasensing PADs, and representative applications for the detection of ions, small molecules, proteins, and cells. The future challenges and prospects of these devices are also discussed. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Aptamer Biosensors)
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