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Pharmaceutics
Special Issues
Nano-Based Drug Delivery System: Recent Developments and Future Prospects
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Nano-Based Drug Delivery System: Recent Developments and Future Prospects

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1578

Special Issue Editors

Prof. Dr. Lucas Amaral-Machado

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Guest Editor
Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; emulsified nanostructured systems; nanoparticles; drug formulation
Prof. Dr. Leonardo Miziara Barboza Ferreira

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Guest Editor
Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; bioadhesive nanostructure systems; nano-biointerface; quality control
Prof. Dr. Eryvaldo Sócrates Tabosa Do Egito

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Guest Editor
Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil
Interests: microemulsions; nanotechnology; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Jonatas Lobato Duarte

E-Mail Website
Guest Editor
Drugs and Medicines Department, Universidade Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil
Interests: nanotechnology; drug delivery; nanocarriers development

Special Issue Information

Dear Colleagues,

Nanotechnology applied to therapeutics has been widely updated, promoting adequate alternatives to improve the therapeutic arsenal in numerous disorders and diseases. Many drugs have been targeted by universities, industries and research centres in order to improve their biopharmaceutical, pharmacokinetic, physicochemical and chemical characteristics. In addition, the toxicity and side effects, as well as the low specificity of the target sites, have challenged researchers around the world to invest in nanotechnology, providing updates, including unique and numerous nanotechnology-based drug delivery systems in the world scenario. This Special Issue is dedicated to the publication of original articles and reviews focused on the development of nanostructured systems for drug delivery (synthetic, natural and mineral source); preformulation studies, evaluation of in vitro and in vivo biological activity, toxicity, genotoxicity, stability, degradation and others.

Prof. Dr. Lucas Amaral-Machado
Prof. Dr. Leonardo Miziara Barboza Ferreira
Prof. Dr. Eryvaldo Sócrates Tabosa Do Egito
Dr. Jonatas Lobato Duarte
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanostructured carriers
  • microemulsions
  • nanoemulsions
  • nanoparticles
  • liposomes
  • nanogels
  • dendrimers

Published Papers (2 papers)

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Research

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17 pages, 2196 KiB  
Article
Biological Response Following the Systemic Injection of PEG–PAMAM–Rhodamine Conjugates in Zebrafish
by Beatriz Custódio, Patrícia Carneiro, Joana Marques, Victoria Leiro, Ana M. Valentim, Mafalda Sousa, Sofia D. Santos, José Bessa and Ana P. Pêgo
Pharmaceutics 2024, 16(5), 608; https://doi.org/10.3390/pharmaceutics16050608 - 30 Apr 2024
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Abstract
Numerous therapeutic and diagnostic approaches used within a clinical setting depend on the administration of compounds via systemic delivery. Biomaterials at the nanometer scale, as dendrimers, act as delivery systems by improving cargo bioavailability, circulation time, and the targeting of specific tissues. Although [...] Read more.
Numerous therapeutic and diagnostic approaches used within a clinical setting depend on the administration of compounds via systemic delivery. Biomaterials at the nanometer scale, as dendrimers, act as delivery systems by improving cargo bioavailability, circulation time, and the targeting of specific tissues. Although evaluating the efficacy of pharmacological agents based on nanobiomaterials is crucial, conducting toxicological assessments of biomaterials is essential for advancing clinical translation. Here, a zebrafish larvae model was explored to assess the biocompatibility of poly(amido amine) (PAMAM), one of the most exploited dendrimers for drug delivery. We report the impact of a systemic injection of polyethylene glycol (PEG)-modified G4 PAMAM conjugated with rhodamine (Rho) as a mimetic drug (PEG–PAMAM–Rho) on survival, animal development, inflammation, and neurotoxicity. A concentration- and time-dependent effect was observed on mortality, developmental morphology, and innate immune system activation (macrophages). Significant effects in toxicological indicators were reported in the highest tested concentration (50 mg/mL PEG–PAMAM–Rho) as early as 48 h post-injection. Additionally, a lower concentration of PEG–PAMAM–Rho (5 mg/mL) was found to be safe and subsequently tested for neurotoxicity through behavioral assays. In accordance, no significative signs of toxicity were detected. In conclusion, the dose response of the animal was assessed, and the safe dosage for future use in theragnostics was defined. Additionally, new methodologies were established that can be adapted to further studies in toxicology using other nanosystems for systemic delivery. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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Review

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33 pages, 8768 KiB  
Review
Recent Developments in CaCO3 Nano-Drug Delivery Systems: Advancing Biomedicine in Tumor Diagnosis and Treatment
by Chenteng Lin, Muhammad Akhtar, Yingjie Li, Min Ji and Rongqin Huang
Pharmaceutics 2024, 16(2), 275; https://doi.org/10.3390/pharmaceutics16020275 - 15 Feb 2024
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Abstract
Calcium carbonate (CaCO3), a natural common inorganic material with good biocompatibility, low toxicity, pH sensitivity, and low cost, has a widespread use in the pharmaceutical and chemical industries. In recent years, an increasing number of CaCO3-based nano-drug delivery systems [...] Read more.
Calcium carbonate (CaCO3), a natural common inorganic material with good biocompatibility, low toxicity, pH sensitivity, and low cost, has a widespread use in the pharmaceutical and chemical industries. In recent years, an increasing number of CaCO3-based nano-drug delivery systems have been developed. CaCO3 as a drug carrier and the utilization of CaCO3 as an efficient Ca2+ and CO2 donor have played a critical role in tumor diagnosis and treatment and have been explored in increasing depth and breadth. Starting from the CaCO3-based nano-drug delivery system, this paper systematically reviews the preparation of CaCO3 nanoparticles and the mechanisms of CaCO3-based therapeutic effects in the internal and external tumor environments and summarizes the latest advances in the application of CaCO3-based nano-drug delivery systems in tumor therapy. In view of the good biocompatibility and in vivo therapeutic mechanisms, they are expected to become an advancing biomedicine in the field of tumor diagnosis and treatment. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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