Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Recent Advances in Oral Pharmaceutical Forms
share announcement

Recent Advances in Oral Pharmaceutical Forms

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1814

Special Issue Editors

Prof. Dr. ‪Dumitru Lupuliasa

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: pharmaceutical forms manufacturing; drug preformulation and formulation; drug release; biopharmaceutical charcterization
Special Issues, Collections and Topics in MDPI journals
Dr. Anca Lucia Pop

E-Mail Website1 Website2
Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: nutritional evaluation; nutritional biomarkers; practical nutrition; metabolic disease; diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Emma Adriana Ozon

E-Mail Website1 Website2
Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: drug design; development, optimization, and manufacturing of pharmaceutical products; pre- and post-compression parameters for solid dosage forms; preformulating studies on pharmaceuticals; physico-chemical characterization of materials; cyclodextrin inclusion complexes; drug delivery systems; pharmaceutical processes; drug release profiles; quality of pharmaceutical forms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Worldwide, Oral pharmaceutical forms, ranging from conventional to innovative systems, are the most utilized pharmaceutical forms. Due to their increased adherence among patients, Oral pharmaceutical forms are at the center of multiple types of research, being the most studied pharmaceutical products. As pharmaceutical technology is continuously progressing through the development of new excipients and new manufacturing techniques, further studies should be performed to improve the actual state of the drug market. In all stages of the oral forms development process, many factors should be considered, and several challenges must be addressed. Through the appropriate optimization of the preformulation, formulation and manufacturing processes of Oral pharmaceutical forms, many limitations, such as poor drug stability, release, or bioavailability, can be overcome. Oral pharmaceutical forms include a great variety of formulations, and it is essential to establish a suitable system for each active ingredient as a function of its behavior and physicochemical properties, in order to achieve the high performance of the final product.

Prof. Dr. ‪Dumitru Lupuliasa
Dr. Anca Lucia Pop
Dr. Emma Adriana Ozon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • preformulation studies
  • oral solid dosages development
  • pharmaceutical formulation
  • food supplements formulation
  • direct compression
  • tablets
  • oral powders
  • hot-melt extrusion
  • 3D drug manufacturing
  • oral nano pharmaceuticals
  • solid dosages stability
  • release kinetics
  • kinetics and pharmacodynamics in oral forms
  • oral and gastrointestinal absorption barrier in oral forms
  • the influence of the oral and gastrointestinal microbiota on oral pharmaceutical forms
  • oral pharmaceutical forms
  • enhanced bioavailability

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

18 pages, 9364 KiB  
Article
Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties
by Gyula Farkas, Sándor Nagy, Attila Dévay, Aleksandar Széchenyi and Szilárd Pál
Pharmaceutics 2024, 16(3), 405; https://doi.org/10.3390/pharmaceutics16030405 - 15 Mar 2024
Viewed by 737
Abstract
The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have [...] Read more.
The flow properties of pellets or granules are crucial for further processing drug dosage forms. Optimal compression or filling of multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques have been developed to examine flowability, including static and dynamic methods applying empirical studies and up-to-date chaos theory; however, the newest methods seem only to be powerful with the supplementation of empirical principles. Our experiments try to refine both the technique of analysis and the methods, by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model that combined empirical observations and chaos theory on a geometrical basis, thus finding new characteristics regarding the flow properties of pellets and granules that could be relevant for drug developers. Our findings indicate that sphericity and particle size are the most significant factors influencing the flowability of pharmaceutical multiparticular preparations. Furthermore, this study confirms that integrating chaos theory and empirical observations in a time-dependent dynamic model provides a comprehensive understanding of particle flow behavior, pivotal for optimizing manufacturing processes. Full article
(This article belongs to the Special Issue Recent Advances in Oral Pharmaceutical Forms)
►▼ Show Figures

Figure 1

14 pages, 1875 KiB  
Article
In Vitro and In Vivo Evaluation of Magnetic Floating Dosage Form by Alternating Current Biosusceptometry
by Gustavo Serafim Rodrigues, João Miguel Barboza, Laís Pereira Buranello, Vitor Melo Brandão, Priscileila Colerato Ferrari, Guilherme Augusto Soares and José Ricardo de Arruda Miranda
Pharmaceutics 2024, 16(3), 351; https://doi.org/10.3390/pharmaceutics16030351 - 02 Mar 2024
Viewed by 764
Abstract
Floating controlled systems seek to extend the gastric retention time (GRT) of solid pharmaceutical forms by sustaining buoyancy in the stomach without affecting gastric emptying rates. This investigation aimed to evaluate a magnetic floating drug delivery system (MFDDS) under diverse physiological conditions (pressure [...] Read more.
Floating controlled systems seek to extend the gastric retention time (GRT) of solid pharmaceutical forms by sustaining buoyancy in the stomach without affecting gastric emptying rates. This investigation aimed to evaluate a magnetic floating drug delivery system (MFDDS) under diverse physiological conditions (pressure and viscosity) using an Alternating Current Biosusceptometry (ACB) system by conducting assessments in vitro and in vivo. For in vitro experiments, MFDDSs were placed under different pressures (760, 910, and 1060 mmHg) and viscosities (1, 50, 120, and 320 mPa·s) for evaluation of floating lag time (FLT). For in vivo experiments, eight healthy volunteers participated in two phases (fasting and fed) for gastric parameters (GRT, FLT, and OCTT—orocaecal transit time) assessment, employing the ACB system. The results indicated that pressure, viscosity, and FLT were directly proportional in the in vitro assay; in addition, increases in the OCTT (fasting = 241.9 ± 18.7; fed = 300 ± 46.4), GRT (fasting = 139.4 ± 25.3; fed = 190.2 ± 47.7), and FLT (fasting = 73.1 ± 16.9; fed = 107.5 ± 29.8) were detected in vivo. Our study emphasizes that the ACB system is a valuable technique, and it is capable of tracking and imaging MFDDS in in vitro and in vivo experiments. Full article
(This article belongs to the Special Issue Recent Advances in Oral Pharmaceutical Forms)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Dear Colleagues,

Worldwide, oral solid dosages, ranging from conventional to innovative systems, are the most utilized pharmaceutical forms. Due to their increased adherence among patients, oral solid dosages are at the center of multiple types of research, being the most studied pharmaceutical products. As pharmaceutical technology is continuously progressing through the development of new excipients and new manufacturing techniques, further studies should be performed to improve the actual state of the drug market. In all stages of the solid dosage development process, many factors should be considered, and several challenges must be addressed. Through the appropriate optimization of the preformulation, formulation and manufacturing processes of solid dosages, many limitations, such as poor drug stability, release, or bioavailability, can be overcome. Oral solid dosages include a great variety of formulations, and it is essential to establish a suitable system for each active ingredient as a function of its behavior and physicochemical properties, in order to achieve the high performance of the final product.

Prof. Dr. ‪Dumitru Lupuliasa
Dr. Anca Lucia Pop
Dr. Emma Adriana Ozon
Guest Editors

Back to TopTop