Emerging Technologies to Improve the Solubility of Poorly Soluble Drugs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 10 October 2024 | Viewed by 150
Special Issue Editors
Interests: solubility; dissolution; lipophilicity; acidity; permeability; biomimetic chromatography; high-throughput methodology
Special Issue Information
Dear Colleagues,
Advances in drug development technologies have led to complex chemical entities that, in most cases, have poor aqueous solubility and, consequently, poor bioavailability and efficacy. Solubility is, therefore, one of the main challenges that scientists face in the drug discovery process. This is why the development of strategies aimed at enhancing the solubility and dissolution of poor-soluble compounds has increased in recent years. Some of these approaches are focused on the chemical modification of drugs, others on physical changes, and strategies based on the use of excipients and carriers have also been explored.
This Special Issue aims to provide an overview of the recent advances in drug solubility enhancement strategies. Research areas may include (but are not limited to) the following: solid dispersions; micellization; particle size modification; the stabilization of supersaturated solutions; complexation; salt formation; and crystallization strategies. In this Special Issue, original research articles and reviews are welcome.
We look forward to receiving your contributions.
Prof. Dr. Elisabet Fuguet
Prof. Dr. Clara Ràfols
Guest Editors
Manuscript Submission Information
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Keywords
- solubility
- solid dispersions
- particle size
- complexation
- micellization
- salt formation
- crystallization
- supersaturation
