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6.9
5.4
Journals
Pharmaceutics
Special Issues
Advanced Pediatric Drug Formulation Strategies
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Advanced Pediatric Drug Formulation Strategies

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1453

Special Issue Editors

Prof. Dr. Lee-Yong Lim

E-Mail Website
Guest Editor
Pharmacy, School of Allied Health, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
Interests: taste-masked medicinal formulations; taste assessment; paediatric formulations; veterinary formulations
Dr. Okhee Yoo

E-Mail Website
Guest Editor
1. Pharmacy, School of Allied Health, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
2. Telethon Kids Institute, Perth Children's Hospital, 5 Hospital Ave, Nedlands, WA 6009, Australia
Interests: paediatric formulation; population pharmacokinetics; design of experiments

Special Issue Information

Dear Colleagues,

Regulatory, consumer and clinician advocacy for the development of age-appropriate medicines for the pediatric population has resulted in significant progress in the last decade. Strategies such as the application of peroral minitablets and microparticles are regarded as highly promising in offering dose flexibility and swallowability for young children. Several taste-masking platforms have also been developed for bitter-tasting drugs and have been clinically demonstrated to be more acceptable to the pediatric population than standard treatment options. More recently, advanced formulation strategies such as 3D printing and nanotechnology have emerged to address the medication needs of the diverse pediatric population.

The aim of this Special Issue of Pharmaceutics is to highlight new pediatric formulation strategies that address the issues of dose flexibility, swallowability, palatability, and the diverse physiological developmental stages encountered in the pediatric population. We invite researchers to publish their original research or review articles addressing novel taste-masking technology, 3D printing technology, nanotechnology, PK-informed personalized medicines, non-oral formulations, and AI-driven formulation strategies that are applied to the development of medicinal formulations for the pediatric population.

Prof. Dr. Lee-Yong Lim
Dr. Okhee Yoo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • paediatric/pediatric
  • taste masking
  • 3D printing
  • nanotechnology
  • PK-informed personalized medicines
  • non-oral pediatric formulations
  • AI-directed pediatric formulations

Published Papers (1 paper)

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Research

21 pages, 3060 KiB  
Article
Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric Use
by Blanca Chiclana-Rodríguez, Encarnacion Garcia-Montoya, Miquel Romero-Obon, Khadija Rouaz-El-Hajoui, Anna Nardi-Ricart, Marc Suñé-Pou, Josep M. Suñé-Negre and Pilar Pérez-Lozano
Pharmaceutics 2024, 16(1), 30; https://doi.org/10.3390/pharmaceutics16010030 - 25 Dec 2023
Viewed by 1181
Abstract
Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its development is necessary. Palatability (appreciation of smell, taste, and aftertaste) is [...] Read more.
Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its development is necessary. Palatability (appreciation of smell, taste, and aftertaste) is a key aspect to be considered during the development of pediatric formulations since only formulations with good palatability also have adequate acceptability in this population. Consequently, the aim of this research was to assess the palatability and acceptability of different CARV formulations using an in vivo taste assessment (ID Number PR103/22) in order to select the highest palatability-rated CARV formulation. The preparation of CARV formulations was based on a reference 1 mg/mL CARV solution, which contains malic acid as a solubilizing agent. Subsequently, sucralose and flavoring agents were added and mixed until complete dissolution to the corresponding formulations. Adult volunteers participated in this study and evaluated the taste and odor of various CARV formulations through a questionnaire and a sensory test. The mean palatability score, measured on a 10-point scale, increased from 1.60 for the unflavored control to 7.65 for the highest-rated flavored formulation. Moreover, the bitterness of the optimized CARV formulation was reduced from 66.67% to 17.86%, and the taste pleasantness was increased from 25/100 to 73/100. This optimized CARV formulation contains a sweetening agent, sucralose, in addition to two flavoring agents at appropriate concentrations for pediatrics. Furthermore, the physicochemical and microbiological stability of the optimized CARV formulation were evaluated for 6 months at 25, 30, and 40 °C, in addition to in-use stability for 15 days at 25 °C, whose results were confirmed. Thus, we successfully developed a palatable CARV liquid solution that contains excipients appropriate for pediatrics and is stable under the studied conditions. Full article
(This article belongs to the Special Issue Advanced Pediatric Drug Formulation Strategies)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Numerical modeling of microparticle inhalation in a realistic mouth-throat airway with pediatric tonsil hypertrophy: A virtual comparative analysis between pre- and post-operative models
Author: Yang
Highlights: •This study numerically investigates the impact of tonsillar hypertrophy-induced oropharyngeal airway obstruction on the transport and deposition of inhaled corticosteroids in the airways. •For the first time, a study was conducted on the establishment of pre- and post-operative mouth–throat airway models by virtual surgery •After removing oropharyngeal obstruction, a significant reduction in airway resistance was observed.

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