New Trends in Neutrophil-Based Drug Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 96
Special Issue Editor
Interests: drug delivery; cell-based therapy; intravital microscopy; inflammatory diseases and cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neutrophils—the most abundant white blood cells—perform various functions, including neutrophil extracellular trap formation, phagocytosis, and releasing proteolytic enzymes, cytokines, chemokines, and immunosuppressive molecules. Neutrophils play an important role in acute and chronic inflammation, suggesting that these cells are a key component of targeted therapies for various inflammation-related diseases. A characteristic property of neutrophils is their ability to migrate and penetrate tissues, such as inflammation loci, tumors, and the central nervous system; these include their excellent BBB/BTB-crossing capability and penetrating inflamed brain tumors. Cell-mediated drug delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. The advantages of neutrophils are their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability. There are two biomimetic drug delivery systems: neutrophils acting directly as drug carriers or neutrophil-membrane-coated nanoparticles. For this Special Issue, original research articles and reviews are welcome.
Dr. Zhenjia Wang
Guest Editor
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Keywords
- neutrophils
- targeted drug delivery
- BBB/BTB
- nanoparticles
- cancer therapy
