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Pharmaceutics
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Antitumor Activity of Silver Nanoparticles and Its Implications on Global...
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Antitumor Activity of Silver Nanoparticles and Its Implications on Global Health

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 3991

Special Issue Editors

Dr. Yanis Toledano-Magaña

E-Mail Website
Guest Editor
Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Blvd. Zertuche y Blvd., De los Lagos S/N Fracc, Valle Dorado, Ensenada 22890, Baja California, Mexico
Interests: nanotoxicology; nanomedicine; cancer; drug development
Special Issues, Collections and Topics in MDPI journals
Dr. Juan Carlos García-Ramos

E-Mail Website
Guest Editor
Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Blvd. Zertuche y Blvd., De los Lagos S/N Fracc, Valle Dorado, Ensenada 22890, Baja California, Mexico
Interests: metal-based drugs; cancer; nanomaterials; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Silver nanoparticles are among the most studied particles due to their biomedical properties in regard to cancer treatment. Several research groups have worked on determining the potential application of silver nanoparticles, their relationship with their physicochemical properties, and their possible adverse effects, among other things, in order to arrive at an alternative treatment as a viable solution for cancer. However, the international scientific community is still concerned about finding the most effective and efficient methods to establish clear cost/benefit ratios. In addition, the regulations regarding the use of silver nanoparticles for biomedical treatment are still under development, which poses a greater challenge.

This Special Issue highlights the research and development of silver nanoparticles with a focus on cancer treatment. It contemplates in vivo, in vitro, and in silico models to evaluate effectiveness as well as toxicity, genotoxicity, and teratogenicity, which contribute to the knowledge of the antitumor activity of silver nanoparticles and its implications in global health.

Dr. Yanis Toledano-Magaña
Dr. Juan Carlos García-Ramos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • silver nanoparticles
  • antitumor activity
  • cytotoxicity
  • genotoxicity
  • in silico approaches
  • normativity and guidelines

Published Papers (2 papers)

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Research

20 pages, 2912 KiB  
Article
A Comparative Study of Cancer Cells Susceptibility to Silver Nanoparticles Produced by Electron Beam
by Evgenii V. Plotnikov, Maria S. Tretayakova, Diana Garibo-Ruíz, Ana G. Rodríguez-Hernández, Alexey N. Pestryakov, Yanis Toledano-Magaña and Nina Bogdanchikova
Pharmaceutics 2023, 15(3), 962; https://doi.org/10.3390/pharmaceutics15030962 - 16 Mar 2023
Cited by 1 | Viewed by 2043
Abstract
Introduction: Silver nanoparticles (AgNPs) have a wide range of bioactivity, which is highly dependent on particle size, shape, stabilizer, and production method. Here, we present the results of studies of AgNPs cytotoxic properties obtained by irradiation treatment of silver nitrate solution and various [...] Read more.
Introduction: Silver nanoparticles (AgNPs) have a wide range of bioactivity, which is highly dependent on particle size, shape, stabilizer, and production method. Here, we present the results of studies of AgNPs cytotoxic properties obtained by irradiation treatment of silver nitrate solution and various stabilizers by accelerating electron beam in a liquid medium. Methods: The results of studies of morphological characteristics of silver nanoparticles were obtained by transmission electron microscopy, UV-vis spectroscopy, and dynamic light scattering measurements. MTT test, alamar blue test, flow cytometry, and fluorescence microscopy were used to study the anti-cancer properties. As biological objects for standard tests, adhesive and suspension cell cultures of normal and tumor origin, including prostate cancer, ovarian cancer, breast cancer, colon cancer, neuroblastoma, and leukemia, were studied. Results: The results showed that the silver nanoparticles obtained by irradiation with polyvinylpyrrolidone and collagen hydrolysate are stable in solutions. Samples with different stabilizers were characterized by a wide average size distribution from 2 to 50 nm and low zeta potential from −7.3 to +12.4 mV. All AgNPs formulations showed a dose-dependent cytotoxic effect on tumor cells. It has been established that the particles obtained with the combination of polyvinylpyrrolidone/collagen hydrolysate have a relatively more pronounced cytotoxic effect in comparison to samples stabilized with only collagen or only polyvinylpyrrolidone. The minimum inhibitory concentrations for nanoparticles were less than 1 μg/mL for various types of tumor cells. It was found that neuroblastoma (SH-SY5Y) is the most susceptible, and ovarian cancer (SKOV-3) is the most resistant to the action of silver nanoparticles. The activity of the AgNPs formulation prepared with a mixture of PVP and PH studied in this work was higher that activity of other AgNPs formulations reported in the literature by about 50 times. Conclusions: The results indicate that the AgNPs formulations synthesized with an electron beam and stabilized with polyvinylpyrrolidone and protein hydrolysate deserve deep study for their further use in selective cancer treatment without harming healthy cells in the patient organism. Full article
(This article belongs to the Special Issue Antitumor Activity of Silver Nanoparticles and Its Implications on Global Health)
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19 pages, 6966 KiB  
Article
Phytochemical-Stabilized Platinum-Decorated Silver Nanocubes INHIBIT Adenocarcinoma Cells and Enhance Antioxidant Effects by Promoting Apoptosis via Cell Cycle Arrest
by Adewale Odunayo Oladipo, Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo and Titus Alfred Makudali Msagati
Pharmaceutics 2022, 14(11), 2541; https://doi.org/10.3390/pharmaceutics14112541 - 21 Nov 2022
Cited by 5 | Viewed by 1487
Abstract
(1) Background: The increasing use of silver and platinum bimetallic nanoparticles in the diagnosis and treatment of cancer presents significant advances in biomedical applications due to their extraordinary physicochemical properties. This study investigated the role of aqueous phytochemical extract in stabilizing platinum nanodots-decorated [...] Read more.
(1) Background: The increasing use of silver and platinum bimetallic nanoparticles in the diagnosis and treatment of cancer presents significant advances in biomedical applications due to their extraordinary physicochemical properties. This study investigated the role of aqueous phytochemical extract in stabilizing platinum nanodots-decorated silver nanocubes (w-Pt@AgNPs) for enhancing antioxidant activities and their mechanism. (2) Methods: UV-Vis, Fourier transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM) were used to characterize the formed w-Pt@AgNPs. LC-QToF-MS/MS was used to analyze the bioactive compounds, while DPPH, ABTS, and FRAP were used to detect the scavenging potential. Flow cytometric assays were performed to investigate the cytotoxicity and the mechanism of cell death. (3) Results: Morphological studies indicated that w-Pt@AgNPs were cube in shape, decorated by platinum nanodots on the surfaces. Compared to ethanolic extract-synthesized e-Pt@AgNPs, w-Pt@AgNPs exhibited the strongest antioxidant and cytotoxic activity, as data from Annexin V and Dead cell labeling indicated higher induction of apoptosis. Despite the high proportion of early apoptotic cells, the w-Pt@AgNPs triggered a decrease in G1/G0 cell cycle phase distribution, thereby initiating a G2/M arrest. (4) Conclusions: By enhancing the antioxidant properties and promoting apoptosis, w-Pt@AgNPs exhibited remarkable potential for improved cancer therapy outcomes. Full article
(This article belongs to the Special Issue Antitumor Activity of Silver Nanoparticles and Its Implications on Global Health)
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