Further Research in Polyphenols Formulations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 870

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Guest Editor
Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: cosmetology; cannabis sativa; herbal medicine; natural and non-natural non-opioid topical pain relievers; pharmaceutical technology

Special Issue Information

Dear Colleagues,

The main flavonoid sources are fruits and vegetables, and they are also abundant in cocoa products (cocoa powder, chocolate), black and green tea and red wine. Among the fruits (berries, plums, cherries, and apples) are the richest in flavonoids, whereas tropical fruits are poor in flavonoids. Polyphenols are biologically active compounds found in a wide range of plant materials and are used in various pharmaceutical and cosmetic formulations. These compounds have various pharmacological effects, including antioxidant, anti-inflammatory, cognitive enhancement, anti-migraine and anti-cancer effects. Numerous studies have shown their strong positive activities in reducing inflammation, modulating immune response, and supporting and restoring the normal functions of cells.

It is important to find methods to isolate phenolic compounds and to use them to produce or improve innovative pharmaceutical forms. Traditional methods such as maceration, percolation, recolonization, etc., are used for the extraction of phenolic compounds. In this Special Issue, we expect to see not traditional, but innovative extraction methods for polyphenols.

It is also paramount to find methods to ensure the bioavailability and efficiency of phenolic compounds. This is usually ensured by various technological procedures. We therefore look forward to innovative technologies and possible new pharmacological effects of polyphenols for the future of pharmaceuticals.

Prof. Dr. Jurga Bernatoniene
Guest Editor

Manuscript Submission Information

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Keywords

  • polyphenols
  • bioavailability
  • polyphenol activity
  • pharmaceuticals
  • cosmeceuticals
  • extraction
  • encapsulation
  • 3D printing
  • innovative drug formulations
  • targeted drug delivery

Published Papers (1 paper)

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21 pages, 2513 KiB  
Article
Impact of Polyvinylpyrrolidone-Vinyl Acetate Copolymer and Sodium Starch Glycolate Excipients on Phenolic Extraction from Red Clover: Enhancing Biological Activity and Antioxidant Potential
by Jurga Andreja Kazlauskaite, Mindaugas Marksa and Jurga Bernatoniene
Pharmaceutics 2024, 16(3), 399; https://doi.org/10.3390/pharmaceutics16030399 - 14 Mar 2024
Viewed by 592
Abstract
Adding certain excipients during the extraction process can enhance the concentration of target compounds, leading to potentially increased biological properties of the plant extract. This study explores the impact of PVP/VAC and SSG excipients on red clover bud extracts, aiming to enhance their [...] Read more.
Adding certain excipients during the extraction process can enhance the concentration of target compounds, leading to potentially increased biological properties of the plant extract. This study explores the impact of PVP/VAC and SSG excipients on red clover bud extracts, aiming to enhance their concentration of target compounds and, consequently, their biological properties. The antioxidative potential was evaluated using DPPH, ABTS, and FRAP methods, and the chemical profile was determined using mass spectrometry. Antibacterial activity against various strains was determined through the minimal inhibitory concentration (MIC) method. The results revealed that the excipient-enriched samples exhibited significantly elevated antioxidant activities as well as phenolic and flavonoid contents compared to control samples. Notably, sample V1E3 demonstrated the highest antioxidant potential, with 52.48 ± 0.24 mg GAE/g dw (phenolic content), 463 ± 6.46 μg TE/g dw (ABTS), 12.81 ± 0.05 μg TE/g dw (DPPH), and 29.04 ± 1.16 mg TE/g dw (post-column ABTS). The highest flavonoid content was found in the S1E3 sample—24.25 ± 0.17 mg RU/g dw. Despite the increased antioxidant potential, no significant variance in antimicrobial activity was noted between the test samples and controls. This implies that excipients may hold the potential to enhance the biological properties of red clover extracts for pharmaceutical applications. These findings contribute valuable insights into optimizing extraction processes for improved functionality and application of plant-derived compounds in therapeutic formulations. Full article
(This article belongs to the Special Issue Further Research in Polyphenols Formulations)
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