Novel Biomarkers and Drug Targets for Cancer Immunotherapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 1574

Special Issue Editors


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Guest Editor
1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
2. Pittsburgh Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: trauma immunology; molecular diagnostics and biomarkers; drug development

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Guest Editor
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, The University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Interests: stem cells; premalignancy; disease modeling; drug discovery; nanotechnology; lung cancer; immuno-oncology
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Special Issue Information

Dear Colleagues,

Cancer immunotherapy has revolutionized cancer treatment, providing remarkable advancements in patient outcomes. For this Special Issue, "Novel Biomarkers and Drug Targets for Cancer Immunotherapy", we welcome the submission of papers that explore cutting-edge research in cancer immunology and cell biology, which may be of use for the development of next-generation immunotherapy drugs, cell-based targeting, delivery systems targeting the tumor microenvironment, new biomarkers in cancer theranostics and diagnosis, etc.

This Special Issue delves into the discovery and validation of novel biomarkers with predictive and prognostic significance, elucidating their potential role in guiding precision cancer immunotherapy. Moreover, these articles highlight the identification and characterization of new drug targets, unveiling opportunities for therapeutic interventions that augment immune responses against tumors. Research or reviews are welcome on novel biomarkers, drug targets (such as new molecular targets, synthetic approaches, or optimized drug loading methods) for immunotherapeutic drugs, as well as the original anti-cancer mechanisms based on immunomodulatory and targeting therapy.

The papers featured in this Special Issue will underscore the critical need for personalized cancer immunotherapies, emphasizing the utilization of immune profiling and biomarker-based approaches for patient stratification. We anticipate that these findings will advance the field, opening new frontiers in cancer immunotherapy for the benefit of patients worldwide.

We look forward to receiving your contributions.

Dr. Upendra K. Kar
Dr. Manash Paul
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer immunotherapy
  • novel biomarkers
  • drug targets
  • precision medicine
  • immune profiling
  • immunomodulators
  • tumor microenvironment
  • therapeutic interventions
  • nanomedicine-based immunotherapy
  • immunotherapeutic drugs
  • personalized therapy
  • prognostic significance
  • predictive markers

Published Papers (1 paper)

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Review

15 pages, 1326 KiB  
Review
CRISPR/Cas9-Mediated Customizing Strategies for Adoptive T-Cell Therapy
by Hyeseon Park, Yoo Kyung Kang and Gayong Shim
Pharmaceutics 2024, 16(3), 346; https://doi.org/10.3390/pharmaceutics16030346 - 01 Mar 2024
Viewed by 1307
Abstract
Clustered regularly interspaced short palindromic repeat-associated protein Cas9 (CRISPR/Cas9) technology is at the forefront of cancer immunotherapy innovation, offering precise and personalized treatment strategies. In this review, we discuss CRISPR/Cas9’s ability to precisely edit the genome, its impact on immune checkpoint control, and [...] Read more.
Clustered regularly interspaced short palindromic repeat-associated protein Cas9 (CRISPR/Cas9) technology is at the forefront of cancer immunotherapy innovation, offering precise and personalized treatment strategies. In this review, we discuss CRISPR/Cas9’s ability to precisely edit the genome, its impact on immune checkpoint control, and its application in immune cell engineering, where it surpasses traditional gene editing techniques. Originally inspired by bacterial defense mechanisms, this technology has made great strides in cancer immunotherapy as a mechanism to specifically target the PD-1/PD-L1 pathway in immune checkpoint blockades. In addition, CRISPR/Cas9 plays an important role in cancer treatment by facilitating genetic modifications to enhance the properties of adoptive cell therapy, optimizing the therapeutic potential of this approach. This review provides an overview of the development of CRISPR/Cas9, its important role in immune checkpoint control, applications in immune cell engineering, and the current status of clinical trials. However, safety concerns related to off-target effects and unintended mutations require continued research and caution. Continued advances in CRISPR technology hold the promise of revolutionizing the cancer treatment paradigm, providing personalized and effective therapies for patients with various types of cancer. Full article
(This article belongs to the Special Issue Novel Biomarkers and Drug Targets for Cancer Immunotherapy)
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