Special Issue "Cell and Tissue-Based Formulations: from Design to Biomedical Applications"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 4846

Special Issue Editors

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain
Interests: topical dosage forms; drug delivery; transdermal and transmucosal route; micro- and nanoencapsulation; tissue engineering; cosmetics and dermopharmacy
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain
Interests: biomaterials; skin health; tissue engineering; cell therapy; legal regulatory aspect

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute to this Special Issue, entitled “Cell and Tissue-Based Formulations: from Design to Biomedical Applications”.

The use of cells and tissues as therapeutic agents have emerged over the past decades in order to offers new therapeutic alternatives to conventional approaches, giving an opportunity to treat pathologies that have not been cured yet. In this regard, numerous advances have been made, including innovative methodologies such as bio-printing for the manufacture of three-dimensional structures.  However, the poor delivery and viability of the cells is very limiting and this task represents an area of intensive research. Formulation excipients and biomaterials can limit the quality, safety and efficacy of the product. It is therefore important to understand the efforts of the scientific community to develop defined formulations and to discuss the ability of formulation excipients to increase product quality and recovery during administration. In addition, the administration of living cells and tissues, whether they are differentiated adult cells, stem cells and cell derivatives for  biomedical application requires to know their mechanism of action and how they behave in the formulated product. Therefore, this special issue aims to cover different aspects involved in the design and development of cell and tissue based formulations for biomedical applications, and will include articles focused on the design, fabrication and characterization of different formulations loaded with living cells and/or tissue, ranging from suspensions, hydrogels, scaffolds, constructs until bioinks, as well as its latest advances in research and clinical.

The final goal is to facilitate the knowledge and scientific innovations into cell and tissue-based formulations in order to be used for biomedical applications.

Dr. Beatriz Clares
Dr. Patricia Gálvez-Martín
Guest Editors

Manuscript Submission Information

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Published Papers (2 papers)

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Research

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Article
Combination of Hyaluronan and Lyophilized Progenitor Cell Derivatives: Stabilization of Functional Hydrogel Products for Therapeutic Management of Tendinous Tissue Disorders
Pharmaceutics 2021, 13(12), 2196; https://doi.org/10.3390/pharmaceutics13122196 - 19 Dec 2021
Cited by 7 | Viewed by 2471
Abstract
Cultured progenitor cells and derivatives have been used in various homologous applications of cutaneous and musculoskeletal regenerative medicine. Active pharmaceutical ingredients (API) in the form of progenitor cell derivatives such as lysates and lyophilizates were shown to retain function in controlled cellular models [...] Read more.
Cultured progenitor cells and derivatives have been used in various homologous applications of cutaneous and musculoskeletal regenerative medicine. Active pharmaceutical ingredients (API) in the form of progenitor cell derivatives such as lysates and lyophilizates were shown to retain function in controlled cellular models of wound repair. On the other hand, hyaluronan-based hydrogels are widely used as functional vehicles in therapeutic products for tendon tissue disorders. The aim of this study was the experimental characterization of formulations containing progenitor tenocyte-derived APIs and hyaluronan, for the assessment of ingredient compatibility and stability in view of eventual therapeutic applications in tendinopathies. Lyophilized APIs were determined to contain relatively low quantities of proteins and growth factors, while being physicochemically stable and possessing significant intrinsic antioxidant properties. Physical and rheological quantifications of the combination formulas were performed after hydrogen peroxide challenge, outlining significantly improved evolutive viscoelasticity values in accelerated degradation settings. Thus, potent effects of physicochemical protection or stability enhancement of hyaluronan by the incorporated APIs were observed. Finally, combination formulas were found to be easily injectable into ex vivo tendon tissues, confirming their compatibility with further translational clinical approaches. Overall, this study provides the technical bases for the development of progenitor tenocyte derivative-based injectable therapeutic products or devices, to potentially be applied in tendinous tissue disorders. Full article
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Review

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Review
The Role of Polymeric Biomaterials in the Treatment of Articular Osteoarthritis
Pharmaceutics 2022, 14(8), 1644; https://doi.org/10.3390/pharmaceutics14081644 - 06 Aug 2022
Cited by 2 | Viewed by 1793
Abstract
Osteoarthritis is a high-prevalence joint disease characterized by the degradation of cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self-repair, regenerative medicine strategies have become highly relevant in the management of osteoarthritis. Despite the great advances in medical [...] Read more.
Osteoarthritis is a high-prevalence joint disease characterized by the degradation of cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self-repair, regenerative medicine strategies have become highly relevant in the management of osteoarthritis. Despite the great advances in medical and pharmaceutical sciences, current therapies stay unfulfilled, due to the inability of cartilage to repair itself. Additionally, the multifactorial etiology of the disease, including endogenous genetic dysfunctions and exogenous factors in many cases, also limits the formation of new cartilage extracellular matrix or impairs the regular recruiting of chondroprogenitor cells. Hence, current strategies for osteoarthritis management involve not only analgesics, anti-inflammatory drugs, and/or viscosupplementation but also polymeric biomaterials that are able to drive native cells to heal and repair the damaged cartilage. This review updates the most relevant research on osteoarthritis management that employs polymeric biomaterials capable of restoring the viscoelastic properties of cartilage, reducing the symptomatology, and favoring adequate cartilage regeneration properties. Full article
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