Nanosuspensions for Enhanced Oral Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 382
Special Issue Editors
Interests: nano/microparticle technologies - supercritical fluid technology, spray drying, spray freeze drying, jet-milling, high-pressure homogenization; dry powder inhalation (DPI) - pulmonary/nasal; drug delivery systems - SMEDDS, SNEDDS, micelle, liposome, liquid crystal; sustained release injectable preparation - PLGA microspheres, multivesicular liposomes; process analytical technology (PAT)
Special Issues, Collections and Topics in MDPI journals
Interests: sustained and controlled release formulation of drugs; quality by design; formulation and stabilization of emulsion, microemulsion and liposomes; solubilization techniques of poorly water-soluble drugs; polymorphism and cocrystal; coating and pelletization technology; targeted drug delivery system; microspheres and microcapsules; pharmacokinetics and bioequivalent study; drug stability; supercritical fluid technology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many drug candidates in the new drug development stage are included in the biopharmaceutical classification system (BCS) class II or IV; these have poor water solubility, which usually leads to low bioavailability. However, the development of nanosuspension technology has changed the paradigm of the past, where water-insoluble drugs were discarded, and accelerated research to breathe life into BCS class II and IV drugs that were kept in warehouses. Typically, nanosuspension formulation can result in the enhanced dissolution rate of poorly water-soluble drugs, hence improving the rate and extent of drug absorption and optimizing the bioavailability.
Several nanosuspension production technologies have been widely used to reduce drug particle size. The processes for nanosuspension are typically categorized into “top-down” and “bottom-up” methods. Top-down methods use mechanical comminution processes, including various dry/wet milling and high-pressure homogenization. In contrast, bottom-up methods are generally based on the particle precipitation processes such as spray drying, supercritical nanoparticle formation processes, and spray freeze drying. Moreover, novel techniques by combination of bottom-up and top-down were also introduced.
The aim of this Special Issue is to introduce recent developments and findings for all topics related to the nanosuspension. Thus, this Special Issue devotes mainly applied aspects, including application of novel bioactive materials to nanosuspension, the development of novel nanosuspension manufacturing technologies or formulations, the evaluation of biopharmaceutical performance for specialized administration routes, and physicochemical instability of nanosuspension and approaches to overcome it. Applicable bioactive materials are not limited to drugs, but may also include natural products with biological activity.
Prof. Dr. Heejun Park
Prof. Dr. Min-Soo Kim
Guest Editors
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Keywords
- nanosuspension
- nanodispersion
- nanocrystal
- top-down
- bottom-up
- stability
- solubility
- dissolution
- absorption
- bioavailability
