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Pharmaceutics
Special Issues
Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems
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Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 16341

Special Issue Editors

Prof. Dr. Yongmin Yan

E-Mail Website
Guest Editor
Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, China
Interests: stem cell; extracellular vesicle; drug delivery
Prof. Dr. Song Shen

E-Mail Website
Guest Editor
School of Pharmaceutical Science, Jiangsu University, 308 Xuefu Road, Zhenjiang 212013, China
Interests: iron oxide; oxidative stress; nanoparticles; drug release
Prof. Dr. Dawei Cui

E-Mail Website
Guest Editor
The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 31003, China
Interests: inflammation; extracellular vesicle; immunomodulation

Special Issue Information

Dear Colleagues,

Both oxidative stress and inflammation are critical contributors to the onset and progression of human disease by promoting cell death or by disrupting pro-survival signals. Therefore, lowering oxidative stress and inflammation could shed light on the treatment of these diseases by maintaining the balance between cell death and cell survival.

Novel drug formulation and delivery systems could provide remarkable breakthroughs in oxidative stress and inflammation prevention, diagnosis, and treatment. This Special Issue will highlight: 1) the exploration of novel molecular mechanisms and new drug therapeutic targets in oxidative stress and inflammation; 2) innovative drug formulation for the treatment of antioxidant stress and inflammation; 3) the development of approaches of formulation systems to improve the drug delivery potential, drug biodistribution, drug release, and drug targeting ability.

Prof. Dr. Yongmin Yan
Prof. Dr. Song Shen
Prof. Dr. Dawei Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • inflammation
  • antioxidant
  • nanomedicine
  • drug delivery
  • drug design
  • cell death
  • apoptosis
  • autophagy
  • extracellular vesicles
  • gene therapy
  • cell therapy
  • immunomodulation

Published Papers (5 papers)

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Research

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22 pages, 8383 KiB  
Article
Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity
by Lotfi M. Aroua, Abdulelah H. Alosaimi, Fahad M. Alminderej, Sabri Messaoudi, Hamdoon A. Mohammed, Suliman A. Almahmoud, Sridevi Chigurupati, Abuzar E. A. E. Albadri and Nejib H. Mekni
Pharmaceutics 2023, 15(2), 457; https://doi.org/10.3390/pharmaceutics15020457 - 30 Jan 2023
Cited by 10 | Viewed by 2122
Abstract
A novel series of benzimidazole ureas 3a–h were elaborated using 2-(1H-benzoimidazol-2-yl) aniline 1 and the appropriate isocyanates 2a–h. The antioxidant and possible antidiabetic activities of the target benzimidazole-ureas 3a–h were evaluated. Almost all compounds 3a–h displayed strong to moderate antioxidant [...] Read more.
A novel series of benzimidazole ureas 3a–h were elaborated using 2-(1H-benzoimidazol-2-yl) aniline 1 and the appropriate isocyanates 2a–h. The antioxidant and possible antidiabetic activities of the target benzimidazole-ureas 3a–h were evaluated. Almost all compounds 3a–h displayed strong to moderate antioxidant activities. When tested using the three antioxidant techniques, TAC, FRAP, and MCA, compounds 3b and 3c exhibited marked activity. The most active antioxidant compound in this family was compound 3g, which had excellent activity using four different methods: TAC, FRAP, DPPH-SA, and MCA. In vitro antidiabetic assays against α-amylase and α-glucosidase enzymes revealed that the majority of the compounds tested had good to moderate activity. The most favorable results were obtained with compounds 3c, 3e, and 3g, and analysis revealed that compounds 3c (IC50 = 18.65 ± 0.23 μM), 3e (IC50 = 20.7 ± 0.06 μM), and 3g (IC50 = 22.33 ± 0.12 μM) had good α-amylase inhibitory potential comparable to standard acarbose (IC50 = 14.21 ± 0.06 μM). Furthermore, the inhibitory effect of 3c (IC50 = 17.47 ± 0.03 μM), 3e (IC50 = 21.97 ± 0.19 μM), and 3g (IC50 = 23.01 ± 0.12 μM) on α-glucosidase was also comparable to acarbose (IC50 = 15.41 ± 0.32 μM). According to in silico molecular docking studies, compounds 3a–h had considerable affinity for the active sites of human lysosomal acid α-glucosidase (HLAG) and pancreatic α-amylase (HPA), indicating that the majority of the examined compounds had potential anti-hyperglycemic action. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems)
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9 pages, 1646 KiB  
Communication
Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies
by Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Flávia Amanda Pedroso de Morais, Renato Sonchini Gonçalves, Bruna Moura Rodrigues, Magali Soares dos Santos Pozza, Lidiane Vizioli de Castro-Hoshino, Silvio Mayke Leite, Otávio Augusto Capeloto, Mauro Luciano Baesso, Paulo Cesar Pozza and Wilker Caetano
Pharmaceutics 2023, 15(2), 346; https://doi.org/10.3390/pharmaceutics15020346 - 20 Jan 2023
Cited by 2 | Viewed by 1622
Abstract
Copaiba oil-resin (COR) extracted from Copaifera reticulata Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR [...] Read more.
Copaiba oil-resin (COR) extracted from Copaifera reticulata Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR was stabilized in a gel matrix constituted by carbopol C934P and Pluronic® F127 (ECO formulation) ratios. The permeation study of ECO was accessed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). The results reveal a high capacity of ECO to permeate deep skin layers. Dairy cows with a history of mastitis were used as in vivo models and exposed to ECO treatment. Monitoring of the teat’s inflammatory response showed that ECO effectively prevents mastitis. Furthermore, the ECO formulation was able to form a thin film gel on the application side, preventing fly proliferation and significantly reducing the pathogen load. This study reveals a drug that can used as an alternative application for mastitis in human or veterinary clinics. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems)
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Review

