Application of Supercritical Fluid and Compressed Gas in Pharmaceutical Technology
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 6322
Special Issue Editors
Interests: solubilisation and stabilization; micro-nanoparticle; supercritical fluid technology; dry powder inhaler (DPI); solid dispersion; polymorphism; solid-state characterization; lipid based formulation; controlled release formulation; PLGA Microspheres; bioavailability
Special Issues, Collections and Topics in MDPI journals
Interests: sustained and controlled release formulation of drugs; quality by design; formulation and stabilization of emulsion, microemulsion and liposomes; solubilization techniques of poorly water-soluble drugs; polymorphism and cocrystal; coating and pelletization technology; targeted drug delivery system; microspheres and microcapsules; pharmacokinetics and bioequivalent study; drug stability; supercritical fluid technology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Supercritical fluids and compressed gases act as a solvent, antisolvent, solute, plasticizer, atomizing gas, and carrier fluid. Using these various mechanisms, supercritical fluids and compressed gases have been widely used in the application and development of various pharmaceutical processes, such as particle formation, atomization, mixing, drying, extraction, impregnation, melting, adsorption, milling, foaming, coating, extrusion, etc. Supercritical antisolvent, spray drying, fluid bed coating, and jet milling are typically included in these pharmaceutical processes. In addition, there have been promising advances in pharmaceutical technology using supercritical fluids and compressed gases through the application to various pharmaceutical drug delivery systems, such as solid dispersion, microsphere, dry powder inhaler, porous carrier, aerogel, and lipid-based formulations including solid lipid nanoparticle, nanostructured lipid carriers, and liposome. In recent years, some hybrid processes via a combination of supercritical fluids and compressed gases have also been introduced.
The aim of this Special Issue is to collect and introduce the recent developments and findings for all topics related to the application of supercritical fluid and compressed gas in pharmaceutical technology. Thus, this Special Issue devotes mainly applied aspects over the range from application in novel bioactive material to the development of novel pharmaceutical DDS and processes, using supercritical fluid and compressed gas. Applicable bioactive materials are not limited to drugs but may also include natural products having biological activity. A fundamental approach to explaining the applied results may also be included.
Dr. Heejun Park
Prof. Min-Soo Kim
Guest Editors
Manuscript Submission Information
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Keywords
- supercritical
- compressed gas
- solvent
- antisolvent
- solute
- atomization
- extraction
- drying
- drug delivery system
- pharmaceutical process
