Organotypic Models and Microphysiological Systems for ADME-Related Applications
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (1 April 2023) | Viewed by 2261
Special Issue Editor
Interests: 1. Integrating in vitro systems and quantitative methods and modeling to inform drug discovery and drug product development with focus on: a. Mechanistic absorption models; b. Translational DMPK, c. Disease-based models; 2. Integrating stem cell technology, tissue biopsy, co-culture techniques, microfluidics, and next-generation sequencing to develop microphysiological systems to investigate drug- and disease-related mechanisms affecting membrane integrity and predict drug absorption/disposition: a. Development of a segment-specific intestine-on-a-chip to investigate drug- and disease-related mechanism affecting intestinal membrane integrity (leaky gut), as well as transport-mediated kinetics and drug–drug interactions; b. development of a neurovascular unit-on-a-chip model to study drug penetration in the brain parenchyma and cerebrospinal fluid, as well as molecular and cellular underlying mechanisms in neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last decade, progress has been made on the development of microphysiological systems for drug discovery and development. These models can provide new insights into the physiology and mechanisms of disease, biomarker identification and evaluation, and elucidation of the mechanisms of adverse drug reactions. Robust evidence for scalability is also emerging in the field. These models are also amenable to investigate absorption, distribution, metabolism, and excretion (ADME) properties of new drugs. Single organ or multi-organ microphysiological systems can provide critical system parameters for improved physiologically based pharmacokinetic evaluations, making this a promising tool to inform decision making at early stages of development. In the future, successful application of MPS platforms that closely mimic human physiology may ultimately reduce the need for animal models to predict ADME outcomes and decrease the overall risk and cost associated with drug development.
This Special Issue serves to highlight and capture the contemporary progress and current landscape of applying microphysiological systems to inform drug discovery and development. We invite articles on all aspects of applying microphysiological systems to predict ADME-related properties, including assessing drug–drug interactions.
Dr. Rodrigo Cristofoletti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- microphysiological systems
- organ-on-a-chip
- translational research
- organoids
- PBPK modeling
- MIDD
- ADME
