Special Issue "Design, Development, and Application of Hydrogels for Cancer Treatment"
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2696
Interests: gastrointestinal cancer; biomarker; liquid biopsy; microRNA; 3D cell culture; 3D tumor model; epithelial to mesenchymal transition; chemoradiotherapy; response to therapy
A plethora of chemotherapeutics currently exist for the treatment of several human cancers. Although the essential first line treatment solution is efficient in some cancers, chemotherapeutics still cause tremendous side effects and induce resistance in different cancers. In recent years, engineering of nanomaterials has been constantly improving to overcome the toxicity of anticancer drugs. Researchers have developed complex in vitro models which better mimic the cancer microenvironment using different engineered nanomaterials. Hydrogels represent an innovative class of biomaterials with several applications to study complex mechanisms related to cancer behavior. The role of hydrogels in cancer therapy is emerging in recent years, and huge efforts have been devoted to developing and producing even more innovative hydrogel formulations, mimicking as closely as possible the pathophysiological conditions occurring in native cancer before or after treatment with chemotherapeutics. Moreover, hydrogels are often used as drug delivery systems but are still characterized by low biocompatibility, poor therapeutic potential, and high immunogenicity.
This Special Issue aims to collect contributions reporting on innovative approaches to design, produce, and characterize hydrogels as new potential therapeutics for cancer treatment. The issue will also be open to studies exploiting hydrogels as innovative models to deepen our understanding of cancer-related pathological and molecular mechanisms.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biomaterials engineering, drug discovery, cancer treatment, polymer science, nanomaterials, and materials chemistry.
I look forward to receiving your contributions.
Dr. Edoardo D'Angelo
Dr. Daniele Boso
Manuscript Submission Information
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- anticancer drugs
- 3D models
- cancer-related pathological and molecular mechanisms