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25 pages, 1751 KiB  
Review
Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications
by Leila Pirmoradi, Shahla Shojaei, Saeid Ghavami, Atefeh Zarepour and Ali Zarrabi
Pharmaceutics 2023, 15(9), 2284; https://doi.org/10.3390/pharmaceutics15092284 - 05 Sep 2023
Cited by 1 | Viewed by 1219
Abstract
Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make [...] Read more.
Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make them a key component of medical strategies in different areas, such as osteogenesis, angiogenesis, neurodegenerative disease treatment, and cancer therapy. The application of implants and their modulatory effects on autophagy have been known in recent years. However, more studies are necessary to clarify the interactions and all the involved mechanisms. The advantages and disadvantages of nanomaterial-mediated autophagy need serious attention in both the biological and bioengineering fields. In this mini-review, the role of autophagy after biomaterial exploitation and the possible related mechanisms are explored. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems)
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21 pages, 564 KiB  
Review
The In Vitro, Ex Vivo, and In Vivo Effect of Edible Oils: A Review on Cell Interactions
by Ioannis Tsamesidis and Eleni P. Kalogianni
Pharmaceutics 2023, 15(3), 869; https://doi.org/10.3390/pharmaceutics15030869 - 08 Mar 2023
Cited by 4 | Viewed by 2131
Abstract
Consumption of edible oils is a significant part of the dietary pattern in the developed and developing world. Marine and vegetable oils are assumed to be part of a healthy food pattern, especially if one takes into account their potential role in protecting [...] Read more.
Consumption of edible oils is a significant part of the dietary pattern in the developed and developing world. Marine and vegetable oils are assumed to be part of a healthy food pattern, especially if one takes into account their potential role in protecting against inflammation, cardiovascular disease, and metabolic syndrome due to the presence of polyunsaturated fatty acids and minor bioactive compounds. Exploring the potential effect of edible fats and oils on health and chronic diseases is an emerging field worldwide. This study reviews the current knowledge of the in vitro, ex vivo, and in vivo effect of edible oils in contact with various cell types and aims to demonstrate which nutritional and bioactive components of a variety of edible oils present biocompatibility, antimicrobial properties, antitumor activity, anti-angiogenic activity, and antioxidant activity. Through this review, a wide variety of cell interactions with edible oils and their potential to counteract oxidative stress in pathological conditions are presented as well. Moreover, the gaps in current knowledge are also highlighted, and future perspectives on edible oils and their health benefits and potential to counteract a wide variety of diseases through possible molecular mechanisms are also discussed. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems)
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38 pages, 14628 KiB  
Review
Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds
by Daniela Franceschi Nishikito, Ana Claudia Abdalla Borges, Lucas Fornari Laurindo, Alda M. M. Bueno Otoboni, Rosa Direito, Ricardo de Alvares Goulart, Claudia C. T. Nicolau, Adriana M. R. Fiorini, Renata Vargas Sinatora and Sandra M. Barbalho
Pharmaceutics 2023, 15(1), 159; https://doi.org/10.3390/pharmaceutics15010159 - 03 Jan 2023
Cited by 14 | Viewed by 8002
Abstract
Dragon fruit (Hylocereus genus) has the potential for the prevention of diseases associated with inflammatory and oxidative processes. We aimed to comprehensively review dragon fruit health effects, economic importance, and possible use in delivery systems. Pubmed, Embase, and Google Scholar were searched, [...] Read more.
Dragon fruit (Hylocereus genus) has the potential for the prevention of diseases associated with inflammatory and oxidative processes. We aimed to comprehensively review dragon fruit health effects, economic importance, and possible use in delivery systems. Pubmed, Embase, and Google Scholar were searched, and PRISMA (Preferred Reporting Items for a Systematic Review and Meta-Analysis) guidelines were followed. Studies have shown that pitaya can exert several benefits in conditions such as diabetes, dyslipidemia, metabolic syndrome, cardiovascular diseases, and cancer due to the presence of bioactive compounds that may include vitamins, potassium, betacyanin, p-coumaric acid, vanillic acid, and gallic acid. Moreover, pitaya has the potential to be used in food and nutraceutical products as functional ingredients, natural colorants, ecologically correct and active packaging, edible films, preparation of photoprotective products, and additives. Besides the importance of dragon fruit as a source of bioactive compounds, the bioavailability is low. The development of delivery systems such as gold nanoparticles with these compounds can be an alternative to reach target tissues. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation: Novel Drug Formulation and Delivery Systems)
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