Novel Strategies to Enhance the Encapsulation of Bioactive Molecules

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (18 March 2023) | Viewed by 2385

Special Issue Editor


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Guest Editor
College of Pharmaceutical Science, Sorocaba University, Sao Paulo, Brazil
Interests: biomaterial; nanotechnology; target delivery; drug encapsulation; agrochemical encapsulation
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Special Issue Information

Dear Colleagues,

Enhanced drug encapsulation is especially concerned with targeted delivery, modified release, and therapeutic impact; however, several factors can influence the encapsulation efficiency and hamper the success of an innovative idea and its potential for the effective treatment of diseases. Therefore, the efficient encapsulation of drugs is among the major challenges for pharmacists, chemists, biotechnologists, and other scientists involved with new technologies for the delivery systems of bioactive compounds. Many disease-related drugs and bioactive molecules have shown improved bioavailability, control delivery, and bioactivity upon successful encapsulation. Many of the newly synthesized compounds of biological interest have poor bioavailability due to hydrophobicity; chemical or enzymatic degradation; short half-life; low retention time; dissolution and permeation rates; or environmental factors such as pH, clearance, myoelectric stimulus, and anatomical as well as physiological barriers. Drug encapsulation is a biopharmaceutical strategy to improve the stability, safety, and efficacy of drugs and other bioactives, making them far superior to their conventional counterpart dosage forms.

This Special Issue aims to publish research involving novel strategies to enhance the encapsulation efficiency of bioactive molecules to improve bioavailability, overcome the anatomical and physiological barriers to targeted delivery, and promote modified drug delivery.

In this Special Issue, original research articles and reviews are welcome. All research areas that include the encapsulation of bioactive molecules are well-regarded.

I look forward to receiving your contributions.

Prof. Dr. Marco Chaud
Guest Editor

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Keywords

  • drug encapsulation
  • microparticles
  • nanoparticles
  • nanoemulsions
  • targeted delivery
  • protein encapsulation
  • colloidal systems

Published Papers (1 paper)

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Research

16 pages, 4141 KiB  
Article
Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release
by Louise Lacalendola Tundisi, Janaína Artem Ataide, Jéssica Heline Lopes da Fonseca, Luiza Aparecida Luna Silvério, Marcelo Lancellotti, Ana Cláudia Paiva-Santos, Marcos Akira d’Ávila, Daniel S. Kohane and Priscila Gava Mazzola
Pharmaceutics 2023, 15(3), 841; https://doi.org/10.3390/pharmaceutics15030841 - 4 Mar 2023
Cited by 4 | Viewed by 1932
Abstract
A poloxamer 407 (P407)—Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamer-casein hydrogel in a different addition order to evaluate the effect [...] Read more.
A poloxamer 407 (P407)—Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamer-casein hydrogel in a different addition order to evaluate the effect of gel formation. Nanoparticles were prepared by the nanoprecipitation technique and characterized by evaluating their physicochemical characteristics and morphology. The nanoparticles had a mean diameter of 196.7 ± 0.7 nm, PDI of 0.07, negative ζ potential (−0.713 mV), high encapsulation efficiency (>98%), and did not show cytotoxic effects in primary human keratinocytes. PCL-NP modulated terbinafine was released in artificial sweat. Rheological properties were analyzed by temperature sweep tests at different addition orders of nanoparticles into hydrogel formation. The rheological behavior of nanohybrid hydrogels showed the influence of TBH-PCL nanoparticles addition in the mechanical properties of the hydrogel and a long-term release of the nanoparticles from it. Full article
(This article belongs to the Special Issue Novel Strategies to Enhance the Encapsulation of Bioactive Molecules)
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