Anticancer Nanomedicine: Recent Advances

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 2890

Special Issue Editor


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Guest Editor
Nano-Oncology and Translational Therapeutics Unit, Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital of Santiago de Compostela (CHUS), CIBERONC, 15706 Santiago de Compostela, Spain
Interests: nanomedicine; cancer; personalized Medicine

Special Issue Information

Dear Colleagues,

Cancer continues to be one of the main causes of death worldwide. A concerted effort in research is urgently needed to decrease the health and socioeconomic impact of cancer. Nowadays, it is known that nanomedicine can contribute to the development of advanced and more efficient therapeutics, helping to fight cancer by providing improved outcomes in terms of toxicity and overall survival. Recent advances regarding the role of the tumor microenvironment and the immune system in cancer progression and formation of metastasis have prompted the development of new nanomedicines specifically designed to target cell populations other than cancer cells, as well as the development of combinatory treatments to provide a holistic approach. In parallel, nanomedicine can contribute to the development of innovative diagnosis modalities for the early detection of cancer and follow-up, as well as more advanced nanotheranostics. This Special Issue aims to incorporate a summary of up-to-date articles to provide a comprehensive overview of the most recent advances in cancer nanomedicine.

Dr. Maria De La Fuente
Guest Editor

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Keywords

  • cancer
  • metastasis
  • tumor microenvironment
  • personalized medicine
  • nanomedicine
  • nanotheranostics
  • diagnostics
  • immunotherapies
  • advanced therapies
  • combinatory therapies

Published Papers (1 paper)

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Research

13 pages, 4056 KiB  
Article
Supramolecular Caffeic Acid and Bortezomib Nanomedicine: Prodrug Inducing Reactive Oxygen Species and Inhibiting Cancer Cell Survival
by Ludwig Erik Aguilar, Se Rim Jang, Chan Hee Park and Kang Min Lee
Pharmaceutics 2020, 12(11), 1082; https://doi.org/10.3390/pharmaceutics12111082 - 11 Nov 2020
Cited by 10 | Viewed by 2486
Abstract
Phenolics from plant materials have garnered attention in nanomedicine research, due to their various medicinal properties. Caffeic acid, a phenolic compound that is abundant in coffee beans, has been proven to have anticancer effects, due to its reactive oxygen species (ROS)-inducing properties. Here, [...] Read more.
Phenolics from plant materials have garnered attention in nanomedicine research, due to their various medicinal properties. Caffeic acid, a phenolic compound that is abundant in coffee beans, has been proven to have anticancer effects, due to its reactive oxygen species (ROS)-inducing properties. Here, a supramolecular nanomedicine was designed using caffeic acid molecule and the synthetic anticancer drug bortezomib, via catechol–boronic acid conjugation and Fe(III) ion crosslinking. Bortezomib is a proteasome-inhibiting drug and its boronic acid functional group can bind to caffeic acid’s catechol moiety. By having a nanoparticle formulation that can deliver bortezomib via intracellular endocytosis, the catechol–boronic acid conjugation can be dissociated, which liberates the boronic acid functional group to bind to the 26S proteasome of the cell. The ROS-inducing property of caffeic acid also complements the bortezomib payload, as the latter suppresses the survival mechanism of the cell through NF-κB inhibition. Full article
(This article belongs to the Special Issue Anticancer Nanomedicine: Recent Advances)
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