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Special Issue "Metal-Based Prodrugs and Nanoparticles in Cancer Therapy"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: 10 August 2023 | Viewed by 3826
Special Issue Editors
Interests: metal homeostasis; ionophores; nanomedicine; theranostics; anticancer drugs
E-Mail Website1 Website2
2. Research Center on Nutraceuticals and Health Products (CERNUT), University of Catania, 95125 Catania, Italy
3. Molecular, Preclinical and Translational Imaging Research Centre (IMPRONTE), University of Catania, 95125 Catania, Italy
Interests: nutraceuticals; cancer biology; biomarkers; oxidative stress and natural compounds in cancer, aging, degenerative and metabolic disease; cancer epigenetics; DNA damage and comet assay; inflammation; nanosystem for drug delivery
Special Issues, Collections and Topics in MDPI journals
2.Gene Oncotherapy Sector, Institute of Molecular Genetics of National Research Centre "Kurchatov Institute", 123182 Moscow, Russia
Interests: cancer; gene therapy; immunotherapy; non-viral delivery; translational research; tumor microenvironment
Special Issue Information
In recent decades, the use of prodrugs and nanoparticles as drug delivery systems offers the possibility of developing sophisticated targeting therapeutics as powerful nanomedicine tools, enabling for biomedical applications in prevention, diagnosis, treatment of cancer disease, radiomics and theranostics. Transition metal complexes have been used in medicine to treat cancer for more than 40 years but many concerns are responsible for the current stall in the field of metal anticancer drugs. Nowadays, one of the strategies is to convert them into inert prodrugs, so that they can travel to the tumour site unchanged and release the drug in its active form only there. Moreover, the development of novel nanodrug delivery systems have been attracting growing interests as allow to improve pharmacokinetic and pharmacodynamic properties and show more therapeutic efficacy and less potential toxicity. In addition to nanostructures for delivering of known chemotherapeutic agents, the inclusion/combination of metal complex in/and nano-system may also be a reliable approach and the future for cancer therapy.
The present Special Issue of Pharmaceutics welcomes contributions dealing with all aspects of metallo-prodrugs and nanotechnology in drug delivery research, including
- synthetic methods for the realization of novel metallo-prodrugs, nanosystems and/or metallodrug in nanoparticles
- analysis of pharmacokinetic and pharmacodynamic properties of metal-based prodrugs, chemotherapeutics or metal drugs encapsulated in nanostructures
- in vitro or in vivo evaluation of therapeutic properties of metal-based prodrugs, nanoparticles and nanostructured materials functionalized with therapeutic metal complexes.
- Use of metal-pro drugs or/and nanoparticles in diagnosis, medical imaging, therapy and theranostics as well
We look forward to receiving your contributions.
Prof. Dr. Barbara Tomasello
Dr. Irina Naletova
Dr. Victor V. Pleshkan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cancer therapy
- clinical trials
- metal-based drugs
- metal complexes