Formulation Strategies to Optimize Drug Pharmacokinetics and Improve Therapeutic Outcomes
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 10 June 2024 | Viewed by 1190
Special Issue Editor
Interests: pharmacokinetics; pharmacodynamics; PBPK modeling; drug–drug interactions; special populations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Safe and effective drug therapy involves delivering the correct amount of medication over an appropriate timeframe so that target plasma concentrations are achieved and/or maintained. Pharmacokinetics is a critical determinant of drug action in vivo since it drives the systemic exposure that is achieved following drug administration. Undesirable pharmacokinetic properties can compromise drug safety and efficacy in various ways. For example, a medication with a short elimination half-life may require dosing a patient multiple times each day, which can negatively impact patient adherence. Additionally, wide fluctuations in plasma levels during a dosing interval can result in adverse effects resulting from high peak concentrations or loss of activity due to low trough levels of the drug. In these situations, and others, formulation scientists can develop novel delivery systems to improve the plasma profile of a medication, thereby optimizing therapeutic outcomes.
This issue is dedicated to investigations demonstrating the application of formulation science to improve pharmacokinetic profiles by modifying drug absorption, distribution, metabolism, or excretion. Pharmaceutical scientists are invited to share their research demonstrating how pharmacokinetic properties of a drug product were optimized through formulation development to improve bioavailability, reduce food effects, mitigate drug–drug interactions, provide patient-friendly dosing schedules, increase the safety profile of medication, etc.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: the development and in vivo characterization of modified release formulations; novel delivery systems for extravascular administration, including nasal and pulmonary routes; and applications of model-informed formulation development approaches, including physiologically based biopharmaceutics modeling (PBBM).
I look forward to receiving your contributions.
Prof. Dr. David R. Taft
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- formulation development
- pharmacokinetics
- biopharmaceutics
- in vitro/in vivo extrapolation/correlation
- bioavailability
- modified release
